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Aspertame

VMSEddieF

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Guys, ive recently been diagnosed with MS. Been to 2 neurologists, 1 a old timer specialist 1 1/2 hrs away. They cant know everything, and to get the job done right ya gotta do it yourself, so with my research i found what may be intesting to you's that might be watching calorie intake. If this is true, there should be warnings on diet soda and sweetner products. Just lookin out for you guys. I just found this article and am in shock.

http://www.rense.com/general53/ms.htm
 
Aspartame is an analog of NMDA. NMDA is a neurotransmitter and has its own receptors types. NMDA is also glutamate receptor activator. Thus, this compound is neurologically active. It is a key nerve activator in the GI tract. It plays a role in GI disease. GI disease affects nutritional status, and this affects health. Excess of any supplement that acts on brain, liver, GI tract, such as glutamine, aspartic acid, or arginine, will have consequences on health.
 
Sorry to hear about your diagnosis.

How much aspartame where you taking in daily?
 
This is the 3rd person on the forum who has openly stated they have been diagnosed with MS. How common is this?
 
P-funk said:
Sorry to hear about your diagnosis.

How much aspartame where you taking in daily?

I dont know. It's in a drink mix ive taken for last 5 yrs as a sweetener I assume. It could be harmless to the average person for all i know since my Aunt has drank nothing but diet soda for ever. I say go with the extra calories and burn em off. I neglected working out for last 3 yrs being so busy and that was a mistake. No doubt if i get the chance to recover which i may since i caught it in very early stage im never going weak again. Got to keep that blood flowing!
 
Eddie, you will please read up on dietary corrections to enhance natural glutathione production. Read up on GABA, and excitatory brain chemistry.

Come back here and ask questions if you need to, but I'd like to see you do your own reading on the connection between neurodegenerative disorders and low glutathione and GABA status.

Meditation, proper rest, exercise and stress control are essential, alongside use of glutathione/methylation and antioxidant supplements.

http://www.msrc.co.uk/index.cfm?fuseaction=show&pageid=652

http://www.multiple-sclerosis-and-glutathione.com/

These lesions are slowly reversible; the degeneratiive condition can be halted and held in remission for extended periods of time.
 
yikes, I have recently given up aspartame due to all the serious literature I've read. I had been chewing up to 5 sticks of sugarfree (aspartame) gum a day. I hope I didn't do too much damage :(

Is sucralose/splenda AS dangerous? I try to split up my sweeteners between splenda and stevia.

Eddie, what aspartame containing products did you consume?
 
some people say "oh its not enough to harm you" Yeah but over a long period , Things can change. This crap causes cancer. Its in 95% of the protein shakes out there.
 
Aspartame Is Poison

Here is some info on the subject of artificial sweetners:

Aspartame is basically poison. so is Sweeta. Here's a small excerpt form Dr. Joeseph Mercola's web site, under an article titled:

ASPARTAME IS BY FAR, THE MOST DANGEROUS SUBSTANCE ON THE MARKET THAT IS ADDED TO FOODS

SUMMARY OF HOW ASPARTATE (AND GLUTAMATE) CAUSE DAMAGE

Aspartate and glutamate act as neurotransmitters in the brain by facilitating the transmission of information from neuron to neuron. Too much aspartate or glutamate in the brain kills certain neurons by allowing the influx of too much calcium into the cells. This influx triggers excessive amounts of free radicals which kill the cells. The neural cell damage that can be caused by excessive aspartate and glutamate is why they are referred to as "excitotoxins." They "excite" or stimulate the neural cells to death. Aspartic acid is an amino acid. Taken in its free form (unbound to proteins) it significantly raises the blood plasma level of aspartate and glutamate. The excess aspartate and glutamate in the blood plasma shortly after ingesting aspartame or products with free glutamic acid (glutamate precursor) leads to a high level of those neurotransmitters in certain areas of the brain. The blood brain barrier (BBB) which normally protects the brain from excess glutamate and aspartate as well as toxins 1) is not fully developed during childhood, 2) does not fully protect all areas of the brain, 3) is damaged by numerous chronic and acute conditions, and 4) allows seepage of excess glutamate and aspartate into the brain even when intact. The excess glutamate and aspartate slowly begin to destroy neurons. The large majority (75%+) of neural cells in a particular area of the brain are killed before any clinical symptoms of a chronic illness are noticed. A few of the many chronic illnesses that have been shown to be contributed to by long-term exposure excitatory amino acid damage include: Multiple sclerosis (MS), ALS, memory loss, hormonal problems, hearing loss, epilepsy, Alzheimer's disease, Parkinson's disease, hypoglycemia, AIDS dementia, brain lessions, and neuroendocrine disorders."

As bad as that sounds the latest research results are even worse.This is the first line from the abstract, "The Cesare Maltoni Cancer Research Center of the European Ramazzini Foundation has conducted a long-term bioassay on aspartame (APM), a widely used artificial sweetener." This study was seven years long. The abstract goes on to describe the parameters of the study and finishes with this conclusion, "The results of this mega-experiment indicate that APM is a multipotential carcinogenic agent, even at a daily dose of 20 mg/kg body weight, much less than the current acceptable daily intake. On the basis of these results, a reevaluation of the present guidelines on the use and consumption of APM is urgent and cannot be delayed."
-Environ Health Perspect 114:379-385 (2006).

This is only the tip of the proverbial iceberg.

VMSEddieF, you have my profound sympathy. Aspartame becomes formaldehyde and then formic acid in the human body. It does brain and nerve damage. You may ameloriate some of the damage with L-Carnitine. I recommend Global Health Trax liquid L-Carnitine, but I am biased. I used to be a consultant for the company and I know how good their stuff is. If there is sufficient interest I will be happy to provide further data, links and research citations.

Ubercoach
 
I read those links Trouble. Thanks. Not a MS thread so i'll stick with topic.

Ubercoach i know. I couldnt believe how bad aspartame is when i started searching it. Im sure everybody handles it different but for the sake of 100 calories jeeze...these manufacturers.

I bet theres not 1 guy in here that wouldnt do extra cardio for the sake of health and 100 more calories.

My favorite gum i noticed is sugar free. Sucked to toss 10 packs in trash.
 
Muscle Gelz Transdermals
IronMag Labs Prohormones
Great aspertame is in my dissolve on your tongue Migraine pills, I'm gonna diiiiieeeeee!!!!
 
This is the 3rd person on the forum who has openly stated they have been diagnosed with MS. How common is this?

Quite common. I know a few people that have it. Women tend to get it more than men. I don't know why though.
 
The demonization of Aspartame seems unwarranted

"The overwhelming body of scientific evidence clearly demonstrates that aspartame, even in amounts many times what people typically consume, is safe and not associated with adverse health effects. However, over the years, some consumers have reported symptoms, which they believed were associated with aspartame. The FDA has investigated these allegations and concluded that there is no "reasonable evidence of possible public health harm" and "no consistent or unique patterns of symptoms reported with respect to aspartame that can be causally linked to its use." In 1984, the Centers for Disease Control (CDC) reviewed 517 of these anecdotal reports and stated, "the majority of frequently reported symptoms were mild and are symptoms that are common in the general populace" and that ???focused??? clinical studies would be the best way to evaluate these complaints.

As a result, numerous scientific studies ???focused??? on the allegations were conducted by expert researchers at major academic institutions. The results of these studies overwhelmingly demonstrated that aspartame is not associated with adverse health effects, including headaches, seizures, changes in mood, cognition, or behavior, or allergic reactions.

Despite the overwhelming documentation of aspartame???s safety, unfounded allegations that aspartame is associated with a myriad of ailments, including multiple sclerosis, Parkinson???s disease, Alzheimer???s disease, and lupus, have continued to be spread via the Internet and the media by a few individuals who have no documented scientific or medical expertise. Recently, several governments and expert scientific committees (including the Scientific Committee on Food of the European Commission, the United Kingdom???s Food Standards Agency, the French Food Safety Agency and Health Canada) carefully evaluated the Internet allegations and found them to be false, reconfirming the safety of aspartame. In addition, leading health authorities, such as the Multiple Sclerosis Foundation, The National Multiple Sclerosis Society, The National Parkinson Foundation, Inc., the Alzheimer???s Association, and the Lupus Foundation of America, have reviewed the claims on the Internet and also concluded that they are false."

http://www.aspartame.org/aspartame_myths.html
 
Bold Assertion

"When aspartame is digested, the body breaks it down into its components, aspartic acid, phenylalanine and methanol, which are consumed in much greater amounts in common foods, such as milk, meat, dried beans, fruits and vegetables. The body handles the components from aspartame in the same way it handles them when derived from other foods. Aspartame does not enter the bloodstream and therefore cannot travel to essential organs including the brain. Thus, there is no physiological reason why aspartame could cause cancer."

http://www.aspartame.org/aspartame_myths_brain.html



"Aspartame becomes formaldehyde and then formic acid in the human body. It does brain and nerve damage. You may ameloriate some of the damage with L-Carnitine. I recommend Global Health Trax liquid L-Carnitine, but I am biased. I used to be a consultant for the company and I know how good their stuff is. If there is sufficient interest I will be happy to provide further data, links and research citations."
 
