Aspirin went on sale as the first pharmaceutical drug in 1899, after Felix Hoffman, a German chemist at the drug company Bayer, successfully modified Salicylic Acid, a compound found in willow bark to produce Aspirin.
Bayer® Aspirin was the first drug ever to be marketed in tablet form. First marketed in 1899 as a powder, by 1900 aspirin was being compressed into a water-soluble tablet.
Cocaine was the first local anesthetic; being used as such from about 1884 onwards.
Cocaine works in a totally different way from narcotics such as morphine or heroin. Heroin works on receptor sites in the brain which are stimulated by the drug to produce pain-relieving and mood-enhancing chemicals. Cocaine on the other hand works by stimulating the central nervous system, and like alcohol, is processed through the liver.
'Crack' is the street name given to cocaine that has been processed from cocaine hydrochloride to a free base for smoking. Rather than requiring the more volatile method of processing cocaine using ether, crack cocaine is processed with ammonia or sodium bicarbonate (baking soda) and water and heated to remove the hydrochloride, thus producing a form of cocaine that can be smoked. The term 'crack' refers to the crackling sound heard when the mixture is smoked (heated), presumably from the sodium bicarbonate. 'Crack Cocaine' is still cocaine. It is simply a different chemical process applied to cocaine powder that allows cocaine to be smokeable. This means that the 'high' from Crack Cocaine is much stronger and more immediate (taking about 8 seconds to reach the brain); and also shorter lived then from the powder.
Bayer® Aspirin was the first drug ever to be marketed in tablet form. First marketed in 1899 as a powder, by 1900 aspirin was being compressed into a water-soluble tablet.
Cocaine was the first local anesthetic; being used as such from about 1884 onwards.
Cocaine works in a totally different way from narcotics such as morphine or heroin. Heroin works on receptor sites in the brain which are stimulated by the drug to produce pain-relieving and mood-enhancing chemicals. Cocaine on the other hand works by stimulating the central nervous system, and like alcohol, is processed through the liver.
'Crack' is the street name given to cocaine that has been processed from cocaine hydrochloride to a free base for smoking. Rather than requiring the more volatile method of processing cocaine using ether, crack cocaine is processed with ammonia or sodium bicarbonate (baking soda) and water and heated to remove the hydrochloride, thus producing a form of cocaine that can be smoked. The term 'crack' refers to the crackling sound heard when the mixture is smoked (heated), presumably from the sodium bicarbonate. 'Crack Cocaine' is still cocaine. It is simply a different chemical process applied to cocaine powder that allows cocaine to be smokeable. This means that the 'high' from Crack Cocaine is much stronger and more immediate (taking about 8 seconds to reach the brain); and also shorter lived then from the powder.