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Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone Analog
Because the quantity of GH release induced by GHRH will be limited by the ambient IGF-I levels, which exert a negative feedback effect, the risk of side effects associated with excessive GH secretion may be lower than with GH therapy. In addition, treatment with GHRH should result in the secretion of the whole family of GH peptides normally secreted by the pituitary, not just the 22-kDa form provided by recombinant human GH, which may have yet unrecognized beneficial effects.
Because the quantity of GH release induced by GHRH will be limited by the ambient IGF-I levels, which exert a negative feedback effect, the risk of side effects associated with excessive GH secretion may be lower than with GH therapy. In addition, treatment with GHRH should result in the secretion of the whole family of GH peptides normally secreted by the pituitary, not just the 22-kDa form provided by recombinant human GH, which may have yet unrecognized beneficial effects.