By the end of the first day I feel the mental effects of well being, calmness and superiority. Then after a week to 10 days, I notice the pump at the gym a lot more and muscles getting larger. By the end of week 3 I can definitely notice a difference. By week 4-7 I feel I peek and start to come off my cycle as I feel the internal cell regulators start to upregulate and bring the body back to homeostatis as far as protein synthesis etc. Cells that grow indefinitely would be a cancer risk so there are feedback loops within the cell to control this(ie TSC1/2 to mTOR, rapamycin, TGF-beta like myostatin, PTEN, 4ebp1...). Also, I feel as though glycogen loading/cycling helps around week 4 as insulin resistance can start to occur from constant eating. So I do a intermittent fast or two around that time to improve insulin response. Though androgens primary action is to proliferate satellite (stem) cells, and I think that effect does not degrade with time or at least in the 3 month avg cycle (I think I saw a study that showed androgen receptor downregulate after 6 months or something like that).