What were they at what time interval?
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- Thread starter SloppyJ
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What were they at what time interval?
dollarbill
Registered
this, inquiring minds want to know
Definitely looks under dosed but there is GH in there.10ius at 6am
test at 9:30
subQ
6.4
exphys88
Registered
Use our protocol for a better comparison.
Are you talking about this?
The Protocol:
The Protocol:
- Inject 10 iu IM.
- Have your blood drawn 3-4 hours after injecting.
- Fasting is not necessary.
- No strenuous activity for at least 30 min prior to test.
exphys88
Registered
Yep, fasting or not fasting doesn't matter, so if you're fasting for other tests, it's fine. IM injections give higher readings and subq readings are a bit more inconsistent.
dollarbill
Registered
10ius at 6am
test at 9:30
subQ
6.4
what batch number are these?
10ius at 6am
test at 9:30
subQ
6.4
are these from the same source as the 33's?
dollarbill
Registered
thats same batch as sloppy.
BigBadBen
Registered
If that is the case why are these readings all over the place...the diff between subq and IM should not be that great.....very odd indeed.
that raises a couple of new questions...
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The difference between IM and Subq is significant. Likely by a factor of 2 times.
10iu subq should hit at least 15ng/mL and the same dose IM should hit 30ng/mL.
BigBadBen
Registered
Really...interesting...well Heavy I am heading over to my Dr office to pick up my Hyges results. I pinned subq rather than IM. I know you want IM as the standard so we will see how these come in.
Sounds good brother.
BigBadBen
Registered
![IMG_0334 [1024x768].JPG](/data/attachments/5/5535-a4d91d75263b3a0b7e857e723e863201.jpg?hash=pNkddSY7Og)
BigBadBen
Registered
Oh I am a nob, posted in the wrong thread...sorry SJ. Ben
When your dealing UG products, most of the time the Lot # doesnt mean anything. My guess is that these boxes and labels are made up ahead of time and used until they run out regardless of what 'lot' they came from. Its easier for labs to put a number on the label and print multiple sheets of the same numbers than to keep changing with each individual batch.
Thats my guess as to why your seeing varying numbers between products that have the same lot number. Its just a label.
Thats my guess as to why your seeing varying numbers between products that have the same lot number. Its just a label.
I have never heard that or seen that anywhere. That would make me feel alittle better if true since i did subq for my first test. Where did you get that info from?
Guys I confirmed that the batch numbers mean nothing on these novos and thanks. The supplier said they ship out bulk labels to their people like two times per year. So a wide range of batches will have the same labels. Makes you wonder.
Pharmacokinetics and pharmacodynamics of GH: dependence on route and dosage of administration
- Alexandra Keller,
- Zida Wu1,
- Juergen Kratzsch2,
- Eberhard Keller,
- Werner F Blum3,
- Astrid Kniess4,
- Rainer Preiss5,
- Jens Teichert5,
- Christian J Strasburger1 and
- Martin Bidlingmaier6
- Hospital for Children and Adolescents, University of Leipzig, Oststr. 21???25, D-04317 Leipzig, Germany, [SUP]1[/SUP]Division of Clinical Endocrinology, Department of Medicine, Charité University-Medicine, 10117 Berlin, Germany, [SUP]2[/SUP]Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 61350 Leipzig, Germany, [SUP]3[/SUP]Eli Lilly & Co., Bad Homburg, Germany and Children???s Hospital, University of Giessen, 01731 Giessen, Germany, [SUP]4[/SUP]Institute of Doping Analysis and Sports Biochemistry, 04107 Kreischa, Germany, [SUP]5[/SUP]Institute of Clinical Pharmacology, University of Leipzig, Leipzig, Germany and [SUP]6[/SUP]Department of Internal Medicine, Ludwig Maximillian University of Munich, 80336 Munich, Germany
- (Correspondence should be addressed to A Keller; Email: alexandra.keller@medizin.uni-leipzig.de)
Abstract
Objective: Pharmacokinetic and pharmacodynamic data after recombinant human GH (rhGH) administration in adults are scarce, but necessary to optimize replacement therapy and to detect doping. We examined pharmacokinetics, pharmacodynamics, and 20 kDa GH after injection of rhGH at different doses and routes of administration.
Design: Open-label crossover study with single boluses of rhGH.
Methods: Healthy trained subjects (10 males, 10 females) received bolus injections of rhGH on three occasions: 0.033 mg/kg s.c., 0.083 mg/kg s.c., and 0.033 mg/kg i.m. Concentrations of 22 and 20 kDa GH, IGF-I, and IGF-binding proteins (IGFBP)-3 were measured repeatedly before and up to 36 h after injection.
Results: Serum GH maximal concentration (C[SUB]max[/SUB]) and area under the time-concentration curve (AUC) were higher after i.m. than s.c. administration of 0.033 mg/kg (C[SUB]max[/SUB] 35.5 and 12.0 μ g/l; AUC 196.2 and 123.8). C[SUB]max[/SUB] and AUC were higher in males than in females (P < 0.01) and pharmacodynamic changes were more pronounced. IGFBP-3 concentrations showed no dose dependency. In response to rhGH administration, 20 kDa GH decreased in females and remained suppressed for 14???18 h (low dose) and 30 h (high dose). In males, 20 kDa GH was undetectable at baseline and throughout the study.
Conclusions: After rhGH administration, pharmacokinetic parameters are mainly influenced by route of administration, whereas pharmacodynamic variables and 20 kDa GH concentrations are determined mainly by gender. These differences need to be considered for therapeutic use and for detection of rhGH doping.
Damn all this HGH talk really makes me want to jump on board too! This section is amazing! Thanks to everyone who contributes, and thanks to IM for creating this...
suprfast
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Completely agree. Make me want to donate a few bucks to keep the testing going. Small thanks I guess.
I don't usually post here but just want to say the mods here are doing an amazing job of letting the truth come to light. Most boards (with sponsors) censor results in a big way. Don't take your mods for granted.
trainhard357
Registered
I think we also need to look at how the GH is being stored when it comes to potency. Not by just the end user but also the sponsor. Also is the GH being damaged in the shipping process? This can and will affect the GH. By how much is anybody's guess.
panteracfh
Registered
+1
I definitely think storage, handling, and just the whole process the gh goes through from the factory to finally getting in the customers hand plays a significant role in it's quality. To what extent seems to be unknown. For example the impact of one shipment taking 15 days to get to a remailer as opposed to 3 days is hard to say. Also other variables like higher temperatures and rough handling for random shipments.
Given that the batch numbers aren't really batch numbers, it's hard to have 100% quality control but just the fact that people are starting to test frequently and re-test the same brands is a huge step forward.
BFHammer
Registered
PM board is doing a lot of testing as well, maybe you guys should team up and save costs a bit.
Thanks for these tests guys!
It's got me thinking hard about research with these type products. Now that costs are coming down to reasonable levels.
Thanks for these tests guys!
It's got me thinking hard about research with these type products. Now that costs are coming down to reasonable levels.
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Yes, I visit with rAJJIN weekly about the thread over there. It has been very interesting to see them reach similar conclusions as us.
