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More research on Toco-8

Here's some more good news on Toco-8:

Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases.

Abstract:
Initially discovered in 1938 as a "fertility factor," vitamin E now refers to eight different isoforms that belong to two categories, four saturated analogues (α, β, γ, and δ) called tocopherols and four unsaturated analogues referred to as tocotrienols. While the tocopherols have been investigated extensively, little is known about the tocotrienols. Very limited studies suggest that both the molecular and therapeutic targets of the tocotrienols are distinct from those of the tocopherols. For instance, suppression of inflammatory transcription factor NF-κB, which is closely linked to tumorigenesis and inhibition of HMG-CoA reductase, mammalian DNA polymerases and certain protein tyrosine kinases, is unique to the tocotrienols. This review examines in detail the molecular targets of the tocotrienols and their roles in cancer, bone resorption, diabetes, and cardiovascular and neurological diseases at both preclinical and clinical levels. As disappointment with the therapeutic value of the tocopherols grows, the potential of these novel vitamin E analogues awaits further investigation.

PMID: 20696139
 
My toco is easy to mix. First time using it and first week just threw it in with a cup of oj in the morning.
 
The emerging evidence on tocotrienols is impressive.
 
Taste isn't all that bad, I just like it mix with OJ or juice. I like the profile it brings, and anything to help your body better itself I'm game. Again another PP product that deserves respect!!
 
My toco is easy to mix. First time using it and first week just threw it in with a cup of oj in the morning.

you guys mix it? I dump it in my mouth and a lil water and its pretty decent tasting IMO
 
mmm tacos.... with salsa mmmmmm...
 
I add it to my Greek yogurt just for convenience. It doesn't add or subtract from the flavor.
 
Ill have to give this a try as well. So far though ive been good with 4% cottage cheese and adding certain things. You think Greek Yogurt would be better?

It's better for you. Probiotics and much less salt.
 
I think my wife is a placebo.
If not for my imagination i wouldn't get anything. :jerkit:
 
Tocotrienols: constitutional effects in aging and disease


Abstract
Tocotrienols, a class of vitamin E analogs, modulate several mechanisms associated with the aging process and aging-related diseases. Most studies compare the activities of tocotrienols with those of tocopherols ("classical vitamin E"). However, some biological effects were found to be unique for tocotrienols. Although the absorption mechanisms are essentially the same for all vitamin E analogs, tocotrienols are degraded to a greater extent than tocopherols. The levels of tocotrienols in the plasma of animals and humans were estimated to reach low micromolar concentrations. One hallmark in the origin of disease and aging is the overproduction of reactive oxygen species (ROS). Tocotrienols possess excellent antioxidant activity in vitro and have been suggested to suppress ROS production more efficiently than tocopherols. In addition, tocotrienols show promising nonantioxidant activities in various in vitro and in vivo models. Most notable are the interactions of tocotrienols with the mevalonate pathway leading to the lowering of cholesterol levels, the prevention of cell adhesion to endothelial cells, and the suppression of tumor cell growth. Furthermore, glutamate-induced neurotoxicity is suppressed in the presence of tocotrienols. This review summarizes the main antioxidant and nonantioxidant effects of tocotrienols and assesses their potential as health-maintaining compounds.

PMID: 15671205
 
Tocotrienols: constitutional effects in aging and disease


Abstract
Tocotrienols, a class of vitamin E analogs, modulate several mechanisms associated with the aging process and aging-related diseases. Most studies compare the activities of tocotrienols with those of tocopherols ("classical vitamin E"). However, some biological effects were found to be unique for tocotrienols. Although the absorption mechanisms are essentially the same for all vitamin E analogs, tocotrienols are degraded to a greater extent than tocopherols. The levels of tocotrienols in the plasma of animals and humans were estimated to reach low micromolar concentrations. One hallmark in the origin of disease and aging is the overproduction of reactive oxygen species (ROS). Tocotrienols possess excellent antioxidant activity in vitro and have been suggested to suppress ROS production more efficiently than tocopherols. In addition, tocotrienols show promising nonantioxidant activities in various in vitro and in vivo models. Most notable are the interactions of tocotrienols with the mevalonate pathway leading to the lowering of cholesterol levels, the prevention of cell adhesion to endothelial cells, and the suppression of tumor cell growth. Furthermore, glutamate-induced neurotoxicity is suppressed in the presence of tocotrienols. This review summarizes the main antioxidant and nonantioxidant effects of tocotrienols and assesses their potential as health-maintaining compounds.

PMID: 15671205

Seriously, I love this stuff.
 
I used up my last dose a couple of days ago. I horribly miscalculated how much I had left and am now out.

I did that with MAP, still haven't gotten a new order in yet, I really need to get on that, especially with it possibly being phased out shortly.
 
I did that with MAP, still haven't gotten a new order in yet, I really need to get on that, especially with it possibly being phased out shortly.

My MAP order is queued along with my Toco-8. Hopefully, it ships out next week.
 
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