Triazole??? also introduces CAPE, an all-natural SERM (selective estrogen receptor modulator) found in bee propolis extract. Propolis is a resin that bees use for structural support of their hive, but recent research has shown it to have numerous health benefits. These include reducing inflammation, strengthening the immune system and being excellent for heart health. While propolis contains many constituents, it is only CAPE that was demonstrated to displace estrogen from the estrogen receptor. If CAPE is occupying the estrogen receptor, then the estrogen hormone has no way to bind to it itself making CAPE a novel SERM! In addition, CAPE has been shown to downregulate estrogen receptor expression, or in other words, reduce the amount of estrogen receptors.
One other exciting property of CAPE that has been shown recently in research is its effect inhibiting a highly pro-inflammatory signalling molecule called NF-kB. Scientists are investigating compounds that can achieve this because inhibition of NF-kB signalling has potential therapeutic application in cancer and other inflammatory diseases.
Jung BI, Kim MS, Kim HA, Kim D, Yang J, Her S, Song YS. Caffeic acid phenethyl ester, a component of beehive propolis, is a novel selective estrogen receptor modulator. Phytother Res. 2010 Feb;24(2):295-300.
Curcumin is the main compound found in the Curcuma longa plant. It is no secret in traditional Indian Ayurvedic medicine where it has been a staple for over three thousand years. Clinical research has finally caught up to it and studies showing the benefits of curcumin have been released at an alarming rate in the past decade. Its benefits include anti-oxidant capacity, anti-inflammatory properties, anti-depressant effects, and even anti-cancer/anti-tumor properties. The latter is interesting because it appears to work by inhibiting NF-kB, much like CAPE. While there is no scientific study investigating this, there are a lot of anecdotal reports suggesting that curcumin can work to reduce gyno. If you want to see these reports, simply type ???curcumin + gyno??? into any popular online search engine and you???ll be met with more than you???ll have time to read!
Curcumin also works SYNERGISTICALLY with CAPE to help reduce oxidative stress ??? something that can lead to cell damage and negatively impact your ability to recover. They do this by inducing a protein called Heme Oxygenase-1 (HO-1). Prunella Vulgaris also induces this protein, giving you a trilogy of anti-oxidant effects!
Triazole??? also comes with added Bioperine®, a standardized extract from the fruit of Piper nigrum L (black pepper). Bioperine® is clinically proven to enhance the oral bioavailability of other co-ingested compounds. This significantly increases the effectiveness of the Triazole??? formula. In fact, Bioperine® increases the effectiveness of curcumin alone by 2000%!
Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008 Oct 8;269(2):199-225.
Bachmeier BE, Mohrenz IV, Mirisola V, Schleicher E, Romeo F, Höhneke C, Jochum M, Nerlich AG, Pfeffer U. Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis. 2008 Apr;29(4):779-89.
Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.
Although today's compounds (the last 2 of the formula) arent new we think they fit perfectly with the overall use and design of the formula. The last 2 are Maca and Zinc Aspartate. With the Maca we are using a strong dose of a 20:1 extract. As far as I know no one else is using such a high potency extract. Its not only GREAT for sex drive but it also increases endurance. Here's a study done with maca and cyclists. The results are very positive.
J Ethnopharmacol. 2009 Dec 10;126(3):574-6. Epub 2009 Sep 23.
A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen.
AIMS OF THE STUDY: Maca (Lepidium meyenii Walp) is consumed both as a sports supplement by strength and endurance athletes, and as a natural stimulant to enhance sexual drive. However, whether or not the postulated benefits of maca consumption are of scientific merit is not yet known. The aim of the study was therefore to investigate the effect of 14 days maca supplementation on endurance performance and sexual desire in trained male cyclists. MATERIALS AND METHODS: Eight participants each completed a 40 km cycling time trial before and after 14 days supplementation with both maca extract (ME) and placebo, in a randomised cross-over design. Subjects also completed a sexual desire inventory during each visit. RESULTS: ME administration significantly improved 40 km cycling time performance compared to the baseline test (P=0.01), but not compared to the placebo trial after supplementation (P>0.05). ME administration significantly improved the self-rated sexual desire score compared to the baseline test (P=0.01), and compared to the placebo trial after supplementation (P=0.03). CONCLUSIONS: 14 days ME supplementation improved 40 km cycling time trial performance and sexual desire in trained male cyclists. These promising results encourage long-term clinical studies involving more volunteers, to further evaluate the efficacy of ME in athletes and normal individuals and also to explore its possible mechanisms of action.
PMID: 19781622
Zinc aspartate, what more needs to be said about it.
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