Anavar (oxandrolone) and fat burning ??? possible mechanism of action

[Arnold]

Anavar (oxandrolone) and fat burning ??? possible mechanism of action (*study)
by Anthony Roberts

For years, steroid users have classified Anavar as a fat-burning drug. The research certainly bears this out, as numerous studies have shown that men given the drug typically lose fat mass while increasing strength and lean body mass. And now a recent study has put forth a potential mechanism of action for these effects, postulating that Anavar may act directly in the liver to stimulate fatty acid oxidation. Anavar is one of the ???good-guy??? steroids that can be used for a variety of conditions that range from increasing short stature in children and girls with Turners Syndrome to accelerating the healing of burn victims. It???s also been used to prevent muscle wasting in AIDS and cancer patients.

Whatever the cause, the data is very convincing and the anecdotal evidence provides good evidence that this drug has a variety of positive effects, and only one real drawback ??? the cost. In terms of FDA approved anabolic steroids, this stuff is by far the most expensive ( a trend that unfortunately holds true on the underground market as well).

Oxandrolone enhances hepatic ketogenesis in adult men.
Vega GL, Clarenbach JJ, Dunn F, Grundy SM.
Source

Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Gloria.Vega@utsouthwestern.edu

Abstract
BACKGROUND:

Immediate administration of oxandrolone markedly increases hepatic lipase activity and reduces levels of plasma high-density lipoprotein.

Photo courtesy of World-Pharma.org

RATIONALE FOR THE STUDY:

We postulated that oxandrolone should increase hepatic lipase and that the nonesterified fatty acids generated would enhance hepatic ketogenesis during an extended fat tolerance test.
MAIN RESULTS:

Eighteen men participated in the study using short-term administration of oxandrolone (10 mg/d) over a week. Subjects had evaluation of hepatic ketogenesis at baseline and after 7 days of administration of oxandrolone. Ketogenesis was assessed by measuring plasma levels of 3-hydroxybutyrate during a fat tolerance test. Oxandrolone increased fasting levels of 3-hydroxybutyrate by 70%, and increased the area under the curve during an FFT by 53% above pretreatment levels without affecting the areas under the curve for nonesterified fatty acids, glycerol, or triglycerides. Fasting 3-hydroxybutyrate levels correlated with nonesterified fatty acids and with triglycerides; however, there were no significant correlations with any other parameter.

CONCLUSIONS:

This study shows that short-term administration of oxandrolone results in marked increases in hepatic ketogenesis. This finding is consistent with an increased influx of fatty acids into the liver secondary to lipoprotein lipolysis by increased hepatic lipase. However, the possibility cannot be ruled out that oxandrolone acts directly in the liver to stimulate fatty acid oxidation. Therefore, the observation of increased ketogenesis will require further studies to determine the molecular basis of the response.

source

 

[heavyiron]

Thats a decent response for such a low dose af anavar. I would love to see data on 25mg daily.

 

[withoutrulers]

Do you suppose anavar is so expensive due to cost of production or low demand?