An interesting collection of info I found recently from a number of sources. The last two portions of this are extremely interesting. None of this is mine, with the exception of my thoughts at the bottom. Thought someone might be interested,
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Tren Cough
If or when it hits you, it's likely to hit you during injection as you nick a vein and some tren directly hits the blood stream.
You will at first feel an overwhelming sensation overcome your body in an instant which will be followed be the extreme taste of the tren in your mouth...at this point you better back the needle out, because next the chest tightens up, you break out in an instant hot flash and slight sweat...then as quickly as all the aforementioned occur, you will begin to cough uncontrollably for the next several minutes which will seem like an eternity.
It will feel like you can't breath...you're thinking you're going to die or you're "checking out".
Every attempt to breath results in a cou***ng fit...don't panic, it will subside....
Then just as soon as it hit you, it is gone and you begin to feel like your going to live afterall.
This, in my experience, is what has occurred to me the two times I've ever experienced the dreaded "tren cough".
Just be patient when you inject, be absolutley sure to aspirate before injection, and inject very slowly. All while holding the pin as steady as possible....
I have found this method to really reduce the chances of the cough hitting me again...*knocking on wood*
Just be sure to get the pin out before it hits you....the first cough I experienced was mid-injection and I was so worried about what was all happening to me that I forgot about the pin in my ass....my wife said the syringe was uncontrollably bouncing all over the place as I went through my cou***ng fit...she thought it was funny at first until she realized something wasn't right...then she was about as worried as I was...but it passed and now when we look back on it, we get a good laugh from the experience.
It left a nice welt on my ass too from that pin bouncing all over the place....
I guess you will never know exactly how it's going to treat you until it happens to you.
This is how it happened to me...hope this helps to any of you that never experienced this before and what to expect, before you panic and think your going to die, like I did the first time it hit me.
Just try to remain calm, don't panic, and try to keep the breathing under control....it will pass, trust me.
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Now here is the real truth on the dreaded "Tren Cough" from a scientific point-of-view....all thanks to PJ:
Tren causes a spike in prostaglandin metabolism once injected. So what are prostaglandins?
Prostaglandins are synthesized from arachidonate (Lipoxygenase which catalyze the dioxygenation of polyunsaturated fatty acids) in the cell membrane by the action of phospholipase A2. Cyclooxygenase and lipoxygenase pathways compete with one another to form prostaglandins (as well as thromboxane or leukotriene-leukotriene being a bronchial stimulator),
In the cyclooxygenase pathway, the prostaglandins D, E, and F plus thromboxane and prostacyclin are made.
Thromboxanes are made in platelets and cause constriction of vascular smooth muscle and platelet aggregation.
Leukotrienes are made in leukocytes and macrophages via the lipoxygenase pathway. They are potent constrictors of the bronchial airways. They are also important in inflammation and hypersensitivity reactions as they increase vascular permeability.
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Tren cough and fat burning explained by Pheedno
Tren- Fat burning and "fina cough" both from prostaglandin metabolization
It's been widely disussed of Trens fat burning properties through rises in IGF and Prostaglandins. While IGF is a fairly well known substance in the bodybuilding world today, prostaglandins are fairly unknown in terms of formation and roles in the body.
So below, a brief dicription of prostoglandins and their role in fat burning, "fina cough", and why a person going through Tren administration can experience it's fat burning effects without the dreaded "Cough"
The term prostaglandin comes from the word-Prostate. The first prostoglandins were first dicovered in semen about the mid 1930's and it was thought that prostaglandins were made from the prostate. Since this time, it has been dicovered that most prostaglandins are not even constructed in the prostate.
Prostaglandins are made by two different pathways(Cyclooxygenase and Lipoxygenase), and considering prostaglandins are a group of about 20 lipid cells, they have contrary function; responsible for stimulating as well as alleviating inflammation(Inflammation stimulation is the rapid metabolism of them expelled through the bronchials), regulate blood flow to particular organs, control ion transport across membranes, modulate synaptic transmission, induce sleep, mediate lipid release, and regulate metabolism is various tissue.
