Why antioxidants won't make DNP any less risky
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DNP, the risky illegal fat loss drug from hardcore bodybuilding, is made a little less risky by supplementing with antioxidants like vitamin C, vitamin E, NAC and glutathione. At least, that's what some doping gurus say. But is this correct? If you have read the animal study that Finnish biologists published in Comparative Biochemistry and Physiology Part C, you are inclined to answer this question with 'no'.Study
Antoine Stier from the University of Turku in Finland experimented with zebra finches. Taurus gave a group of zebra finches drinking water for 4 years, and another group of drinking water containing DNP.
The finches were given 4 milligrams of DNP per kilo of body weight per day . If the finches had been humans, they would have only received a fraction of that dose. The metabolism of zebra finches is much higher than that of humans.
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Results
DNP made the zebra finches slimmer. At the same time, the finches in the DNP group lived 21 percent shorter than the finches in the control group.
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In itself, the shorter lifespan of the zebra finches in the DNP is hardly surprising. DNP makes the cellular energy balance in the cells run wild, which would dramatically increase the production of aggressive molecules in the mitochondria.
Hence the advice in the steroid underground scene to combine DNP with antioxidants. But the concentration of the free oxygen radical hydrogen peroxide did not increase in zebra finches of the DNP group.
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Conclusion
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"Our study highlights that, even at a moderate dose [...], a chronic DNP treatment can shorten lifespan", summarize the researchers."DNP promotes proton flow not only across the mitochondrial membrane, but across the plasma membrane as well."
"This could be one key element explaining the negative impact of DNP on lifespan, but could potentially be solved using next generation uncouplers (e.g. BAM15) being specific to the mitochondrial membrane."
"Further studies investigating the molecular and physiological pathways by which DNP shortens lifespan in zebra finches would be useful to enable targeted investigations of sublethal deleterious effects in other animal models and potentially in humans."
"The present study should be a potential warning signal for current illegal DNP users, and raise questions for scientists investigating DNP use as a medicine."
Source:
Comp Biochem Physiol C Toxicol Pharmacol. 2020 Dec 3;242:108944.
[TABLE="align: right"]
[TR]
[TD]
[/TR]
[/TABLE]
DNP, the risky illegal fat loss drug from hardcore bodybuilding, is made a little less risky by supplementing with antioxidants like vitamin C, vitamin E, NAC and glutathione. At least, that's what some doping gurus say. But is this correct? If you have read the animal study that Finnish biologists published in Comparative Biochemistry and Physiology Part C, you are inclined to answer this question with 'no'.Study
Antoine Stier from the University of Turku in Finland experimented with zebra finches. Taurus gave a group of zebra finches drinking water for 4 years, and another group of drinking water containing DNP.
The finches were given 4 milligrams of DNP per kilo of body weight per day . If the finches had been humans, they would have only received a fraction of that dose. The metabolism of zebra finches is much higher than that of humans.
[FONT="]
[/FONT]
Results
DNP made the zebra finches slimmer. At the same time, the finches in the DNP group lived 21 percent shorter than the finches in the control group.
[FONT="]
[/FONT]
In itself, the shorter lifespan of the zebra finches in the DNP is hardly surprising. DNP makes the cellular energy balance in the cells run wild, which would dramatically increase the production of aggressive molecules in the mitochondria.
Hence the advice in the steroid underground scene to combine DNP with antioxidants. But the concentration of the free oxygen radical hydrogen peroxide did not increase in zebra finches of the DNP group.
[FONT="]
[/FONT]
Conclusion
[TABLE="width: 358, align: right"]
[TR]
[TD="align: right"][/TD]
[/TR]
[/TABLE]
"Our study highlights that, even at a moderate dose [...], a chronic DNP treatment can shorten lifespan", summarize the researchers."DNP promotes proton flow not only across the mitochondrial membrane, but across the plasma membrane as well."
"This could be one key element explaining the negative impact of DNP on lifespan, but could potentially be solved using next generation uncouplers (e.g. BAM15) being specific to the mitochondrial membrane."
"Further studies investigating the molecular and physiological pathways by which DNP shortens lifespan in zebra finches would be useful to enable targeted investigations of sublethal deleterious effects in other animal models and potentially in humans."
"The present study should be a potential warning signal for current illegal DNP users, and raise questions for scientists investigating DNP use as a medicine."
Source:
Comp Biochem Physiol C Toxicol Pharmacol. 2020 Dec 3;242:108944.
