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This compound is revolutionizing our research. The moniker ?Exercise in a Bottle? suits this research compound perfectly. Just to clarify this often mislabeled or misunderstood compound. It is not a peptide, nor is it a SARM, it is a liquid research chemical.
Upon administration of Liquid GW1516 to our research subjects multiple effects take place. First off it acts as a peroxisome proliferator activated receptor modulator (PPARM). PPARM?s are proteins which are responsible for triggering specific genetic transcriptions. The genes affected are largely expressed in adipose tissue (body fat). The result of this expression plays heavily in what the body metabolizes for fuel. ie: Carbohydrates, body fat, proteins. The main effect is this genetic expression shift the metabolism of body fat as the primary source of fuel or energy.
Secondly it activates AMP-activated protein kinase. AMPk is an enzyme that plays a key role in cellular energy expenditure. It is expressed greatly in skeletal muscle. It regulates fatty acid metabolism, inhibits cholesterol uptake, and promotes glucose uptake to muscle cells. It also plays a role in the regulation of the secretion of insulin.
So let?s look at the cumulative effects of these 2 primary pathways of action. The research subject shifts its primary source of energy from carbohydrates to body fat. The cellular energy expenditure increases (increase in basal metabolic rate). The metabolism of fatty acids increases and the lipid profile (cholesterol) improves. Glucose is shuttled to the muscles promoting muscle growth. Insulin, the most anabolic of all hormones, is released.
Very quickly one can see the amazing impact Liquid GW1516 would have on a research subject. The loss of body fat, increase in muscle tissue, improved cholesterol profile, and dramatic change in body composition really does justify it being called exercise in a bottle.
This astounding compound may very well revolutionize the way we do our research, as well as the results of said research. This is not one researchers want to miss out on!
Check it out >> Liquid GW1516 30mL 5mg/mL or Liquid GW1516 60mL 5mg/mL
Refs:
*Berger J, Moller DE (2002). "The mechanisms of action of PPARs". Annu. Rev. Med. 53: 409?35. doi:10.1146/annurev.med.53.082901.104018. PMID 11818483
*Issemann I, Green S (1990). "Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators". Nature 347 (6294): 645?50. doi:10.1038/347645a0. 2129546
*Narkar VA, Downes M, Yu RT, Embler E, Wang Y-X, Banayo E, Mihaylova MM, Nelson MC, Zou Y, H, Kang H, Shaw RJ,2 Evans RM (August 2008). "AMPK and PPARδ Agonists Are Exercise Mimetics" Cell 134 (3): 1?11. doi:10.1016/j.cell.2008.06.051. PMC 2706130. PMID 1867480
*Barish GD, Narkar VA, Evans RM (March 2006). "PPAR delta: a dagger in the heart of the metabolic syndrome". J. Clin. Invest. 116 (3): 590?7. doi:10.1172/JCI27955. PMC 1386117. PMID 16511591
*Uwe Dressel, Tamara L. Allen, Jyotsna B. Pippal, Paul R. Rohde, Patrick Lau, and George E. O. Musc (2003)"The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells". Molecular Endocrinology (17): 2477?93. doi:10.1210/me.2003-015. PMID 14525954
Liquid GW1516 30mL 5mg/mL or Liquid GW1516 60mL 5mg/mL
Upon administration of Liquid GW1516 to our research subjects multiple effects take place. First off it acts as a peroxisome proliferator activated receptor modulator (PPARM). PPARM?s are proteins which are responsible for triggering specific genetic transcriptions. The genes affected are largely expressed in adipose tissue (body fat). The result of this expression plays heavily in what the body metabolizes for fuel. ie: Carbohydrates, body fat, proteins. The main effect is this genetic expression shift the metabolism of body fat as the primary source of fuel or energy.
Secondly it activates AMP-activated protein kinase. AMPk is an enzyme that plays a key role in cellular energy expenditure. It is expressed greatly in skeletal muscle. It regulates fatty acid metabolism, inhibits cholesterol uptake, and promotes glucose uptake to muscle cells. It also plays a role in the regulation of the secretion of insulin.
So let?s look at the cumulative effects of these 2 primary pathways of action. The research subject shifts its primary source of energy from carbohydrates to body fat. The cellular energy expenditure increases (increase in basal metabolic rate). The metabolism of fatty acids increases and the lipid profile (cholesterol) improves. Glucose is shuttled to the muscles promoting muscle growth. Insulin, the most anabolic of all hormones, is released.
Very quickly one can see the amazing impact Liquid GW1516 would have on a research subject. The loss of body fat, increase in muscle tissue, improved cholesterol profile, and dramatic change in body composition really does justify it being called exercise in a bottle.
This astounding compound may very well revolutionize the way we do our research, as well as the results of said research. This is not one researchers want to miss out on!
Check it out >> Liquid GW1516 30mL 5mg/mL or Liquid GW1516 60mL 5mg/mL
Refs:
*Berger J, Moller DE (2002). "The mechanisms of action of PPARs". Annu. Rev. Med. 53: 409?35. doi:10.1146/annurev.med.53.082901.104018. PMID 11818483
*Issemann I, Green S (1990). "Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators". Nature 347 (6294): 645?50. doi:10.1038/347645a0. 2129546
*Narkar VA, Downes M, Yu RT, Embler E, Wang Y-X, Banayo E, Mihaylova MM, Nelson MC, Zou Y, H, Kang H, Shaw RJ,2 Evans RM (August 2008). "AMPK and PPARδ Agonists Are Exercise Mimetics" Cell 134 (3): 1?11. doi:10.1016/j.cell.2008.06.051. PMC 2706130. PMID 1867480
*Barish GD, Narkar VA, Evans RM (March 2006). "PPAR delta: a dagger in the heart of the metabolic syndrome". J. Clin. Invest. 116 (3): 590?7. doi:10.1172/JCI27955. PMC 1386117. PMID 16511591
*Uwe Dressel, Tamara L. Allen, Jyotsna B. Pippal, Paul R. Rohde, Patrick Lau, and George E. O. Musc (2003)"The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells". Molecular Endocrinology (17): 2477?93. doi:10.1210/me.2003-015. PMID 14525954
Liquid GW1516 30mL 5mg/mL or Liquid GW1516 60mL 5mg/mL
