Well one lowers estro, while the other inhibits testosterones conversation to estrogen. That said, if you’re showing signs of gyno and on cycle. You should run the adex , off cycle nolva it’s not too bad but if your gyno symptoms are very bad. Than go both just remember, estro isn’t a bad thing if it’s not causing noticeable gyno. If you kill all the estro, then you’re asking for joint issues. Hope this helps