The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity. Pharmacol Res. 2006 Jan;53(1):1-5.

Tsakiris S, Giannoulia-Karantana A, Simintzi I and Schulpis KH.

Studies have implicated aspartame (ASP) with neurological problems. The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. ..

... It is concluded that low concentrations of ASP metabolites had no effect on the membrane enzyme activity, whereas high or toxic concentrations partially or remarkably decreased the membrane AChE activity, respectively. Additionally, neurological symptoms, including learning and memory processes, may be related to the high or toxic concentrations of the sweetener metabolites.

(eg, there is a dose dependent effect on acetylcholinesterase activity. It has also been shown to affect AMPK and NMDA receptors activity associated with LTP - memory processing in the forebrain - also a dose dependent condition.

Note: many whey products are formulated with sucralose, not aspartame.
 
or not

Arch Intern Med. 1989 Oct;149(10):2318-24.

Safety of long-term large doses of aspartame.

Leon AS, Hunninghake DB, Bell C, Rassin DK, Tephly TR.

Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis.

Safety of long-term administration of 75 mg/kg of aspartame per day was evaluated with the use of a randomized, double-blind, placebo-controlled, parallel-group design in 108 male and female volunteers aged 18 to 62 years. Subjects received either aspartame or placebo in capsule form three times daily for 24 weeks. No persistent changes over time were noted in either group in vital signs; body weight; results of standard laboratory tests; fasting blood levels of aspartame's constituent amino acids (aspartic acid and phenylalanine), other amino acids, and methanol; or blood formate levels and 24-hour urinary excretion of formate. There also were no statistically significant differences between groups in the number of subjects experiencing symptoms or in the number of symptoms per subject. These results further document the safety of the long-term consumption of aspartame at doses equivalent to the amount of aspartame in approximately 10 L of beverage per day.



Pediatrics. 1990 Jul;86(1):75-83.

Aspartame: effects on learning, behavior, and mood.

Saravis S, Schachar R, Zlotkin S, Leiter LA, Anderson GH.

Department of Medicine, University of Toronto, Ontario, Canada.

The effect of aspartame on the learning, behavior, and mood of children was evaluated in two experiments. After an overnight fast and a standard breakfast, 20 healthy 9- to 10-year-old children were given the treatments in a double-blind crossover design at 10:30 AM. Lunch was served at 12:00 noon. In experiment 1, the treatment consisted of an ice slurry of strawberry Kool-Aid containing 1.75 g/kg of carbohydrate (polycose) plus either aspartame (34 mg/kg) or the equivalent sweetness as sodium cyclamate and amino acids as alanine. In experiment 2, the treatment consisted of a drink of cold unsweetened strawberry Kool-Aid, containing either 1.75 g/kg of sucrose or 9.7 mg/kg of aspartame. Measures of associative learning, arithmetic calculation, activity level, social interaction, and mood were unaffected by treatment in experiment 1. In experiment 2, the only significant treatment effect was that on the frequency of minor and gross motor behaviors, which were less frequent after the consumption of sucrose than after aspartame. Thus, the effect of aspartame on the short-term behavior of healthy 9- to 10-year-old children appears to be related to its absence of metabolic consequences rather than to its amino acid composition and putative neurochemical impact.


Am J Clin Nutr. 1995 Dec;62(6):1206-11.

Erythrocyte L-aspartyl-L-phenylalanine hydrolase activity and plasma phenylalanine and aspartate concentrations in children consuming diets high in aspartame.

Stegink LD, Lindgren SD, Brummel MC, Stumbo PJ, Wolraich ML.

Department of Pediatrics, University of Iowa College of Medicine, Iowa City, USA.

A deficit of alpha-aspartyl-phenylalanine (alpha-Asp-Phe) hydrolase activity has been suggested as a cause of possible adverse effects of aspartame ingestion. Twenty-five normal preschool children and 23 school-age children described by their parents as sensitive to sugar were fed diets high in sucrose, aspartame, or saccharin for three successive 3-wk periods. Blood samples were obtained at baseline (fasting) and within the last 3 d of each dietary period (postprandial). alpha-Asp-Phe concentrations were below detection limits (0.5 mumol/L) in all plasma samples and Phe and Asp concentrations remained within normal limits, alpha-Asp-Phe hydrolase activities in baseline hemolysate samples did not differ between groups. One subject had a plasma alpha-Asp-Phe hydrolase activity > 2 SD below the mean. Despite this low activity, this subject did not show consistent cognitive or behavioral anomalies that could be linked to low hydrolase activity.
 
Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. Toxicol Sci. 2006 90(1):178-87.

Lau K, McLean WG, Williams DP and Howard CV.

Developmental Toxicopathology Unit, Department of Human Anatomy & Cell Biology, University of Liverpool UK.

Exposure to non-nutritional food additives during the critical development window has been implicated in the induction and severity of behavioral disorders such as attention deficit hyperactivity disorder (ADHD). Although the use of single food additives at their regulated concentrations is believed to be relatively safe in terms of neuronal development, their combined effects remain unclear. We therefore examined the neurotoxic effects of four common food additives in combinations of two (Brilliant Blue and L-glutamic acid, Quinoline Yellow and aspartame) to assess potential interactions. Mouse NB2a neuroblastoma cells were induced to differentiate and grow neurites in the presence of additives. After 24 h, cells were fixed and stained and neurite length measured by light microscopy with computerized image analysis. Neurotoxicity was measured as an inhibition of neurite outgrowth. Two independent models were used to analyze combination effects: effect additivity and dose additivity. Significant synergy was observed between combinations of Brilliant Blue with L-glutamic acid, and Quinoline Yellow with aspartame, in both models. Involvement of N-methyl-D-aspartate (NMDA) receptors in food additive-induced neurite inhibition was assessed with a NMDA antagonist, CNS-1102. L-glutamic acid- and aspartame-induced neurotoxicity was reduced in the presence of CNS-1102; however, the antagonist did not prevent food color-induced neurotoxicity. Theoretical exposure to additives was calculated based on analysis of content in foodstuff, and estimated percentage absorption from the gut. Inhibition of neurite outgrowth was found at concentrations of additives theoretically achievable in plasma by ingestion of a typical snack and drink. In addition, Trypan Blue dye exclusion was used to evaluate the cellular toxicity of food additives on cell viability of NB2a cells; both combinations had a straightforward additive effect on cytotoxicity. These data have implications for the cellular effects of common chemical entities ingested individually and in combination.

I've never seen it used by itself, as a supplement. A foolish way to test it, in as much as NMDA/glutamate are known CNS activators of gut activity - and more importantly, play a role in active uptake and co-transport of many ions and compounds.
 
Mikey Doesn't Like It...

From Dr. Mercola's web site:

Aspartic Acid (40 percent of aspartame)

Dr. Russell L. Blaylock, a professor of neurosurgery at the Medical University of Mississippi, recently published a book thoroughly detailing the damage that is caused by the ingestion of excessive aspartic acid from aspartame. Blaylock makes use of almost 500 scientific references to show how excess free excitatory amino acids such as aspartic acid and glutamic acid (about 99 percent of monosodium glutamate (MSG) is glutamic acid) in our food supply are causing serious chronic neurological disorders and a myriad of other acute symptoms.(3)


How Aspartate (and Glutamate) Cause Damage

Aspartate and glutamate act as neurotransmitters in the brain by facilitating the transmission of information from neuron to neuron. Too much aspartate or glutamate in the brain kills certain neurons by allowing the influx of too much calcium into the cells. This influx triggers excessive amounts of free radicals, which kill the cells. The neural cell damage that can be caused by excessive aspartate and glutamate is why they are referred to as "excitotoxins." They "excite" or stimulate the neural cells to death.

Aspartic acid is an amino acid. Taken in its free form (unbound to proteins) it significantly raises the blood plasma level of aspartate and glutamate. The excess aspartate and glutamate in the blood plasma shortly after ingesting aspartame or products with free glutamic acid (glutamate precursor) leads to a high level of those neurotransmitters in certain areas of the brain.

The blood brain barrier (BBB), which normally protects the brain from excess glutamate and aspartate as well as toxins, 1) is not fully developed during childhood, 2) does not fully protect all areas of the brain, 3) is damaged by numerous chronic and acute conditions, and 4) allows seepage of excess glutamate and aspartate into the brain even when intact.