Prostaglandins are synthesized from arachidonate(Lipoxygenase which catalyze the dioxygenation of polyunsaturated fatty acids) in the cell membrane by the action of phospholipase A2. Cyclooxygenase and lipoxygenase pathways, compete with one another to form prostaglandins(as well as thromboxane or leukotriene-leukotriene being a bronchial stimulator),
In the cyclooxygenase pathway, the prostaglandins D, E and F plus thromboxane and prostacyclin are made. Thromboxanes are made in platelets and cause constriction of vascular smooth muscle and platelet aggregation
Leukotrienes are made in leukocytes and macrophages via the lipoxygenase pathway. They are potent constrictors of the bronchial airways. They are also important in inflammation and hypersensitivity reactions as they increase vascular permeability.
Being that prostaglandins from either pathway, are still fatty acids of a group, they mediate lipid release and controll tissue metabolization, so fat burning is a luxerry of either pathway of formation. It's the pathway from which they are constructed that dictates "fina cough". As prostaglandins made from the Cyclooxygenase pathway dictate muscle constriction and platlet aggregation, and the Lipoxygenase pathway dictates bronchial constriction(the main form of expulsion)
Refs:
Cackatoo Press
Columbia Encyclopedia 6th Edition
Science Daily Magazine
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A user reply:
Now onto my take of the situation;
So this tren cough is caused by prostaglandin excretion which in turn causes bronchoconstriction and vasodilatation
So why not just inhibit PGE2 which specifically causes this by using NSAIDs which can inhibit cyclooxygenase which is the pathway of PGE2 formation
So pop an ibuprofen 30-100 mins before you inject your tren so if you get the cough it wont be as severe?
I will be testing out my theory when I test out some tren ace for the first time in a few weeks!
__________________________________________________
A user reply:
I take Ibuprofen when i get up first thing in the morning.I do my shots about an hour after giving myself so time to fully wake up.I have never had the tren cough and i have done 3 cycles using it ,my tren A done from the pellet conversion so it real.I have given my son shots out of the same bottle and he has gotten the cough once, but he quit using it because he does Ju-jitsu and it effects his breating too much. Dont know if the Ibuprofen helps but thats interesting
__________________________________________________
My thoughts...
Interestingly enough, what little research I have done on the NSAID idea seems to have some merit. No one has found a direct correlation between tren cough and prostaglandin metabolism but if you look into it, it seems to make sense. My question however would be why this effect only generally occurs with tren ace. Could the ester weight attatched to the hormone dictate how fast the prostaglandins are metabolized?
If this is the case then I would assume that the prostaglandins are produced in excess in response to the amount of tren entering the body with acetate. Because the ethanate ester allows the tren to be dispersed in the body at a slower rate there isn't an initial overcompensation from the prostaglandins. If this is the case then couldn't someone start with tren e and switch to tren a after the body has had some time to stabilize on the compound? Wouldn't this also suggest that tren cough would be likely at the start of the cycle (Of tren a) but not nearly as likely when one has been on for some time? But I don't believe the later to be the case. While I have no first hand experience, anecdotal experience gathered from this forum and others would seem to suggest that the tren cough is random. Regardless of when it is administered during the cycle, it could happen.
But going back to the NSAID idea. If one were to limit the amount of prostaglandins generated then conceivably one would limit the fat burning effect of tren (Assuming the idea that prostaglandins contribute to tren's fat burning ability is true). The half life of ibuprofen is 1-2 hours, so say one was to take one cap an hour before injecting. If tren cough is prostaglandin related then that should keep you from getting tren cough and would also only marginally effect overall prostaglandin generation. Staying on an NSAID however could negatively effect fat burning.
Anyway, thought that was interesting. I know a number of people have posted about tren cough lately and I don't recall anyone bringing this up.
