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Originally posted by MonStar
Is this an extremely bad idea?
Originally posted by Twin Peak
Indeed.
Might as well down it with 5-6 shots of tequila while you are at it.
Originally posted by Twin Peak
Liver? What liver?
Originally posted by Twin Peak
Indeed.
Might as well down it with 5-6 shots of tequila while you are at it.
Originally posted by PreMier
This is ironic.
Originally posted by brodus
GP, do you know anyone who had bad side effects, i.e. the ubiquitous rash, and had to quit taking it?
Do you recommend to people?
Originally posted by topolo
gp can you advise on what dosage you took and for how long?
tp, can you as well please?
Originally posted by Mudge
You aren't fat so I dont know why you would even consider it, but as far as safety its about "as safe" as DNP.
Originally posted by Monolith
Isnt UA more toxic to the liver than DNP?
The study cited looks at the concentrations of UA or DNP at the target site (liver mitochondria) which cause complete shutdown of OP. In the study cited, UA did so at 1/50th the concentration of DNP. 1: Nat Toxins 1996;4(2):96-102 Related Articles, Links
Lichen acids as uncouplers of oxidative phosphorylation of mouse-liver mitochondria.
Abo-Khatwa AN, al-Robai AA, al-Jawhari DA.
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
I was the person to report extremely high liver enzyme levels. I took SU for about a week. I had some reaction so I went to the er and they did blood tests. At this point the liver enzymes were slightly high. I stopped the SU. However the enzymes continued to rise for 2 more weeks. At which point it started a downward trend and finally back to normal after a few more weeks. The doctor said there problably isn't any long term damage.
Complete shutdown of oxidative phosphoralation causes liver failure, the inhibition even seen with lower doses causes tremendous amounts of free radical damage as well as impairing liver function which in those susceptible MAY lead to early/rapid expression of liver related cancers.
1. Rash ? Some users develop a rash on usnic acid and sodium usniate. This appears to an allergic reaction to some substance within usnic acid. What we have witnessed is that the rash is mostly present in higher dosages ? usually above 750mg. In addition, the rash has subsided in all people who have reported the rash. For some it took a few days, others around 2 weeks to completely subside.
2. Heat and increased sweating ? this is the most commonly reported side effect of usnic acid. The heat stops as usage stops and is simply a by-product of the way usnic acid works in your body.
3. Headaches ? some people have reported headaches. This could very well be a result of the increased heat and potentially dehydration from increased sweating.
4. Vomiting ? 2 or 3 people reported vomiting while taking usnic acid. This tends to be a rare occurrence as far as we know.
5. Elevated enzyme levels ? A couple people checked their liver enzyme levels via a blood test and found their levels to be above normal (in one situation, quite high actually). While only a few people have checked their levels, it seems that usnic acid might indeed cause some strain on the liver. Just as 17aa orals are liver toxic and other supplements can raise blood pressure, cause prostate hypertrophy, and other sides, this might be one side effect of usnic acid use. I should point out that it is recommended that usnic acid be cycled (2 weeks at time) to give your liver sufficient recuperation time if it is indeed being strained.
6. Abdominal pain ? I have only witnessed this from a few users. This tends to be rare as well.
1)
supplements containing usnic acid (or its sodium salt) have been implicated in fulminant hepatic failure (liver problems) in close to a dozen otherwise healthy people between the ages of 18 and 32.
2)
It is my belief that the misuse of this supplement will dramatically and irrevocably increase the risk of cancer, promote serious anomalies of the body's cellular reproductive mechanisms, and potentially lead to the death of the user (not much different from DNP)
For the record, there are currently 28 patents on file with the US Patent Office concerning usnic acid, including its use as a fungicide, antibiotic, antineoplastic, antituberculotic, and for the treatment of leishmaniasis and coccicoides (parasitic infestation of the intestines).
3)
A lot of studies that deal w/ usnic acid use mice (although we can extrapolate the data to men, as mice and men are both mammalian systems), usnic acid has been shown to increase clastogenic (chromosome or gene breaking) action in mouse femur (bone) cells, something that I know we all want to avoid unless we're looking forward to osteoporosis, bone cancers, and hip replacement surgery in the near future.
here's a ref:
6) J Ethnopharmacol 1991 Jul;33(3):217-20
Thanks to T-mag I did not have to repeat myself, after saying this a million times to people.
Conclusion, if you are willing to risk osteoporosis, bone cancers, or any other tumor possibilities then go ahead and use the product....I don't condone it, neither do I think it's a positive. I'm neutral, just read the above facts and make your own decision.
FDA Warns Consumers Not to Use the Dietary Supplement Lipokinetix
The Food and Drug Administration (FDA) is warning consumers immediately to stop use of the product Lipokinetix®, marketed as a dietary supplement by Syntrax Innovations, Inc. Lipokinetix has been implicated in a number of serious liver injuries. FDA has received multiple reports of persons who developed liver injury or liver failure while using Lipokinetix.
Lipokinetix is marketed for weight loss. It contains the ingredients norephedrine (also known as phenylpropanolamine or PPA), caffeine, yohimbine, diiodothyronine, and sodium usniate. The injuries reported to FDA occurred in persons between 20 and 32 years of age. No apparent cause of liver injury was identified in these reports other than use of Lipokinetix. Liver injury developed between 2 weeks and 3 months of Lipokinetix use.