The excess glutamate and aspartate slowly begin to destroy neurons. The large majority (75 percent or more) of neural cells in a particular area of the brain are killed before any clinical symptoms of a chronic illness are noticed. A few of the many chronic illnesses that have been shown to be contributed to by long-term exposure to excitatory amino acid damage include:

Multiple sclerosis (MS)
ALS
Memory loss
Hormonal problems
Hearing loss
Epilepsy
Alzheimer's disease
Parkinson's disease
Hypoglycemia
AIDS
Dementia
Brain lesions
Neuroendocrine disorders
The risk to infants, children, pregnant women, the elderly and persons with certain chronic health problems from excitotoxins are great. Even the Federation of American Societies for Experimental Biology (FASEB), which usually understates problems and mimics the FDA party-line, recently stated in a review that:

"It is prudent to avoid the use of dietary supplements of L-glutamic acid by pregnant women, infants, and children. The existence of evidence of potential endocrine responses, i.e., elevated cortisol and prolactin, and differential responses between males and females, would also suggest a neuroendocrine link and that supplemental L-glutamic acid should be avoided by women of childbearing age and individuals with affective disorders."(4)

Aspartic acid from aspartame has the same deleterious effects on the body as glutamic acid.

The exact mechanism of acute reactions to excess free glutamate and aspartate is currently being debated. As reported to the FDA, those reactions include:(5)

Headaches/migraines
Nausea
Abdominal pains
Fatigue (blocks sufficient glucose entry into brain)
Sleep problems
Vision problems
Anxiety attacks
Depression
Asthma/chest tightness.
One common complaint of persons suffering from the effect of aspartame is memory loss. Ironically, in 1987, G.D. Searle, the manufacturer of aspartame, undertook a search for a drug to combat memory loss caused by excitatory amino acid damage. Blaylock is one of many scientists and physicians who are concerned about excitatory amino acid damage caused by ingestion of aspartame and MSG.

A few of the many experts who have spoken out against the damage being caused by aspartate and glutamate include Adrienne Samuels, Ph.D., an experimental psychologist specializing in research design. Another is Olney, a professor in the department of psychiatry, School of Medicine, Washington University, a neuroscientist and researcher, and one of the world's foremost authorities on excitotoxins. (He informed Searle in 1971 that aspartic acid caused holes in the brains of mice.)

Phenylalanine (50 percent of aspartame)

Phenylalanine is an amino acid normally found in the brain. Persons with the genetic disorder phenylketonuria (PKU) cannot metabolize phenylalanine. This leads to dangerously high levels of phenylalanine in the brain (sometimes lethal). It has been shown that ingesting aspartame, especially along with carbohydrates, can lead to excess levels of phenylalanine in the brain even in persons who do not have PKU.

This is not just a theory, as many people who have eaten large amounts of aspartame over a long period of time and do not have PKU have been shown to have excessive levels of phenylalanine in the blood. Excessive levels of phenylalanine in the brain can cause the levels of seratonin in the brain to decrease, leading to emotional disorders such as depression. It was shown in human testing that phenylalanine levels of the blood were increased significantly in human subjects who chronically used aspartame.(6)

Even a single use of aspartame raised the blood phenylalanine levels. In his testimony before the U.S. Congress, Dr. Louis J. Elsas showed that high blood phenylalanine can be concentrated in parts of the brain and is especially dangerous for infants and fetuses. He also showed that phenylalanine is metabolised much more effeciently by rodents than by humans.(7)

One account of a case of extremely high phenylalanine levels caused by aspartame was recently published the "Wednesday Journal" in an article titled "An Aspartame Nightmare." John Cook began drinking six to eight diet drinks every day. His symptoms started out as memory loss and frequent headaches. He began to crave more aspartame-sweetened drinks. His condition deteriorated so much that he experienced wide mood swings and violent rages. Even though he did not suffer from PKU, a blood test revealed a phenylalanine level of 80 mg/dl. He also showed abnormal brain function and brain damage. After he kicked his aspartame habit, his symptoms improved dramatically.(8)

As Blaylock points out in his book, early studies measuring phenylalanine buildup in the brain were flawed. Investigators who measured specific brain regions and not the average throughout the brain notice significant rises in phenylalanine levels. Specifically the hypothalamus, medulla oblongata, and corpus striatum areas of the brain had the largest increases in phenylalanine. Blaylock goes on to point out that excessive buildup of phenylalanine in the brain can cause schizophrenia or make one more susceptible to seizures.

Therefore, long-term, excessive use of aspartame may provid a boost to sales of seratonin reuptake inhibitors such as Prozac and drugs to control schizophrenia and seizures.

Methanol (aka wood alcohol/poison) (10 percent of aspartame)

Methanol/wood alcohol is a deadly poison. Some people may remember methanol as the poison that has caused some "skid row" alcoholics to end up blind or dead. Methanol is gradually released in the small intestine when the methyl group of aspartame encounter the enzyme chymotrypsin.

The absorption of methanol into the body is sped up considerably when free methanol is ingested. Free methanol is created from aspartame when it is heated to above 86 Fahrenheit (30 Centigrade). This would occur when aspartame-containing product is improperly stored or when it is heated (e.g., as part of a "food" product such as Jello).

Methanol breaks down into formic acid and formaldehyde in the body. Formaldehyde is a deadly neurotoxin. An EPA assessment of methanol states that methanol "is considered a cumulative poison due to the low rate of excretion once it is absorbed. In the body, methanol is oxidized to formaldehyde and formic acid; both of these metabolites are toxic." They recommend a limit of consumption of 7.8 mg/day. A one-liter (approx. 1 quart) aspartame-sweetened beverage contains about 56 mg of methanol. Heavy users of aspartame-containing products consume as much as 250 mg of methanol daily or 32 times the EPA limit.(9)

Symptoms from methanol poisoning include headaches, ear buzzing, dizziness, nausea, gastrointestinal disturbances, weakness, vertigo, chills, memory lapses, numbness and shooting pains in the extremities, behavioral disturbances, and neuritis. The most well known problems from methanol poisoning are vision problems including misty vision, progressive contraction of visual fields, blurring of vision, obscuration of vision, retinal damage, and blindness. Formaldehyde is a known carcinogen, causes retinal damage, interferes with DNA replication and causes birth defects.(10)

Due to the lack of a couple of key enzymes, humans are many times more sensitive to the toxic effects of methanol than animals. Therefore, tests of aspartame or methanol on animals do not accurately reflect the danger for humans. As pointed out by Dr. Woodrow C. Monte, director of the food science and nutrition laboratory at Arizona State University, "There are no human or mammalian studies to evaluate the possible mutagenic, teratogenic or carcinogenic effects of chronic administration of methyl alcohol."(11)

He was so concerned about the unresolved safety issues that he filed suit with the FDA requesting a hearing to address these issues. He asked the FDA to "slow down on this soft drink issue long enough to answer some of the important questions. It's not fair that you are leaving the full burden of proof on the few of us who are concerned and have such limited resources. You must remember that you are the American public's last defense. Once you allow usage (of aspartame) there is literally nothing I or my colleagues can do to reverse the course. Aspartame will then join saccharin, the sulfiting agents, and God knows how many other questionable compounds enjoined to insult the human constitution with governmental approval."(10) Shortly thereafter, the Commissioner of the FDA, Arthur Hull Hayes, Jr., approved the use of aspartame in carbonated beverages, he then left for a position with G.D. Searle's public relations firm.(11)

It has been pointed out that some fruit juices and alcoholic beverages contain small amounts of methanol. It is important to remember, however, that methanol never appears alone. In every case, ethanol is present, usually in much higher amounts. Ethanol is an antidote for methanol toxicity in humans.(9) The troops of Desert Storm were "treated" to large amounts of aspartame-sweetened beverages, which had been heated to over 86 degrees F in the Saudi Arabian sun. Many of them returned home with numerous disorders similar to what has been seen in persons who have been chemically poisoned by formaldehyde. The free methanol in the beverages may have been a contributing factor in these illnesses. Other breakdown products of aspartame such as DKP (discussed below) may also have been a factor.

In a 1993 act that can only be described as "unconscionable," the FDA approved aspartame as an ingredient in numerous food items that would always be heated to above 86 degree F (30 degree C).

Diketopiperazine (DKP)

DKP is a byproduct of aspartame metabolism. DKP has been implicated in the occurrence of brain tumors. Olney noticed that DKP, when nitrosated in the gut, produced a compound that was similar to N-nitrosourea, a powerful brain tumor causing chemical. Some authors have said that DKP is produced after aspartame ingestion. I am not sure if that is correct. It is definitely true that DKP is formed in liquid aspartame-containing products during prolonged storage.

