Q & A with John Connor Expert AAS advisor

[heavyiron]

Thank you Heavy! This thread is epic!

What is your opinion about ghrp-6? What are the side effects? Can it be used in place of hgh?

GH-releasing peptide (GHRP-6; His-D Trp-Ala-Trp-D Phe-Lys-NH2) is a synthetic compound that releases GH in a specific and dose-related manner through mechanisms and a point of action that are mostly unknown but different from those of GHRH. In man, GHRP-6 is more efficacious than GHRH, and a striking synergistic action on GH release is observed when GHRP-6 and GHRH are administered simultaneously. Based on such a synergistic action, it has been hypothesized that GHRP-6 acts through a double mechanism by actions exerted both at the pituitary and hypothalamic levels.

1. V Popovic,
2. S Damjanovic,
3. D Micic,
4. M Djurovic,
5. C Dieguez and
6. F F Casanueva

Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in man.

1. A Peñalva,
2. A Carballo,
3. M Pombo,
4. F F Casanueva and
5. C Dieguez

- Author Affiliations

1. Department of Medicine, Faculty of Medicine, University of Santiago, Santiago de Compostela, Spain.

Abstract

His-DTrp-Ala-Trp-DPhe-Lys-NH2 (GHRP-6) is a synthetic compound that releases GH in a dose-related and specific manner in several species, including man. To further characterize the effects and mechanism of action of GHRP-6 on GH secretion, we assessed in normal man plasma GH responses to that hexapeptide 1) alone and in combination with exogenous GH-releasing hormone (GHRH) administration, 2) in a state of high endogenous somatostatinergic tone after atropine administration, and 3) in a state of low endogenous somatostatinergic tone induced by the cholinergic receptor agonist drug pyridostigmine or after insulin-induced hypoglycemia. We found a similar increase in plasma GH levels after the administration of either GHRP-6 (1 microgram/kg) or GHRH (1 microgram/kg); the areas under the curve (AUC) were (mean +/- SEM) 973 +/- 181 and 821 +/- 139, respectively. After combined GHRP-6 and GHRH administration, GH responses were considerably greater than those after either compound alone (4412 +/- 842; P < 0.01). Administration of the cholinergic receptor antagonist atropine (1 mg, im) completely prevented the GH responses to GHRP-6 (area under the curve, 103 +/- 14 vs. 815 +/- 156, respectively). On the other hand, pyridostigmine, a cholinergic agonist, slightly increased GH responses to GHRP-6 (P < 0.01 when comparing the AUC after pyridostigmine administration of 1571 +/- 151 and the AUC after administration of GHRP-6 alone of 815 +/- 156). Finally, combined GHRP-6 and insulin administration induced a much greater increase in plasma GH levels (AUC, 4047 +/- 327) than insulin alone (1747 +/- 229; P < 0.05) or GHRP-6 alone (1248 +/- 376; P < 0.05). Our results lend support to the view that GHRP-6-induced GH secretion is exerted through a non-GHRH-dependent mechanism. Furthermore, the fact that enhancement of somatostatinergic tone with atropine completely prevented the GH responses to GHRP-6, while pyridostigmine and insulin-induced hypoglycemia, which increased plasma GH levels by inhibiting hypothalamic somatostatin release, increased the same response suggest that although GHRP-6-induced GH secretion is dependent on the endogenous somatostatinergic tone, the stimulatory effect of GHRP-6 on plasma GH levels is not mediated by a change in hypothalamic somatostatinergic tone.

 

[heavyiron]

thoughts on dbol at 30mgs a day for 10 weeks?

I would probably shorten the run to 8 weeks but other than that I like d-bol very much for an oral only cycle. D-bol is commonly reported to provide a sense of well being and is well known for steady strength and LBM gains.