__________________________________________________
Tren Cough
If or when it hits you, it's likely to hit you during injection as you nick a vein and some tren directly hits the blood stream.
You will at first feel an overwhelming sensation overcome your body in an instant which will be followed be the extreme taste of the tren in your mouth...at this point you better back the needle out, because next the chest tightens up, you break out in an instant hot flash and slight sweat...then as quickly as all the aforementioned occur, you will begin to cough uncontrollably for the next several minutes which will seem like an eternity.
It will feel like you can't breath...you're thinking you're going to die or you're "checking out".
Every attempt to breath results in a cou***ng fit...don't panic, it will subside....
Then just as soon as it hit you, it is gone and you begin to feel like your going to live afterall.
This, in my experience, is what has occurred to me the two times I've ever experienced the dreaded "tren cough".
Just be patient when you inject, be absolutley sure to aspirate before injection, and inject very slowly. All while holding the pin as steady as possible....
I have found this method to really reduce the chances of the cough hitting me again...*knocking on wood*
Just be sure to get the pin out before it hits you....the first cough I experienced was mid-injection and I was so worried about what was all happening to me that I forgot about the pin in my ass....my wife said the syringe was uncontrollably bouncing all over the place as I went through my cou***ng fit...she thought it was funny at first until she realized something wasn't right...then she was about as worried as I was...but it passed and now when we look back on it, we get a good laugh from the experience.
It left a nice welt on my ass too from that pin bouncing all over the place....
I guess you will never know exactly how it's going to treat you until it happens to you.
This is how it happened to me...hope this helps to any of you that never experienced this before and what to expect, before you panic and think your going to die, like I did the first time it hit me.
Just try to remain calm, don't panic, and try to keep the breathing under control....it will pass, trust me.
__________________________________________________
Now here is the real truth on the dreaded "Tren Cough" from a scientific point-of-view....all thanks to PJ:
Tren causes a spike in prostaglandin metabolism once injected. So what are prostaglandins?
Prostaglandins are synthesized from arachidonate (Lipoxygenase which catalyze the dioxygenation of polyunsaturated fatty acids) in the cell membrane by the action of phospholipase A2. Cyclooxygenase and lipoxygenase pathways compete with one another to form prostaglandins (as well as thromboxane or leukotriene-leukotriene being a bronchial stimulator),
In the cyclooxygenase pathway, the prostaglandins D, E, and F plus thromboxane and prostacyclin are made.
Thromboxanes are made in platelets and cause constriction of vascular smooth muscle and platelet aggregation.
Leukotrienes are made in leukocytes and macrophages via the lipoxygenase pathway. They are potent constrictors of the bronchial airways. They are also important in inflammation and hypersensitivity reactions as they increase vascular permeability.
__________________________________________________
Tren cough and fat burning explained by Pheedno
Tren- Fat burning and "fina cough" both from prostaglandin metabolization
It's been widely disussed of Trens fat burning properties through rises in IGF and Prostaglandins. While IGF is a fairly well known substance in the bodybuilding world today, prostaglandins are fairly unknown in terms of formation and roles in the body.
So below, a brief dicription of prostoglandins and their role in fat burning, "fina cough", and why a person going through Tren administration can experience it's fat burning effects without the dreaded "Cough"
The term prostaglandin comes from the word-Prostate. The first prostoglandins were first dicovered in semen about the mid 1930's and it was thought that prostaglandins were made from the prostate. Since this time, it has been dicovered that most prostaglandins are not even constructed in the prostate.
Prostaglandins are made by two different pathways(Cyclooxygenase and Lipoxygenase), and considering prostaglandins are a group of about 20 lipid cells, they have contrary function; responsible for stimulating as well as alleviating inflammation(Inflammation stimulation is the rapid metabolism of them expelled through the bronchials), regulate blood flow to particular organs, control ion transport across membranes, modulate synaptic transmission, induce sleep, mediate lipid release, and regulate metabolism is various tissue.