G.D. Searle conducted animal experiments on the safety of DKP. The FDA found numerous experimental errors occurred, including "clerical errors, mixed-up animals, animals not getting drugs they were supposed to get, pathological specimens lost because of improper handling," and many other errors.(12) These sloppy laboratory procedures may explain why both the test and control animals had sixteen times more brain tumors than would be expected in experiments of this length.

In an ironic twist, shortly after these experimental errors were discovered, the FDA used guidelines recommended by G.D. Searle to develop the industry-wide FDA standards for good laboratory practices.(11)

DKP has also been implicated as a cause of uterine polyps and changes in blood cholesterol by FDA Toxicologist Dr. Jacqueline Verrett in her testimony before the U.S. Senate.(13)

Ubercoach
 
Last edited:
Interview With M. Stoddard, Author

Author, Mary Nash Stoddard presented research findings at Tesla Conference, July '95, Colorado Springs CO before several hundred attendees. Lecture available on video by contacting ACSN 1-800-969-6050

This article was written based partially on the evidence presented in these studies/medical and scientific texts:

National Cancer Institute Cancer Statistics Review 1973-87. Bethesda, N111 Pub. No. 89-2789 Roberts, H.J.; Does Aspartame Cause Human Brain Cancer?. Journal of Advancements in Medicine. Vol. 4, No. 4, Winter 1991 W.C. Monte, Aspartame: Methanol and the Public Health. Journal of Applied Nutrition, Vol. 36, No. 1, 1984. P.J. Shaw, Excitatory amino acid receptors, excitotoxicity, and the human nervous system. Current Opinion in Neurology and Neurosurgery 1993, 6:414-422 UK T.J. Maher and R.J. Wurtman, Possible Neurologic Effects of Aspartame, a Widely Used Food Additive. Environmental Health Perspectives. Vo. 75, p. 53-57, 1987. M.E. Drake, Panic Attacks and Excessive Aspartame Ingestion. p. 631 The Lancet, Sept. 13, 1986 Congressional Record, Senate. Saccharin Study and Labeling Act Amendments of 1985. May 7,m 1985, p. S5489-5516 Congressional Record Senate. Aspartame Safety Act of 1985. August 1, 1985, p. S10820-10847 Ishu, II: Incidence of brain tumors in rats fed aspartame. Toxicol Letters 1981, 7:433-437. R.G. Walton, Seizure and Mania after high intake of aspartame. Psychomatics, 1986; 27:218-220 R.J. Wurtman, E.R.Walker, Dietary Phenylalanine and Brain Function, MIT Press May, 1988. D. Remington, B. Higa, The Bitter truth About Artificial Sweeteners. Vitality House Press, 1987 H.J. Roberts, Aspartame, NutraSweet. Is It Safe? The Charles Press, December 1989. B.A. Mullarkey, Bittersweet Aspartame, A Diet Delusion. NutriVoice, Inc. ISBN 0-944366 -- 00-7 1992. 65 pgs. Excitotoxins ... The Taste That Kills - Russell L. Blaylock, M.D. Health Press, Santa Fe, N.M. 1994 - ISBN 0-929173-14-7 - $29.95

RADIO INTERVIEW WITH MARY STODDARD

ERNIE: Thanks for joining us tonight. We're glad you're with us. All across the state of Texas and parts beyond, it's good to have you here. Some important information and some information that will challenge, mystify and also make you want to maybe think about the things you eat and drink. Tonight I welcome Mary Stoddard to the microphone. Mary is here to talk about Aspartame. This is something that we've been hearing a little bit about in the media, but not a whole lot yet.

MARY: Yes, that's right. Based on the latest studies about connecting Aspartame with brain tumors and a higher incidence of brain tumors since the advent of Aspartame on the market, we have made the news quite a bit, all around the world, lately.

ERNIE: Now, when you talk about Aspartame, you're talking ... is this NutraSweet?

MARY: Aspartame is known as NutraSweet, Equal, Spoonfuls, DiabetiSweet, etc. It's known by a number of names around the world: Canderel in Europe. It's NatraSweet, I believe, in Brazil, and other places around the world it's called different things, but if you look for Aspartame on the label, you should be able to find it and be okay.

ERNIE: This is a chemical substitute for sugar. We find this in diet drinks, and Sweet and Low type products, things that take sugar out of the diet and put Aspartame in.

MARY: Right, the only thing that doesn't have it would be Sweet & Low. However is is combined with saccharin in some products, such as TAB, for example, the diet soft drink.

ERNIE: Well, why is this something to worry about? What is Aspartame all about?

MARY: Because, first of all, the tests were falsified to get it approved and get it on the market in the first place. The tests were submitted ... the lab animals in those tests had seizures. They had brain tumors. They had pancreatic tumors. They had mammary tumors, and they had uterine tumors. But, all this was covered up and erased when the tests were submitted.

ERNIE: Why?

MARY: Because it wouldn't have been approved.

ERNIE: Right.

MARY: And, it was approved as a food additive, not a drug. It was discovered as a drug in the 60's by a scientist who licked his fingers, said it tasted sweet, so let's make it a sweetener instead of a drug for peptic ulcers. It was first approved in 1974, but the approval was rescinded because of the brain tumor issue. That issue remains a very valid one today.

ERNIE: I remember back when this first came out, that ... I'm speaking from a very vague memory here ... but, there was a lot of furor about it. That it causes cancer, etc., and people didn't use it very much for awhile.

MARY: Yes.

ERNIE: What ever became of that?

MARY: Well, what became of it is a major marketing campaign was put into effect. Billions of dollars were spent on PR and Marketing, and it's been very effective. I mean, they're very good at that. Not a great products, but they're good at marketing their product.

ERNIE: Why is Aspartame bad? What does it do? What are the qualities of it ... the compounds?

MARY: Okay. First of all, it's a synthetic compound. It's two amino acids: Phenylalanine 50% which lowers the seizure threshold in some individuals, and the head of Brain Science at MIT said that it causes seizures and can cause brain tumors. Aspartic Acid is 40% of the molecule and according to Dr. John Olney, the world expert on Aspartic Acid, who just held the News Conference in Washington, November the 18th, in connection with Aspartame and brain tumors, said that it caused lesions in the brains of lab animals. What's more, it changed the DNA ... which means that it will affect future generations. It skipped a generation and went on to the third generation in the lab animal experiments ... producing morbidly obese and sexually dysfunctional lab animals.

ERNIE: So, this is something that people ... I'm sure there are people out there who drink diet drinks every day trying to lose weight, who are listening to this thinking: Well, maybe one or two reactions -- I've heard this before. I drink 'em. I don't have any problems. Or, this is the first time they've heard this and there's: Wait a second, what is this? They wouldn't put something that's so deadly on the market.

MARY: Well, they actually would. We compare this to the cigarette issue because it's a very close parallel. How many cigarettes does it take to cause lung cancer or a stroke, or a heart attack? How many diet drinks do you have to consume to get a brain tumor? How many spoonfuls of Equal do you have to take to have a pancreatic tumor or liver damage? The answer is: We don't know exactly what amount because it does not show up in short term testing. It's the long term effect. I got into this in the first place because of children and the effect it is having on children. I saw the effects in my youngest, who began to have migraines when she started drinking this Kool Aid flavored drink (Crystal Light) that came in sample packets in the mail to us. She developed chest pains and heart attack-like symptoms ... which I took her to a Heart Specialist for. Finally, she was carried in from a school field trip, after having had a grand mal seizure.

ERNIE: Now, what's that?

MARY: That is the worst kind of seizure. You lose consciousness, you fall to the ground in a fetal position and you're just out of it. That is the worst kind of seizure. There are many kinds of seizures that people can experience from Aspartame and from other causes as well, but the grand mal is the top of the line as far as danger goes. And so, when I discovered the one thing she was having was causing all these problems twelve years ago, I got her off of it and she's been just fine. Very healthy and seizure-free and no problem with that in the interim.

ERNIE: How did you know to trace it back to those things?

MARY: Well, it tasted funny to me. I was used to saccharin. I used the artificial sweetener, saccharin which has been around for a hundred years and no deaths reported ... only six complaints about saccharin had been reported to the FDA as of a couple of years ago, versus thousands and tens of thousands of complaints reported to the FDA about Aspartame. In fact, it's the most complained about additive in history. Aspartame has the most complaints on record. And, yet, the FDA refuses to do anything. I work with pilots. I have established a pilot's hotline in regard to this because an F-16 pilot asked me to do so when we were both in Washington testifying at the Senate Hearings. Working with pilots is an amazing thing. They lose their jobs. They lose, in some cases: their marriages, their homes, their families ... everything. And, in some cases ... their lives. I just finished filming a 60 Minutes segment for Australian TV for their 60 Minutes show. In it I had a pilot who was interviewed because he had a grand mal seizure in the cockpit in flight on a commuter airline in Alaska. This made national headlines about three years ago. Since he stopped using the artificially sweetened, ah, I think he was using Equal in his coffee and some drinks as well, he's been seizure-free. And, so he's been interviewed by the TV crew because it's such an astonishing story. Dozens of pilots have lost their medical certification to fly and one FAA Medical Examiner said, 'The FDA has its foot caught in a bucket, and it can't get it out.' And, so they don't know what to do. So, we're going to try to help them.