 

[heavyiron]

Yes i plain to have my labs drawn in about a week, i believe my test is pretty low, i was blasting and cruising for 1.5 years and decided i should cycle as im still young. I believe recovery is possible for me but will be tough. Surprisingly im on day 10 and still feel good, did a shot of 100mg prop 11 days ago, and all long esters have been stopped for a couple months so i am nerviously awaiting the crash lol. My estro was high last test so i decided to go off run good pct and let body chill. Im going to look into sodium and water manipulation for sure. Im only running 100 g carbs a day and low sodium and lots cardio so i believe its estro related. Thanks for the help! Will post labs when received.

How are you feeling now brother?

 

[heavyiron]

Heavy, what is better for hard, dry and vascular look on low bf - EQ or Mast? (along with Test E).

What dosage do you recommend for that purpose?

I have a preference for Masteron myself. If diet and training are dialed in a dose of 350-500mg weekly on Mast is very nice. You could run the Testosterone anywhere from a replacement dose on up.

 

[sofargone561]

I would probably shorten the run to 8 weeks but other than that I like d-bol very much for an oral only cycle. D-bol is commonly reported to provide a sense of well being and is well known for steady strength and LBM gains.

im sorry i hsould have been more specific it would be ran with test as well

 

[heavyiron]

im sorry i hsould have been more specific it would be ran with test as well

Even better =)

 

[Rednack]

heavy, i worked my legs doing squats on friday 3/9/12....3 sets of 10 for the first time in 25 years...My legs are still sore today...I was wondering how long i need to let them recover before i work them again and are there any other exercise at the gym i could do to ease the pain?

 

[sofargone561]

Even better =)

thanks!

 

[littlekev]

How are you feeling now brother?

like shit lol heres my estro results

Component Your Value Standard Range Units
Estrone, LC/MS/MS 77
Reference range: < OR = 68
Unit: pg/mL
Estradiol, LC/MS/MS 46
Reference range: < OR = 29
Unit: pg/mL
Estriol, LC/MS/MS <0.10
Unit: ng/mL
(Note)
Ref. range: ADULTS: < OR = 0.18

This is on letro at 2.5 mgs ed so I am bummed, i thought the letro i had was g2g, Trying to get estro under conrol, had the post cycle crash going on tuesday to get estro and test levels agian. Water weight at waste still their doing everything i can.... Am on formeron now getting bloods drawn tuesday. On 4 pumps ed formeron and 40 mg nolva and natty test booster.

 

[heavyiron]

heavy, i worked my legs doing squats on friday 3/9/12....3 sets of 10 for the first time in 25 years...My legs are still sore today...I was wondering how long i need to let them recover before i work them again and are there any other exercise at the gym i could do to ease the pain?

I would wait until the soreness is gone before training them again. Pain 48 hours after a strenuous training session is normal brother. You may try a bit of cardio and see if that loosens them up a bit.

 

[nick52]

john me and my wife have a question, we are both 52 active, execise and live healthy, i have liver issues not serious at this time, im also running test at 750mgs a week our question concerns hgh releasers, a natural hgh stimulator, a couple im looking at are gen force, and secratropin hgh can these products cause the pituitary gland to release and raise hgh levels in a way that would be seen in its results (scam or legit) i know this may not be youre expertiese but these products are expensive and would like a heads up from a reliable source who i consider you to be

 

[Night_Wolf]

I have a preference for Masteron myself. If diet and training are dialed in a dose of 350-500mg weekly on Mast is very nice. You could run the Testosterone anywhere from a replacement dose on up.

Ok, tnx Heavy!

If I'm preping for a specific date and have access to only Mast Enanthate, how many weeks before that should I start using it to see the full effect?

