ISAGENIX - Cleansing and Fat-Burning System

[chefbrian]

Xenbiotic contaminants and dietary effect on fatty liver syndrome

I suppose this is a good a place as any to ask this question! Don't know if you've run across a company called Isagenix, but if you do a search on the net, seems everybody is selling the stuff -a MLM company. Their main claim to fame is the following:

The basis of the Isagenix "diet" is cleanse the body and the weight will literally melt off. The body has a tendency to accumulate and retain fat longer when it is loaded with toxins The more chemicals and toxins, the more fat the body manufactures. Your body holds onto fat longer if it's loaded with chemicals and toxins.

Sounds like a lot of BS to me. At least it goes against the limited amount of physiology I've learned. Can someone tell me if fat indeed retain toxins as claimed? Is there any basis to their claim that it is possible to "scrub" the fat stored in the fat cells and remove the toxins stored there? And if you remove these toxins, the body sheds the fat? I figure there must some basis for these claims - they just can't be making all of this up. Any thoughts? I am in no way associated with the company! Only looking for insight. Thank you!

Moderators note
Edited this post to remove suspicious links to de-spam it, because there is a lesson to be learned in this pseudo question.

 

[Trouble]

I have no wish to validate this companies claims to liver cleansing, which often does more harm than good.

However, there is a grain in truth in their statements.

Various drugs and unatural (xenobiotic) compounds have been correlated to liver lipid biochemistry changes under the influence of diet. Xenobiotic metabolism (detox by three processes - Cytochrome P450 activation, glucuronidation and glutathione-conjugation) is known to be altered by diet. In turn, diet has been shown play a role in liver lipid regulation.

Lets say you take a drug, and it binds to the natural gene regulators, called nuclear receptors. There are nuclear receptors that are known to specifically bind xenobiotic steroid like compounds. In high doses, these same compounds nonspecifically (like a parasite) bind to other nuclear receptors that regulate cholesterol and fatty acid metabolism in liver. In turn, these nonspecific activation actions then cause lipids to accumulate in liver - the so called non alcoholic fatty liver syndrome.

Once you have those extra liver fats in place, they become a solvent layer for the accumulation of more xenobiotics from diet and absorbed from the environment that prefer to exist in these oily phases (what we call phase partitioning bahavior). They bioaccumulate, and can cause malignancies if they interact with DNA replication processes through those drug metabolism processes mentioned above.

I in no way endorse or recommend these liver cleanings bullshit treatments. Like I said, they can cause more problems than they fix, and they blatantly ignore the causes, so that you are suckered in periodically using these cleanses - which may dislodge and cause the xenobiotics to migrate elsewhere in the body (fatty contaminant redistribution).

I find it humorous that you post this advanced and complex question here. Ninety nine percent of forum "experts" don't know beans about xenobiotic contaminant metabolism and even fewer know shit about nuclear receptor action. That puts you in the tenths of a percent range for getting a semi correct guess.

As good a place as any? Hah!

 

[chefbrian]

Huh? I'm in 1/10 of 1% for getting a semi correct guess? I wasn't guessing anything - only quoting from the company page. I never figured it was that an advanced and complex question. As I said, I am in no way, shape or form associated with the company I mentioned. Just that I'm getting tired of people giving me this line about detoxifying and want am understanding of what's going on. So thanks for the input. Never heard of those little "xenobiotic" buggers and it seems too complicated to read about.

 

[Trouble]

Nope, you didn't guess anything correctly, but you did have four attributions to a company that could be mistaken as spam. I gave you the benefit of the doubt and removed those attributions, save the name name cited once, which is all we need to prevent its use as unsolicited advertising. I also gave you the benefit of the doubt, and answered your question. Certain contaminants start the liver to accumulate fat, and that traps and accumulates more toxins - that part of the company claims seems valid, but its doubtful the company or the vast majorty of the public understand why. And why it happens and what happens when you use these so called cleanses, are the reason I provided you with an an answer.

 

[chefbrian]

Right. Fair enough. And I appreciate you taking the time to give me an in depth answer. I would assume though that a liver cleanse would have almost negligible impact on a person's total body weight or over all bf %age. Seems what the company is suggesting is that their product does a total body body flush - not just the liver. Somehow this stuff is suppose to get into the fat cells, rinse out the toxins, then the fat dissolves and flows out. That's what accounts for the claimed 10 lbs a week and more weight loss. (They say it's fat.) Yeah, I know, I can see you sitting there shaking your head! That's what the reps say though. I know it's malarky, but dropped in here to ask anyhow!

 

[Trouble]

For one thing, you can't do a massive fat cell dump, its just going to be re-stored someplace else in the body.

Next item, you don't want the associated toxins hitting the liver and kidneys in load that they can't handle - if ANYTHING is going to further fuck up muscle, thryoid, adrenal, kidney, liver, gut, brain and pancreas function, its these suckers - the fatty acids and fat soluble contaminants - that are going to create cellular havoc by binding to all these nuclear gene regulators.

Last item, if there was a mechanism that would do a fat flush, don't you think it would be more popular by now? You can't get glucose metabolism turned off and fat metabolism turned on by just ingesting one of these whole body cleanse treatments, and you can't dump the contents of fat from SAT and VAT simply - there are sophisticated regulatory mechanisms in place that would be need to be overwhelmed in order to get fat cells to go into massive lipolytic metabolism..and again, if you don't burn it off, its going to be stored again unless it tied up and chauffered out of the body, and thats pretty damn tricky to do.

Nobody should do that massive of a body recomp (composition reconstitution) and expect the results to be permanent. More likely, you're seeing water loss associated with estrogen receptor fenagling on fat cells. The water will come back when the agents are flushed out of the body.