ERNIE: Well, now ... some statistical information on this: You have millions of people drinking these every day, but you're not getting reports of these types of things.

MARY: Well, you're just not getting reports of these types of things because, as I said to the doctors three weeks ago, when I was the first non-MD to lecture at Southwest Medical School in their Continuing Medical Education Series: You are going to find that these things mimic other syndromes such as MS (which is very difficult to diagnose); Fibromyalgia, which was never heard of before the advent of Aspartame and has become epidemic; Chronic Fatigue Syndrome ... when I called the Chronic Fatigue Hotline in 1987, they said to me Chronic Fatigue symptoms can be changed by changing your diet. I said, well, what does that mean? They said, do this, this and this .. and eliminate artificial sweeteners. Then, I said: Oh, you mean saccharin and Aspartame? They said: No, saccharin's okay. So, they knew back then that it caused Chronic Fatigue Syndrome. We also have more cases of brain tumors (10% more); Lupus; Manic Depression: Lou Gehrig's Disease; Attention Deficit Disorder in children, which Aspartame is capable of causing (hyperactivity in kids). A University of North Texas Professor came down with Graves Disease. She was checked into the hospital. Her doctor said: We must now irradiate your thyroid, young lady. And, she said, No, I don't think so. She checked herself out and went to a Nutritionist. He took her off Aspartame, put her on a healthy diet and she cured her Graves Disease.

ERNIE: I've heard this before. I have two friends who are Nutritionists. They have both told me the same thing about the diet drinks. They said: Don't drink them, because when they get hot, for example, the compounds that they break down into ... could you give us a little detail on that?

MARY: Right. They're (Phenylalanine and Aspartic Acid) are held in chemical bond by Methanol. Aspartame's 10% Methanol by weight. But, Methanol breaks down further into Formic Acid (the venom in ant stings), Formaldehyde (embalming fluid) and Diketopiperazine, the brain tumor agent ... the thing that kept it off the market, remember, back in 1974, when it was first approved by the FDA. The DKP kept it off the market because it causes brain tumors and the National Soft Drink Association complained bitterly about having to put Aspartame in soft drinks. They didn't want it. They didn't want the brain tumor issue associated with their product. And, you know it's a funny thing ... Monsanto is the parent company now of NutraSweet and Aspartame. Just a couple of weeks ago, they split their company in half. They split the Food part, which is the part that produces Aspartame, away from the Agricultural and other products part. And, when people say: Why did they do that? One reason, I think is because there are going to be lawsuits. I can't stop people from bringing suit against the company. I don't encourage it ever. But, I can't stop it on the other hand, and they know this is coming. They've hired big law firms. But, they falsified their tests to begin with.

ERNIE: Is that provable?

MARY: Yes. A U.S. Prosecutor ... and, this is all in our book, "Deadly Deception" ... there's a timeline and a history of Aspartame and the approval process, showing that Samuel Skinner, the U.S. Prosecutor, recused himself at the last minute. He was prosecuting the Pharmaceutical Company (G.D. Searle) for illegal acts. For falsifying their test results and turning in the tests tumor-free. And, not showing that some of the lab animals actually died and on paper, they were shown to be alive. We call it the Case of the Resurrected Rats. You know, these things really occurred, and they are criminal acts. And, so, they were being prosecuted and at the last minute, Samuel Skinner, the U.S. Prosecutor, went over to the Pharmaceutical Law Firm side and went to work for them (Sidley & Austin). He ended up in the White House as Bush's Chief of Staff, Samuel Skinner. His wife continued to work for Sidley & Austin, the NutraSweet law firm, while her husband, Skinner was in the White House. A former Monsanto attorney is now on the U.S. Supreme Court. Judge Clarence Thomas is a former Monsanto attorney. So, they have their Gate Keepers. They have people in high places. The company hired Donald Rumsfeld as its President. Now, Donald Rumsfeld was Chief of Defense in the Ford Administration, and has been very high up in many offices in many administrations. Now, why was he hired as head of a pharmaceutical company? It was political. This was gotten on the market by political and PR means, and has nothing to do with Science.

ERNIE: We're talking to Mary Stoddard tonight about Aspartame and I have to say that I have the information in front of me and I can't vouch for its accuracy or inaccuracy. I'm merely presenting a point of view, and if you want to present another side, I want you to do that. Or, if you agree or you have had incidents that you think are related to Aspartame, I'd like you to join the program. We have lines open for you on Texas U.S.A. Take the time, join us at 800-765-1080 tonight. This hour it's about your health. Let's go ahead and take some calls. First up in Glen Heights Texas on a car phone: Barbara. What's on your mind?

BARBARA: I'd like to know what other food should I look for with Aspartame, other than the cold drinks and the sweeteners?

MARY: Yes, that's a very good question, because it is in things that you wouldn't even believe. We were in Washington doing the taping recently and they said: Mary, go through the super market and fill a basket full of Aspartame sweetened products. Then, they said: Oh, wait a second, you'd better grab some other stuff too 'cause you won't fill a basket. I said: I'll bet I can. I came up with things like bottled water with Aspartame in it. There are flavored bottled waters that have Aspartame. I came up with, of course, children's vitamins, children's kool aid and Crystal Light, and fruit flavored drinks, juice drinks ... I had Alka Seltzer Plus, a lot of the Tylenol medications have it, Fiber One cereal and a lot of the fiber cereals have it. In fact, a lot of people call me. You know, we have a consumer hotline for the Aspartame Consumer Safety Network, and they'll say: Mary, I got off those diet drinks and I'm still feeling really lousy. Those headaches just won't go away. And, I say: What are you eating and drinking?Well, I cut out diet soft drinks with Aspartame, and I'm drinking TAB now with saccharine. I said, Go to the label. It has Aspartame, too. You just have to read labels, Barbara. Very, very carefully. It's in things you would never imagine ... like cold remedies, you know, Alka Seltzer Plus, and things like that. I think it's even in some lipsticks as well.

ERNIE: Anything, I guess, with a sweet flavor to it?

MARY: Yes, it can be. It's even in things for infants. Oh, it's even in Metamucil. A Pediatrician the other day prescribed Metamucil for an infant that had a little constipation. He said: Be sure to get the orange kind, because it tastes sweet. It's flavored. And, of course, it had Aspartame in it.

ERNIE: Yeah, it's odd with you think of where Aspartame is that we worry so much about four calories, five calories, ten calories, you find Aspartame in a Rolaids or a Tums type of product. You think ... for goodness sakes, are you counting every little bitty calorie? That makes no sense that you have to put dietary things in something that has four or five calories.

MARY: That's right. You know, what's happened is that we've become paranoid about a little bit of sugar or sucrose, and we've run right into the waiting jaws of the artificial stuff. We've done the same thing with the fat. It's laudable to get the fat foods out of your diet, but watch out when they talk about Simpless and that other fake fat, Olestra.

ERNIE: Olestra. What a nightmare!

MARY: Oh, it's just scary. People had rather die than eat sugar or fat. And, in some cases, that's the lesser of the two evils ... the real thing.

ERNIE: Ruth in Midland. Welcome to Texas U.S.A. for Mary Stoddard.

RUTH: My sister has been using Aspartame for quite some time now. She has developed some behaviors that are not characteristic of her. She's very irritable. She'll bite your head off. She's depressed. She developed real bad heart trouble, I don't know if that has anything to do with it or not.

MARY: It could. A lot of the pilots tell us that they stay away from diet drinks because it spikes the EKG. But, the psychological effects are probably the most insidious of all. It causes suicidal depression. That's a given. Anybody knows that Methanol (wood alcohol) can cause depression. It's a depressant. But, it also affects the brain in some very strange ways. It depletes or blocks production of Serotonin, which is the thing we all need for our moods to be level. The thing we need for our sleep patterns to be normal. And, in women, it regulates the menstrual cycle. Well, when Serotonin is blocked, then people can go into rages. Out of control. If these people were on steroids - anabolic steroids - you know people would say: Oh, yeah, that's a side effect of that. Well, they don't realize Aspartame can have similar effects. In fact, I knew a young man who wrote a book called, I Plead Insanity. He actually did plead insanity. He shot at three squad cars full of officers because he was hallucinating. He was heavily into the diet drinks. He drank a lot of them to get to that point, but he was literally committed to a mental institution because of his heavy consumption, and his predisposition to that sort of thing, but I think he never would have been driven over the edge into it (committing criminal acts) if something ain't messed with his brain. Serotonin is very interesting. Three Marines were released from the Marine Corps because they were said to be too aggressive. Now, how aggressive do you have to be to be kicked out of the Marine Corps! I thought the Marines were supposed to be. But, they tested these guys. They had low levels of Serotonin. I'm telling you. Serotonin is very important. When you deplete or block that production, you're looking for all kinds of bizarre - and, I do mean bizarre - psychological effects.