 

[indrox1]

Hey Heavy, man you def have some great info and I sure do appreciate you sharing it with everyone. I am soaking up the knowledge bro... Awesome! Have question for you... I was on a bulk cycle (from Sept to Dec 2011, 16 weeks) using 900 mg of Test C and went from 223 up to 242lbs. Calories were well over 3500 a day. Been cruising on 500 mg Sus a week since Jan till I start my cut cycle in 2 weeks. I have cleaned up my diet similar to what Im going to eat during my cut phase (2500 to 3000cal) and I am dropping weight like crazy. Im talking like 17lbs in a couple months. Im looking alot more defined as well as some striations are visible now in my chest and delts. Water weight like the bloat face has gone down alot. When you come off a Test cycle to a lower Cruise is it common to loose that much weight or am I loosing muscle I literally busted my ass to get? Thank you bro.

 

[christoulla@optu]

What I would like to know is with a rotator cuff tear are you limited with Weight Training ???

 

[MuscleGauge1]

You know there is going to be some terminator jokes come out now.

I was just thinking this! LOL

 

[sofargone561]

What I would like to know is with a rotator cuff tear are you limited with Weight Training ???

is it healed? im no expert but i tore mine and i do not have to limit my trianing but i do have to make sure that i am not very slow and have good form on certain work outs or i will be in great pain

 

[swollen]

Sup Heavy,
I'm kinda torn between PCT & cruise'n. Can you cruise on tren? & if so, what dose and should I use clomid from using test?

 

[Ezskanken]

Heavy,

I started my HCG a couple weeks ago. Literally 2 days after my first HCG injection (500iu twice a week) my shoulders and traps broke out in small pimples. Previous to that I've been on a 500mg/week test e cycle taking 12.5mg aromasin eod and been "bacne" free. When I started the HCG I also increased my aromasin to 12.5mg ed. Wife doesn't like the pimples on me one bit, ha ha.

It doesn't seem to be improving, it's been almost 2 weeks now. Does my body need more time to adjust to the HCG, and eventually the pimples will subside? Or should I split my doses up into smaller ones and inject more often? Or something else?

Thanks Heavy

 

[heavyiron]

like shit lol heres my estro results

Component Your Value Standard Range Units
Estrone, LC/MS/MS 77
Reference range: < OR = 68
Unit: pg/mL
Estradiol, LC/MS/MS 46
Reference range: < OR = 29
Unit: pg/mL
Estriol, LC/MS/MS <0.10
Unit: ng/mL
(Note)
Ref. range: ADULTS: < OR = 0.18

This is on letro at 2.5 mgs ed so I am bummed, i thought the letro i had was g2g, Trying to get estro under conrol, had the post cycle crash going on tuesday to get estro and test levels agian. Water weight at waste still their doing everything i can.... Am on formeron now getting bloods drawn tuesday. On 4 pumps ed formeron and 40 mg nolva and natty test booster.

SERMs will raise E2 so your Letro may be fine brother. Retest without the SERM to be sure.

 

[heavyiron]

john me and my wife have a question, we are both 52 active, execise and live healthy, i have liver issues not serious at this time, im also running test at 750mgs a week our question concerns hgh releasers, a natural hgh stimulator, a couple im looking at are gen force, and secratropin hgh can these products cause the pituitary gland to release and raise hgh levels in a way that would be seen in its results (scam or legit) i know this may not be youre expertiese but these products are expensive and would like a heads up from a reliable source who i consider you to be

There are many GH releasers on the market and unfortunately I'm not familiar with these. They may or may not work. I would strongly recommend using HGH instead. At your ages I think that would be the most beneficial and only a low dose of 1-3iu GH would be needed 5-6 days per week.

 

[heavyiron]

Ok, tnx Heavy!

If I'm preping for a specific date and have access to only Mast Enanthate, how many weeks before that should I start using it to see the full effect?

The final 6-8 weeks would be ideal brother.

 

[heavyiron]

What I would like to know is with a rotator cuff tear are you limited with Weight Training ???

It depends on the severity. I would consult a doctor and follow their advice exactly. These types of injuries can get much worse if you are not careful.

 

[_LG_]

Heavy,
Any hard evidence or personal experience with negative side effects from using nolva while on tren? Short or long term?