Prostaglandins are synthesized from arachidonate(Lipoxygenase which catalyze the dioxygenation of polyunsaturated fatty acids) in the cell membrane by the action of phospholipase A2. Cyclooxygenase and lipoxygenase pathways, compete with one another to form prostaglandins(as well as thromboxane or leukotriene-leukotriene being a bronchial stimulator),
In the cyclooxygenase pathway, the prostaglandins D, E and F plus thromboxane and prostacyclin are made. Thromboxanes are made in platelets and cause constriction of vascular smooth muscle and platelet aggregation
Leukotrienes are made in leukocytes and macrophages via the lipoxygenase pathway. They are potent constrictors of the bronchial airways. They are also important in inflammation and hypersensitivity reactions as they increase vascular permeability.
Being that prostaglandins from either pathway, are still fatty acids of a group, they mediate lipid release and controll tissue metabolization, so fat burning is a luxerry of either pathway of formation. It's the pathway from which they are constructed that dictates "fina cough". As prostaglandins made from the Cyclooxygenase pathway dictate muscle constriction and platlet aggregation, and the Lipoxygenase pathway dictates bronchial constriction(the main form of expulsion)
Refs:
Cackatoo Press
Columbia Encyclopedia 6th Edition
Science Daily Magazine
__________________________________________________
A user reply:
Now onto my take of the situation;
So this tren cough is caused by prostaglandin excretion which in turn causes bronchoconstriction and vasodilatation
So why not just inhibit PGE2 which specifically causes this by using NSAIDs which can inhibit cyclooxygenase which is the pathway of PGE2 formation
So pop an ibuprofen 30-100 mins before you inject your tren so if you get the cough it wont be as severe?
I will be testing out my theory when I test out some tren ace for the first time in a few weeks!
__________________________________________________
A user reply:
I take Ibuprofen when i get up first thing in the morning.I do my shots about an hour after giving myself so time to fully wake up.I have never had the tren cough and i have done 3 cycles using it ,my tren A done from the pellet conversion so it real.I have given my son shots out of the same bottle and he has gotten the cough once, but he quit using it because he does Ju-jitsu and it effects his breating too much. Dont know if the Ibuprofen helps but thats interesting
__________________________________________________
My thoughts...
Interestingly enough, what little research I have done on the NSAID idea seems to have some merit. No one has found a direct correlation between tren cough and prostaglandin metabolism but if you look into it, it seems to make sense. My question however would be why this effect only generally occurs with tren ace. Could the ester weight attatched to the hormone dictate how fast the prostaglandins are metabolized?
If this is the case then I would assume that the prostaglandins are produced in excess in response to the amount of tren entering the body with acetate. Because the ethanate ester allows the tren to be dispersed in the body at a slower rate there isn't an initial overcompensation from the prostaglandins. If this is the case then couldn't someone start with tren e and switch to tren a after the body has had some time to stabilize on the compound? Wouldn't this also suggest that tren cough would be likely at the start of the cycle (Of tren a) but not nearly as likely when one has been on for some time? But I don't believe the later to be the case. While I have no first hand experience, anecdotal experience gathered from this forum and others would seem to suggest that the tren cough is random. Regardless of when it is administered during the cycle, it could happen.
But going back to the NSAID idea. If one were to limit the amount of prostaglandins generated then conceivably one would limit the fat burning effect of tren (Assuming the idea that prostaglandins contribute to tren's fat burning ability is true). The half life of ibuprofen is 1-2 hours, so say one was to take one cap an hour before injecting. If tren cough is prostaglandin related then that should keep you from getting tren cough and would also only marginally effect overall prostaglandin generation. Staying on an NSAID however could negatively effect fat burning.
Anyway, thought that was interesting. I know a number of people have posted about tren cough lately and I don't recall anyone bringing this up.