ERNIE: Is Serotonin something you buy artificially? I was just wondering if Serotonin is one of those new miracle things you can buy at the Health Food Stores.

MARY: No, Melatonin is somewhat akin to Serotonin, but Prozac, for example, is a stimulant of Serotonin. Now, why do all these people need to be on Prozac? It's because they have a blockage of Serotonin levels. And, so a lot of the things that we're doing today and tests that are being conducted on people medically are not even necessary. What I asked that group of doctors that I lectured to recently, is to think of this and use this in your history-taking. Ask about Aspartame consumption. It may be that this patient doesn't need an MRI or CAT SCAN or PET SCAN.

ERNIE: Right.

MARY: Get the patient off Aspartame (because it clouds the diagnosis) for a period of four to six weeks and then start to test. There may literally be something wrong. But, you'll never know as long as Aspartame is a part of the picture, because physiologically and psychologically, it's gonna mess you up sooner or later.

ERNIE: Jennifer in Irving, welcome to Texas U.S.A. for Mary.

JENNIFER: My OB/GYN told me that Aspartame is perfectly safe. It's a natural substance, or it copies a natural substance that sweetens cow's milk.

MARY: Oh, dear.

JENNIFER: Why would he tell me that?

MARY: I think you should change OB/GYNs. When I went to mine - it's interesting - I had a life threatening blood disorder develop in 1985 when I started going to Weight Watchers and using heavily, using diet drinks and the Weight Watcher's products. I went to my OB/GYN for a couple of things I couldn't figure out and he said ... Well, I said, could it be the NutraSweet and the new diet drinks and the things I'm eating and drinking? He said: Oh, no. What else do you eat and drink? I said: Well, this, this and this and cheese. He then went into a rampage over cheese. It was pure fat and women were killing themselves eating cheese. He just totally dismissed the thing that was really killing me literally. And, that's the Aspartame. So, he didn't know. I don't really blame him because he didn't know. My doctor of fifteen years didn't know. (My General Practitioner.) I still go to him. I think he's a great doctor. He tried. He even went to the Medical School and brought back one study and said: Mary, it looks like you have to drink gallons of this stuff (Aspartame) to have a seizure even. And, you've never even had a seizure. It's just the muscle spasms and joint pain and muscle cramps that I was having and other things associated with it. But, it was very severe and major. Finally, I went to the Medical School and a by-product of my spending hours, and days, and weeks, and years in the the Medical School Library book stacks is our 200 page report, Deadly Deception - The Story of Aspartame.

ERNIE: You're with Texas U.S.A. Ernie Brown is my name. Our guest, Mary Stoddard. We're talking about Aspartame. Let me go to caller Mary in Fort Worth. Welcome to the program.

CALLER M.: I drink diet drinks. I'd like to know if there are any that do not have Aspartame. And, what about Frosted Shredded Wheat, too?

MARY: Frosted Shredded Wheat as far as I know does not have it. The fiber cereals: Fiber One and maybe some other new ones, Sun Flakes has it and Sun Flakes is a little bit hard to find. But, about diet soft drinks: What you need to do if you are really serious about your quality of life (and, I think this is a quantity of life issue as well as quality of life) but, let's say it's just the quality of life issue. If you're serious about it, I would like to see you get off these things for four to six weeks and instead of diet soft drinks, if you've got to have something fizzy, get yourself some Club Soda and put a little bit of fruit juice in it. Try the bottled water.

ERNIE: Not diet fruit juice!

MARY: Oh, no, no, no, no, no. The real. Listen, I'm for real food. I'm for whole food, not unnatural. Not artificial things. And so, squeeze an orange in a glass of Club Soda or something and have that if you want a fizzy drink. I know you can't buy it in a soft drink machine, but they do have iced teas and juices and things that you can buy that would be a lot healthier than the soft drinks. And you know, I was telling Ernie during the break, I don't drink diet or regular soft drinks on a daily basis. And, when I do have one ... it's the real thing. And, I know it's a real treat. It just explodes in your mouth and the flavor is just wonderful. When people mindlessly drink six, eight, twelve drinks a day, whether they are diet or regular, they do it without even thinking and they're wasting all treat money. They are doing something that's not good for them. Not nutritious. And, I think that if we treated ourselves more and have them less often that would be something that would change our lives and we'd save so much money.

ERNIE: Let's go to Carrollton. Jay, welcome to Texas U.S.A. for Mary.

JAY: Hi Ernie. My daughter, Katrina, when we were living in Indianapolis, she was three years old and we had been giving her Flintstones vitamins and some other products that had NutraSweet in them, and we found her comatose and not breathing in bed one morning. And, so we got her to the hospital and about two hours later, they didn't know whether she was going to make it or not, because they didn't know what was wrong with her. After about three months of hospitalization, they never could really tell us what was wrong with her. Even after a battery of different types tests. For the longest time, we couldn't figure it out. She is semi-retarded because of it and since then, right after she got out of the hospital, my wife ... not knowing what the problem was, started to give her Flintstone vitamins again, thinking we were doing the right thing. She started having some of the same symptoms that she had had before she got ill. We immediately took a look at the bottle, and there was Aspartame in it. So, my wife called the company to find out more about it, and they said: Oh, no, don't worry about it. It's safe. You can feed it to them all day long. What we found out later, it was the Aspartame, and that my daughter was poisoned. My point is: if you're feeding your children anything with Aspartame in it, get them off of it ... because you're killing them. I mean literally, you're killing your children and taking away a chance to live a healthy life.

MARY: You're destroying their brains ... neurologically. That is such a powerful story. Just imagine being a parent in a case like that. Knowing now what caused it and having people not believe you when you say, Aspartame caused my child's problems.

ERNIE: Tell me the connection between Gulf War Syndrome that's getting a lot of attention these days.

MARY: Well, Aspartame breaks down into these neurotoxins. That means nerve poisons. Breakdown products of Aspartame.

ERNIE: Is there a certain amount of heat?

MARY: Anything above 85 degrees Fahrenheit. Now, think about it. Thousands of cases of diet drinks, according to Business Week and Mother Jones magazine, and a lot of other publications, were shipped free of charge - it was a PR campaign for the manufacturers ... to the desert. In 85 degrees heat it begins to break down into Methanol, Formic Acid, Formaldehyde, Diketopiperazine, the brain tumor agent. So, that after a number of days or weeks, there's no Aspartame left. I want to ask your listeners ... have you ever had a diet soft drink that didn't taste sweet? What you were drinking was the breakdown products. You weren't even drinking the sweetener. There was no Aspartame left. It was broken down, and I laughingly tell people - I had Gulf War Syndrome in 1985. I had all the symptoms: depression, chronic fatigue, skin lesions. All kinds of bizarre things were happening. Getting off of it got me well. But, I just wonder how many of our Military have been affected by this and we're covering that up as well. I do believe it is a factor. It may not be the only factor and cause -- because they did have some pretty exotic shots and vaccinations and stuff, too. But, I believe it's being covered up. I think that is the cause of a lot of their problems and the cause of the wives' problems. In our book, Deadly Deception, we have a whole section on children and one of the things is that it causes birth defects and we've got research studies that it caused birth defects in the lab animals. I have a newsletter from the Association of Birth Defect Children, the organization of note in birth defect studies, showing that it causes birth defects in children. It causes all kinds of things to happen. I believe it could be implicated in Gulf War Syndrome. I wish they would take a serious look at it. I sent it (the info) to Ross Perot, we faxed the Pentagon, the White House and to date no one has taken a real serious look at that.

ERNIE: Jackie in Grand Prairie, you are on Texas U.S.A. with Mary

JACKIE: Hi Mary. I just caught the tail end of your show here and I have a question. How much Aspartame consumed by a person affects them? Is it immediately if you had a diet drink?

MARY: Not everyone is affected immediately. It took me a period of months before I started. Mine started with a knee joint problem and progressed into severe muscle and joint pain ... like Fibromyalgia. Mine was medically diagnosed as Eosinophiliamyalgia Syndrome - which is a life threatening blood disorder. But, some children can chew one stick of chewing gum, Jackie, and go into seizure. That's been medically documented. Others can go for years and seemingly be alright just as smokers can go for years and not come down with lung cancer.