 

[Rednack]

I'm reading different points of view over the fact about how many days apart for max results, should you work a single body part in a week..

You're opinion would be greatly appreciated..

 

[squigader]

This'll be a change - instead of a question about AAS, how about training? If you could only pick one crucial exercise for each body part, what would it be?

Chest -
Back -
Legs - (Squats, you don't need to answer this one )
Calves -
Shoulders -
Core/Abs -
Biceps -
Triceps -
Forearms -

 

[heavyiron]

Sup Heavy,
I'm kinda torn between PCT & cruise'n. Can you cruise on tren? & if so, what dose and should I use clomid from using test?

This is a big decision and you need to carefully think it through because years from now you may not be in the same mind set as you are now. However if you decide to cruise, Tren may not be the best choice. Interestingly, Tren has been studied as an option for androgen replacement therapy. However more studies are needed. It's my opinoin at this time that Testosterone would be a better choice.

Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E650-60. Epub 2011 Jan 25.
17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate.

Yarrow JF, Conover CF, McCoy SC, Lipinska JA, Santillana CA, Hance JM, Cannady DF, VanPelt TD, Sanchez J, Conrad BP, Pingel JE, Wronski TJ, Borst SE.
Source

VA Medical Center, University of Florida, Gainesville, 32608-1197, USA. jfyarrow@ufl.edu

Abstract

Selective androgen receptor modulators (SARMs) now under development can protect against muscle and bone loss without causing prostate growth or polycythemia. 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone), a potent testosterone analog, may have SARM-like actions because, unlike testosterone, trenbolone does not undergo tissue-specific 5α-reduction to form more potent androgens. We tested the hypothesis that trenbolone-enanthate (TREN) might prevent orchiectomy-induced losses in muscle and bone and visceral fat accumulation without increasing prostate mass or resulting in adverse hemoglobin elevations. Male F344 rats aged 3 mo underwent orchiectomy or remained intact and were administered graded doses of TREN, supraphysiological testosterone-enanthate, or vehicle for 29 days. In both intact and orchiectomized animals, all TREN doses and supraphysiological testosterone-enanthate augmented androgen-sensitive levator ani/bulbocavernosus muscle mass by 35-40% above shams (P ≤ 0.001) and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (P < 0.05) and visceral fat accumulation (P < 0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concentrations at sham levels in both intact and orchiectomized animals, whereas supraphysiological testosterone-enanthate and high-dose TREN elevated prostate mass by 84 and 68%, respectively (P < 0.01). In summary, low-dose administration of the non-5α-reducible androgen TREN maintains prostate mass and hemoglobin concentrations near the level of shams while producing potent myotrophic actions in skeletal muscle and partial protection against orchiectomy-induced bone loss and visceral fat accumulation. Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy.

PMID:21266670 [PubMed - indexed for MEDLINE]

 

[heavyiron]

Heavy,

I started my HCG a couple weeks ago. Literally 2 days after my first HCG injection (500iu twice a week) my shoulders and traps broke out in small pimples. Previous to that I've been on a 500mg/week test e cycle taking 12.5mg aromasin eod and been "bacne" free. When I started the HCG I also increased my aromasin to 12.5mg ed. Wife doesn't like the pimples on me one bit, ha ha.

It doesn't seem to be improving, it's been almost 2 weeks now. Does my body need more time to adjust to the HCG, and eventually the pimples will subside? Or should I split my doses up into smaller ones and inject more often? Or something else?

Thanks Heavy

Manipulating hormones will increase oil output and therefore increase acne. Unfortunately this is the nature of using steroids and ancillaries. HCG will raise T levels and can aromatize. Your HCG doses are fine. I would use acne washes and possibly tan to reduce acne. If this is not enough a more aggressive approach like Accutane may be needed brother.

 

[heavyiron]

Heavy,
Any hard evidence or personal experience with negative side effects from using nolva while on tren? Short or long term?

