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What is steroid 36644-Ba ?
In 1960, the pharmaceutical company CIBA put the anabolic steroid methandrostenolone on the market as Dianabol. That became a blockbuster. With Dianabol the anabol age began in bodybuilding and weightlifting . In the years following that successful introduction, CIBA studied another anabolic steroid about which hardly anything is known. What kind of anabolic was steroid 36644-Ba ?
Steroid 36644-Ba
Fair is fair. The chemical structure of 36644-Ba looks insane. The chemical structures, we should actually say. 36644-Ba was actually a mixture of two substances that change into each other spontaneously and continuously .
The first structural formula below is the official, the second is the metabolite in which the parent compound of 36644-Ba is constantly changing - and which then changes back into the parent compound.
Biological effect
[TABLE="class: cms_table, width: 358, align: right"]
[TR]
[/TR]
[/TABLE]
The only studies on the biological activity of 36644-Ba that we have been able to obtain are complex animal studies, in which test animals not only received 36644-Ba, but also a corticosteroid. Corticosteroids break down muscle tissue.
In muscle cells, corticosteroids reduce the production of muscle proteins by the ribosomes. In a handful of studies, CIBA researchers showed that 36644-Ba can maintain protein synthesis of ribosomes during corticosteroid administration. One of those studies, which appeared in 1968, can be found in its entirety in PubMed Central. [Biochem J. 1968; 108 (3): 417-25.]
In 1970, researchers published a similar study in which 36644 Ba had a more potent effect than stanozolol. We could not find that study. What we know about it comes from the Annual Reports in Medicinal Chemistry, published by Academic Press in 1971 . [books.google.nl]
Classical animal study
In the introduction to the 1968 publication, the authors say that standard animal studies have indeed been carried out that give chemists an idea of ??the desired anabolic properties and undesirable androgenic properties of anabolic steroids.
That data comes from the Proceedings of the Second International Congress on Hormonal Steroids, Milan, May 23-28, 1966 . [annals.org] We could not get hold of that publication either.
Forgotten
The most recent scientific reference to 36644-Ba dates from 2009. In that year, the Australian doping hunter Ray Kazlauskas mentioned 36644-Ba in his chapter on designer steroids in the bundle Doping in Sports: Biochemical Principles, Effects and Analysis , published in 2009 at Academic Press. [Link]
" 36644-Ba seems to be very active, but does not seem to have been used other than as an experimental drug, " Kazlauskas writes on page 168.
Source:
Biochem J. 1968; 108 (3): 417-25.
In 1960, the pharmaceutical company CIBA put the anabolic steroid methandrostenolone on the market as Dianabol. That became a blockbuster. With Dianabol the anabol age began in bodybuilding and weightlifting . In the years following that successful introduction, CIBA studied another anabolic steroid about which hardly anything is known. What kind of anabolic was steroid 36644-Ba ?
Steroid 36644-Ba
Fair is fair. The chemical structure of 36644-Ba looks insane. The chemical structures, we should actually say. 36644-Ba was actually a mixture of two substances that change into each other spontaneously and continuously .
The first structural formula below is the official, the second is the metabolite in which the parent compound of 36644-Ba is constantly changing - and which then changes back into the parent compound.
Biological effect
[TABLE="class: cms_table, width: 358, align: right"]
[TR]
[/TR]
[/TABLE]
The only studies on the biological activity of 36644-Ba that we have been able to obtain are complex animal studies, in which test animals not only received 36644-Ba, but also a corticosteroid. Corticosteroids break down muscle tissue.
In muscle cells, corticosteroids reduce the production of muscle proteins by the ribosomes. In a handful of studies, CIBA researchers showed that 36644-Ba can maintain protein synthesis of ribosomes during corticosteroid administration. One of those studies, which appeared in 1968, can be found in its entirety in PubMed Central. [Biochem J. 1968; 108 (3): 417-25.]
In 1970, researchers published a similar study in which 36644 Ba had a more potent effect than stanozolol. We could not find that study. What we know about it comes from the Annual Reports in Medicinal Chemistry, published by Academic Press in 1971 . [books.google.nl]
Classical animal study
In the introduction to the 1968 publication, the authors say that standard animal studies have indeed been carried out that give chemists an idea of ??the desired anabolic properties and undesirable androgenic properties of anabolic steroids.
That data comes from the Proceedings of the Second International Congress on Hormonal Steroids, Milan, May 23-28, 1966 . [annals.org] We could not get hold of that publication either.
Forgotten
The most recent scientific reference to 36644-Ba dates from 2009. In that year, the Australian doping hunter Ray Kazlauskas mentioned 36644-Ba in his chapter on designer steroids in the bundle Doping in Sports: Biochemical Principles, Effects and Analysis , published in 2009 at Academic Press. [Link]
" 36644-Ba seems to be very active, but does not seem to have been used other than as an experimental drug, " Kazlauskas writes on page 168.
Source:
Biochem J. 1968; 108 (3): 417-25.