JACKE: So, it can affect people differently?

MARY: Oh, absolutely. And, it even affects the same person differently each time it's used, because if you think about how the breakdown products react, these products can be broken down to a different degree each time you have it. That's because they're not kept a a constant temperature. You might store them in your trunk or your garage, or they're in a warehouse. They're not always fresh and perfectly kept in storage.

JACKIE: That was my concern. I drank diet soft drinks for a number of years. Not on a daily basis, but maybe on a weekly basis, and I do have a hypothyroid condition. I was wondering if it had any effect on that?

MARY:It does affect the thyroid. It affects the thyroid, pituitary, the hypothalamus and the pineal gland.

ERNIE: Now, let's go to Betty in Fort Worth.

BETTY: My husband and I are both diabetics in our early sixties. I've always been very careful about the diabetic cooking and everything. I've used the NutraSweet and the Sugar Twin. Is there any sugar substitute that is safe?

MARY: Saccharin is one that we don't have a problem with. Other sweeteners, such as honey, 100% pure maple syrup, Turbinado Sugar, not the refined, but the unrefined sugars are not going to harm you. I'll bet diabetics can do their own finger stick test. When your blood sugar levels are well within normal range, test your levels and then drink two or three diet sodas one right after the other, preferably room temperature. Then, test yourself an hour later. I guarantee your blood sugar levels are going to be out of control. Off the charts. This (Aspartame) is not allowing diabetics to keep their blood sugar levels within control.

BETTY: Now, you mentioned honey and what kind of sugar?

MARY: Turbinado Sugar, which is the unrefined sugar. You can buy it in the Health Food Stores. You can buy Stevia, which is an herbal sweetener. A lot of people like that. It's very beneficial and it is approved now by the FDA for general use. So, there are a lot of other sweeteners. I'd use just about anything, before I'd use Aspartame.

ERNIE: Let's see if we can take one more call. Steve in Euless, you're on Texas U.S.A.

STEVE: Thanks. Mary, could you give that number again?

MARY: Yes. 1-800-969-6050. If you want that report, it's the Deadly Deception and our free information is on our web site. Just look up Mary Stoddard on the internet, or go to and you'll see we've got wonderful stuff on brain tumors and flying and Aspartame and the pilot issue. If you are a pilot, that's a must.

ERNIE: Are you a pilot, Steve?

STEVE: Yes. And, my wife's an R.D. (Registered Dietitian) also. Are you an R.D., Mary?

MARY: No, I'm not.

STEVE: I used to drink a ton of that stuff, and she slowly weaned me off of it.

MARY: Oh, good for her. She may have saved your life. Anyway, you're a lucky guy, and I'm glad she did that. You know more of us need to tell other people.

ERNIE: Thank you. When I told people about what I had learned from my nutritionist friends about it, they just, with a wave of their hand, they dismissed me. You don't know what you're talking about. It doesn't bother me. I feel fine, etc., etc.,etc.

MARY: Same thing you hear from smokers. I'm not going to get lung cancer. It's denial. I want people to get the report. It's not what I said. I haven't written it. I have edited and compiled it. It's from peer-reviewed Medical and Science Journals for a $25 donation. They can call right now and leave their names and phone numbers and they will be called back tomorrow during office hours. It's 1-800-969-6050. Call it today.

ERNIE: Al right, thank you. Mary Stoddard is her name. Mary, we'll have you back when we have more time to spend with you about this. There are a lot of issues we didn't get a chance to cover. It's good to see you, though.

MARY: Thanks, Ernie. I've loved it.

KRLD RADIO (1080 AM) DALLAS & TEXAS STATE NETWORK TRANSCRIPT: TEXAS U.S.A. TUESDAY, FEBRUARY 18, 1997 8:00 PM to 9:00 PM HOST: ERNIE BROWN GUEST: MARY NASH STODDARD, FOUNDER ACSN, DALLAS TX

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Aspartame Ingestion Causes Formaldehyde Accumulation

Aspartame Ingestion Causes Formaldehyde Accumulation in the Body
Excerpt from:

Trocho, C., et al., 1998. "Formaldehyde Derived From Dietary Aspartame Vinds to Tissue Components in vivo," Life Sciences, Vol. 63, No. 5, pp. 337+, 1998


"These are indeed extremely high levels for adducts of formaldehyde, a substance responsible for chronic deleterious effects that has also been considered carcinogenic.
....
"It is concluded that aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts."


"It was a very interesting paper, that demonstrates that formaldehyde formation from aspartame ingestion is very common and does indeed accumulate within the cell, reacting with cellular proteins (mostly enzymes) and DNA (both mitochondrial and nuclear). The fact that it accumulates with each dose, indicates grave consequences among those who consume diet drinks and foodstuffs on a daily basis." (Neuroscientist Russell Blaylock, MD)

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Aspartame and MSG Cause Painful Fibromyalgia Symptoms

Aspartame and MSG Cause Painful Fibromyalgia Symptoms
Ann Pharmacother 2001 Jun;35(6):702-6
Relief of fibromyalgia symptoms following discontinuation of dietary excitotoxins.
Smith JD, Terpening CM, Schmidt SO, Gums JG. Malcolm Randall Veterans Affairs Medical Center, Gainesville, FL, USA.

BACKGROUND: Fibromyalgia is a common rheumatologic disorder that is often difficult to treat effectively. CASE SUMMARY: Four patients diagnosed with fibromyalgia syndrome for two to 17 years are described. All had undergone multiple treatment modalities with limited success. All had complete, or nearly complete, resolution of their symptoms within months after eliminating monosodium glutamate (MSG) or MSG plus aspartame from their diet. All patients were women with multiple comorbidities prior to elimination of MSG. All have had recurrence of symptoms whenever MSG is ingested. DISCUSSION: Excitotoxins are molecules, such as MSG and aspartate, that act as excitatory neurotransmitters, and can lead to neurotoxicity when used in excess. We propose that these four patients may represent a subset of fibromyalgia syndrome that is induced or exacerbated by excitotoxins or, alternatively, may comprise an excitotoxin syndrome that is similar to fibromyalgia. We suggest that identification of similar patients and research with larger numbers of patients must be performed before definitive conclusions can be made. CONCLUSIONS: The elimination of MSG and other excitotoxins from the diets of patients with fibromyalgia offers a benign treatment option that has the potential for dramatic results in a subset of patients. PMID: 11408989

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Aspartame and Brain Tumors

Aspartame and Brain Tumors
A published study in Sweden that looked at various possible causes of brain tumors (e.g., cell phones, aspartame) found a link between use of diet drinks and certain types of large brain tumors in middle-aged and elderly population groups.

http://www.medscape.com/MedGenMed/braintumors

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Aspartame and Lymphomas / Leukemias

Aspartame and Lymphomas / Leukemias
A long-term study linking aspartame ingestion to lymphomas and leukemias in animals. The full study can be read at:

http://www.ramazzini.it/fondazione/docs/AspartameGEO2005.pdf.

Neurosurgeon Russell Blaylock M.D. commented: "The new study released in the European Journal of Oncology by Morando Soffritti and co-workers should terrify mothers and all those consuming aspartame sweetened products. This was a carefully done study which clearly demonstrated a statistically significant increase in several types of lymphomas and leukemias in rats. Both of these malignancies have increased significantly in this country since the widespread use of aspartame.

"This study confirmed the previous study by Dr. Trocho and co-workers, which also found the formaldehyde breakdown product of aspartame to be damaging to cellular DNA and that this damage was accumulative. The type of damage was a duplicate of that associated with cancers. Along with this most recent study, this means that drinking a single diet cola sweetened with aspartame every day could increase one's risk of developing a lymphoma or leukemia.

"They also found an increased incidence of malignant brain tumors, even though it was not statistically significant. This does not mean there is no association to brain tumors, since only the animals exposed to aspartame developed the tumors. With children and pregnant women drinking the largest amount of diet colas, this puts their children at the greatest risk of developing one of these horrible diseases. Their study found that even low doses of aspartame could cause these malignancies; yet, the higher the dose, the more cancers that were seen."

A followup study was published in Environmental Health Perspectives showing that there was a significant increase in cancer of the kidney and peripheral nerves. The full published study can be found in PDF format:

http://ehp.niehs.nih.gov/members/2005/8711/8711.pdf.