No, there are some concerns with progesterone receptor up regulation but it is only temporary and may not be a problem at all.

In the cancer subjects that upregulation of PGR occurs, 100% see down regulation after 4 weeks of Nolva.

Cancer Res. 1981 May;41(5):1984-8.

Effects of tamoxifen on estrogen and progesterone receptors in human breast cancer.

Waseda N, Kato Y, Imura H, Kurata M.

Abstract

Twenty patients with primary breast cancer were treated with tamoxifen (10 mg p.o. twice a day) for 1 to 4 weeks. Before and after the tamoxifen administration, tumor specimens were obtained and assayed for estrogen receptors and progesterone receptors (PGR). Total cytosol estrogen receptor (ERC) and occupied nuclear estrogen receptor (ERN) were measured by hydroxylapatite assay, and unoccupied PGR was measured by the dextran-coated charcoal assay. ERC, ERN, and PGR were detectable in 11, 8, and 6 tumors, respectively, before tamoxifen administration. After tamoxifen treatment, ERC decreased in 10 of 11 ERC-positive tumors. Occupied ERN increased in three of five ERN-positive tumors treated with tamoxifen for a short period (1 to 2 weeks), but they decreased in all of three ERN-positive tumors after longer administration (3 to 4 weeks). PGR increased in three of five ERN-positive tumors after short-term tamoxifen treatment, but they decreased in all of three tumors treated by the drug for a longer period. Increased PGR responses were accompanied by an increase of ERN in two of three ERN-positive tumors. These results suggest that tamoxifen interacts with the estrogen receptor system in human breast cancer tissue and may be estrogenic during short treatment, while longer treatment results in an antiestrogenic response.

PMID:7214366 [PubMed - indexed for MEDLINE]

 

[heavyiron]

I'm reading different points of view over the fact about how many days apart for max results, should you work a single body part in a week..

You're opinion would be greatly appreciated..

Without AAS, training each body part once per week is generally advised. With AAS you may be able to do a couple body parts more than once per week but nutrition and rest need to be very dialed in brother.

 

[_LG_]

Thanks Heavy,
If guys would read this kind of thing instead of listening to the broscience everywhere we would all be more educated.

No, there are some concerns with progesterone receptor up regulation but it is only temporary and may not be a problem at all.

In the cancer subjects that upregulation of PGR occurs, 100% see down regulation after 4 weeks of Nolva.

Cancer Res. 1981 May;41(5):1984-8.

Effects of tamoxifen on estrogen and progesterone receptors in human breast cancer.

Waseda N, Kato Y, Imura H, Kurata M.

Abstract

Twenty patients with primary breast cancer were treated with tamoxifen (10 mg p.o. twice a day) for 1 to 4 weeks. Before and after the tamoxifen administration, tumor specimens were obtained and assayed for estrogen receptors and progesterone receptors (PGR). Total cytosol estrogen receptor (ERC) and occupied nuclear estrogen receptor (ERN) were measured by hydroxylapatite assay, and unoccupied PGR was measured by the dextran-coated charcoal assay. ERC, ERN, and PGR were detectable in 11, 8, and 6 tumors, respectively, before tamoxifen administration. After tamoxifen treatment, ERC decreased in 10 of 11 ERC-positive tumors. Occupied ERN increased in three of five ERN-positive tumors treated with tamoxifen for a short period (1 to 2 weeks), but they decreased in all of three ERN-positive tumors after longer administration (3 to 4 weeks). PGR increased in three of five ERN-positive tumors after short-term tamoxifen treatment, but they decreased in all of three tumors treated by the drug for a longer period. Increased PGR responses were accompanied by an increase of ERN in two of three ERN-positive tumors. These results suggest that tamoxifen interacts with the estrogen receptor system in human breast cancer tissue and may be estrogenic during short treatment, while longer treatment results in an antiestrogenic response.

PMID:7214366 [PubMed - indexed for MEDLINE]