You DEFINITELY need a day off in a week from GH. You do NOT want to make the pituitary lazy to produce its own. On days off you can take an Arginine supplement to induce your own HGH. The human body is absolutely amazing, but you NEVER want to do a regimen for a long time that the body recognizes as a fit pattern. Everyone has heard of the phrase "shock the body." No different here. If you are planning to take GH for a very long time, SHOCK the body, and force your own pituitary to produce HGH, and then BAM you inject your synthetics and WOW! Guys all of this is pure 100% science, and applying LOGICAL theories. It is such a massive advantage to be educated in the world of science and why something does what it does. But, at the same time with HGH you want to be consistent and at least get it in you 5 times per week, but every few months I'll bluntly stop for 3-4 days, and then I introduce a VERY small amount which the body will recognize now it is NOT ENOUGH!