SAM-e is an acronym for S-adenosyl-L-methionine, a natural compound found in every human cell and involved in over 35 biochemical processes in the body. Clinical research findings, as demonstrated in this Evidence Report summary, support SAM-e???s ability to relieve depression and osteoarthritis joint pain, as well as promoting liver health. SAM-e was officially introduced into the U.S. as a dietary supplement in 1998.