Making my own transport mix

[billyzane1]

I was thinking about adding M1T crushed up into my bottle of 4ad.

I know its a wacky idea, but I would think it has to work. The efficacy will be reduced of course, but one would think you would gain something out of it.

I did not like M1T orally at all. Too lethargic and the potential liver issues concern me.

Administration via transdermally would be much less of a risk.

Consider it my own S1+.

 

[Arnold]

that defeats the whole purpose of a methylated hormone, if you want a transdermal use 1-test, or better yet for that combo get S1+.

 

[XtremeFormula]

Originally posted by billyzane1

Administration via transdermally would be much less of a risk.

where in the world did you get this information?

 

[Twin Peak]

That makes no sense.

You shouldn't be playing with methylated hormones.

 

[billyzane1]

where I got my info

It does not do the double pass through your liver when administered via your skin.

Is that info correct? I heard it here somewhere. I could be wrong.

And to the other guy, I am not "playing" around with prohormones. I did tons of research before experimenting with them, and just found that M1T is not for me.

Rather than pitching 6 bottles, I would rather try to make my own S1 if you will, and see how it goes. I can tell I am getting results and I am not getting nearly the sides and lethargy and POISONING that I was getting before.

AND I was only taking 5mg and felt like shit.

 

[Twin Peak]

Okey dokey.

 

[billyzane1]

You did not answer my question if you could be so kind..

 

[Twin Peak]

What was the question?

This?

It does not do the double pass through your liver when administered via your skin.

Is that info correct?

I am not trying to be a prick, but that doesn't even make sense. "Do a double pass" does not mean anything. My hunch is that you are try to say that something administered transdermally, as opposed to orally, will skip the first pass of the liver. Yes, that is true.

And do you know why that is beneficial?

For some compounds, the first pass of the liver causes a major degredation of the compound, thus reducing oral efficacy/bioavailability. 1-test, 4-diol and other prohormones have low oral bioavailability because of the first pass of the liver.

Vitamin C, for example, has excellent oral bioavailability (i.e. it is not effected by the liver) and so, if you were to stick it in a transdermal gel, it would be a waste of time.

Is it starting to click?

Now, we mentioned 1-test above -- low oral bioavailability due to the first pass, so it makes sense to stick it in a gel, avoid the first pass and increase efficacy over oral administration.

Take 1-test and methylate it. Why would you do that? Adding the methyl increases oral bioavailability to damn near 100%. Why? Because it interferes with the liver's ability to break down the compound and render it useless. This is what causes increases liver enzyme levels, and (arguably) liver stress.

So by methylating it you (1) increase oral efficicacy, and (2) increase the chance of liver stress.

By then sticking it in a transdermal, you decrease (2) but simultaneously take away (1).

So my question to you is, why on earth would you bother?

Don't like the sides of M1T? Stick to a different compound, like a transdermal 1-test.

Prohormones and "prosteroids" are hormones and steroids, and they are serious compounds.

Use of them, without previous knowledge of all of the above, is in my opinion tantamount to "playing with hormones", hence my comment above.

 

[plouffe]

Thanks for that bit of info.

 

[billyzane1]

Thanks man

 

[ZECH]

Great explaination...............Props!

Originally posted by Twin Peak
What was the question?

This?



I am not trying to be a prick, but that doesn't even make sense. "Do a double pass" does not mean anything. My hunch is that you are try to say that something administered transdermally, as opposed to orally, will skip the first pass of the liver. Yes, that is true.

And do you know why that is beneficial?

For some compounds, the first pass of the liver causes a major degredation of the compound, thus reducing oral efficacy/bioavailability. 1-test, 4-diol and other prohormones have low oral bioavailability because of the first pass of the liver.

Vitamin C, for example, has excellent oral bioavailability (i.e. it is not effected by the liver) and so, if you were to stick it in a transdermal gel, it would be a waste of time.

Is it starting to click?

Now, we mentioned 1-test above -- low oral bioavailability due to the first pass, so it makes sense to stick it in a gel, avoid the first pass and increase efficacy over oral administration.

Take 1-test and methylate it. Why would you do that? Adding the methyl increases oral bioavailability to damn near 100%. Why? Because it interferes with the liver's ability to break down the compound and render it useless. This is what causes increases liver enzyme levels, and (arguably) liver stress.

So by methylating it you (1) increase oral efficicacy, and (2) increase the chance of liver stress.

By then sticking it in a transdermal, you decrease (2) but simultaneously take away (1).

So my question to you is, why on earth would you bother?

Don't like the sides of M1T? Stick to a different compound, like a transdermal 1-test.

Prohormones and "prosteroids" are hormones and steroids, and they are serious compounds.

Use of them, without previous knowledge of all of the above, is in my opinion tantamount to "playing with hormones", hence my comment above.