Viagra, cardiac hypertrophy rat studies

[Standard Donkey]

Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-existing Advanced Hypertrophy due to Pressure-Overload


i thought this was interesting... sure it's just rats/mice/whatever..


does anyone know the effect in humans?

SIL (viagra) arrested further progressive chamber dilation, dysfunction, fibrosis, and molecular remodeling, increasing myocardial protein kinase G activity. Isolated myocytes from TAC-SIL hearts displayed greater sarcomere shortening and relaxation, and enhanced Ca[SUP]2+[/SUP] transients and decay compared to non-treated TAC hearts. SIL treatment restored gene and protein expression of sarcoplasmic reticulum Ca[SUP]2+[/SUP] uptake ATPase (SERCA2a) phospholamban (PLB), and increased PLB phosphorylation (S16) ? consistent with improved calcium handling. Both the phosphatase calcineurin (Cn) and protein kinase C-α (PKCα) can lower pPLB and depress myocyte calcium cycling. Cn expression and PKCa activation (outer membrane translocation) were enhanced by chronic TAC, and reduced by SIL treatment. PKCδ and PKCε expression also rose with TAC but were unaltered by SIL treatment.

 

[Standard Donkey]

also, we know that blood pressure is one of the primary concerns that we AAS users have for our hearts/kidneys/etc.




it's common practice to donate blood every 2 months, i have a couple questions:

1. How much should be donated?
2. is donating more often, of more benefit?



i just found out my university will give me phlebotomies, lipid tests, liver tests, etc.. for freeeeeeeeeeeee (well covered by my tuition). so i want to take as much advantage of this as i can

 

[Standard Donkey]

bump

 

[Mudge]

Blood donation is a standard amount, they don't ask if you'd like to give a gallon or anything.

 

[chocolatemalt]

Blood donation is a standard amount, they don't ask if you'd like to give a gallon or anything.

Lol... vision of a small pile of corpses outside the bloodmobile of donors that were too generous.