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I was actually thinking of asking this for a couple weeks now, just never got around to it.
Because I train in my basement, I basically do it in socks. I figure there is plenty positive to come from this in terms of stability, use of muscles you might not use in shoes. Is there any negative though?
I honestly do NOT see any negative that could come from it. I mean, anatomically speaking, we as human were designed to not have shoes on our feet 24/7. We have basically "weakened" our feet by using overly cushioned, MC-type bricks. The one thing that a "barefooter" has to worry about is the horrible road conditions with debris, broken glass, etc.
It could be looked at in the same light as weight lifting. If the muscles are not used, eventually they become weak and atrophy. Our feet are made up of numerous muscles, tendons and nerves. The only thing I would recommend is start out SLOW. You are basically shocking muscles that are not used to being worked extensively.
I don't know how many of you run on your heels but it's far better for your joints and muscles to run on the ball of your foot. I run like that anyways. I dont understand why anyone would run heel to toe. So much slamming and you lose momentum. When you run on the ball of your feet you cushion the landing and allow more spring in your step.