Ubercoach
 
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And For You Body Builders And Weight Class Athletes

ASPARTAME

A study conducted at the University of Texas Health Sciences Center reported a "41% increase in risk of being overweight for every can or bottle of diet soft drink a person consumes each day." The findings come from eight years of collecting data by Sharon P. Fowler, MPH and colleagues. The results of the study was reported at the 65th Annual Scientific Sessions of the American Diabetes Association in San Diet on June 10-14, 2005 (Abstract 1058-P). While this study, by itself, does not prove that aspartame causes weight gain, it adds to the evidence seen in independent research. For example, a study conducted by Dr. H.J. Roberts found that 5% of subjects reporting symptoms from aspartame also reported a "paridoxic weight gain." (Reactions Attributed to Aspartame-Containing Products: 551 Cases," Journal of Applied Nutrition, Volume 40, page 85-94). Lavin found that females with eating restraint had a higher Calorie intake subsequent to aspartame intake as opposed to sugar or water intake. (Lavin, J.H., S.J. French, N.W. Read, 1997. "The Effect of Sucrose- and Aspartame-Sweetened Drinks on Energy Intake, Hunger and Food Choice of Female, Moderately Restrained Eaters," International Journal of Obesity, Volume 21, pages 37-42, 1997.)

Ubercoach
 
What The Hell, One More Fun Aspartame Study

Aspartame and Combined Toxicity from Formaldehyde & Excitotoxins
A study published in Toxicology (2005 Jun 1; 210(2-3): 235-45. "Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species.") by Saito and colleagues demonstrates that formaldehyde is much more toxic to cells when free radical levels are increased. As has been demonstrated by Trocho, et al. in 1998, aspartame ingestion leads to the significant exposure to and accumulation of formaldehyde adducts in the organs and tissues. In addition, 40% of aspartame breaks down into an excitotoxic amino acid. As Neuroscientist Russell Blaylock points out, "Excitotoxins destroy neurons partly by stimulating the generation of large numbers of free radicals."

Ubercoach
 
Read Some Research Done In This Century...

Claim: The artificial sweetener aspartame has been proved responsible for an epidemic of cancer, brain tumors, and multiple sclerosis.

Status: False.

http://www.snopes.com/medical/toxins/aspartame.asp

At the risk of being accused of employing argumentum ad novitatem, the only valid research quoted was an MIT study done in '98.
Many more recent research invaidates that study. If you've read all these posts you've already read some.

Ubercoach
 
First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats. Environ Health Perspect. 2006 March; 114(3): 379???385.

Full paper here

Morando Soffritti, Fiorella Belpoggi, Davide Degli Esposti, Luca Lambertini, Eva Tibaldi, and Anna Rigano. Cesare Maltoni Cancer Research Center, European Ramazzini Foundation of Oncology and Environmental Sciences, Bologna, Italy

Our study shows that APM is a multi-potential carcinogenic compound whose carcinogenic effects are evident even at a daily dose of 20 mg/kg bw, much less than the current ADI for humans in Europe (40 mg/kg bw) and in the United States (50 mg/kg bw).

The results of carcinogenicity bioassays in rodents are consistent predictors of human cancer risks (Huff 1999; Rall 1995; Tomatis et al. 1989). The results of our study therefore call for an urgent reexamination of the present guidelines on the use and consumption of APM. The decision to use experimental data to protect public health is important because the time span of widespread APM use is still too brief to have produced solid epidemiologic data. Moreover, it is unlikely that sufficient epidemiologic data will be available in the near future, given the difficulty of finding a control group that has not been exposed to this widely diffused compound.

==================Related Citation=============

Sour Finding on Popular Sweetener: Increased Cancer Incidence Associated with Low-Dose Aspartame Intake. M. Nathaniel Mead. Environ Health Perspect. 2006 March; 114(3): A176.

More than 20 years have elapsed since aspartame was approved by regulatory agencies as an artificial sweetener. But scientists draw conclusions on carcinogenicity based on the evidence available at the time, and new research out of the European Ramazzini Foundation of Oncology and Environmental Sciences bolsters recent calls for reconsideration of regulations governing aspartame???s widespread use in order to better protect public health, particularly that of children [EHP 114:379???385; Soffritti et al.].

The researchers added aspartame to the standard diet of Sprague-Dawley rats, using dosages designed to simulate a wide range of human intakes. Each rat was observed from 8 weeks of age until death. This is in contrast with earlier studies that typically sacrificed animals between 104 and 110 weeks of age, corresponding to about two-thirds of a rat???s lifespan (in humans, approximately 80% of cancer diagnoses are made in the last third of life, after age 55). Deceased animals were examined for microscopic changes in various organs and tissues, enabling a comprehensive assessment of aspartame???s carcinogenic potential. A total of 1,800 rodents were included, far more than in previous studies.

Aspartame-fed females showed significant evidence of lymphomas/leukemias and of carcinomas of the renal pelvis and ureter. The effect on the renal pelvis was much more evident when carcinomas were combined with atypical preneoplastic lesions. The researchers also observed an insignificant increase in incidence of malignant schwannomas of the peripheral nerves in males, as well as hyperplasia of the olfactory epithelium in males and females. Lesions of the kidney and olfactory epithelium are extremely rare in this strain of rats and therefore merit special attention.

The carcinogenic effects were evident at daily doses as low as 400 parts per million, equivalent to an assumed daily human intake of 20 milligrams per kilogram body weight (mg/kg). This dosage is much less than the acceptable daily intake for humans, with current limits set at 50 mg/kg in the United States and 40 mg/kg in Europe. Surveys of aspartame intake in the United States and Europe from 1984 to 1992 showed that consumers typically consumed 2???3 mg/kg daily, with small children and women of child-bearing age consuming slightly more, at 2???5 mg/kg daily.

The public health implications of these findings may be substantial, since aspartame is used in about 6,000 products, and more than 200 million people regularly consume aspartame through foods, beverages, drugs (such as chewable vitamins), and hygiene products (such as toothpaste). Because the study did not take into account in utero and perinatal exposures, the authors point to this as a salient direction for future research, given that children and pregnant and breastfeeding women are among the major consumers of aspartame.

=======================================
Beyond these findings, and others posted here, the bottom line:

Aspartyl-phenylalanine-1-methyl ester binds to and either activates or inhibits glutaminergic or GABAnergic receptors, (respectively) throughout the body.

An increasing number of children and young adults are diagnosed with inborn glutamate pathway metabolic disorders.

These disorders are genetic, in the sense that they are induced by parental imprinting - changes in genes during germ cell (egg and sperm) development that affects offspring, either silencing or causing genetic changes in gene expression products (proteins that function in various biochemical pathways in liver, brain and other tissues).

The parental imprinting of these genes are most likely induced by low inhibitory and excess excitatory chemistry in parents. Why is this probable? Because the primary supergene expression control system balances on the in situ concentration of GABA.

Its that fucking simple.

So you have whole cohorts of genes that are silences or their activation and expression changed, resulting in:

autism
inborn metabolic dieases resulting in ectomorphy and endomorphy
chronic autocrine system dysfunction (various syndromes)
immune system disorders and autoimmune diseases of skin, thyroid, pancreas.
degenerative nerve disorders (Parkinsons, MS, CFS, ALS, etc)

and interestingly enough...

a prevalence towards gastrointestinal disease, now endemic in the adult population in the West.

Aspartame negatively affects the excitatory status in these imprinted and GABA and glutathione impaired (and gene silenced), individuals.

It is not a cause, but in each of these individuals, with their enhanced permeability of gut cell walls, there is increased absorption and co-sensitivity towards various microtoxins, in food, water, and produced as byproducts in gut itself, that contribute to the onset and persistance of many (if not most) common chronic diseases.

Co-attendant, is the lack of physical exercise, the prevelance towards accidental infection with pathogens and abuse of antibiotics in medicine and agriculture, a diet lacking in gut health promoting fiber and antioxidant rich foods - one that promotes excessive induction of insulin and LDL liver lipids.

Therefore, it is not a cause, but an additive agent that promotes what has become an epidemic of chronic diseases of modern civilization.

The evidence is massively overwhelming to support this conclusion. Western medicine, overly cautious and dependent upon direct evidence of negative effects when exerting control over various chemicals used as food and drug additives, is not likely to act on this connection, because it is contributory, but not directly causative, to chronic disease.

Not so for cancer...in which the leakage of nitrosamines and other carcinogenic agents into inflammed and ineffect tight cell junctions in gut mucosal membranes, seeps past normally impermeable cell barriers, and, in the absence of normally locally synthesized reducing equivalents that inactivate these carcinogens, co-promotes the rapid differentiation and turnover of cells.

This is hyperplasia, the progenitor condition to carcinogenesis.

Thus, we have not one, but many pathways indirectly negatively effected by the presence of aspartame, when consumed in low concentrations.

It is present in more than 20,000 food and vitamin / supplements.

Caveat emptor, baby.
 
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