The primary triggers for muscle hypertrophy are mechanical load/tension, density, and total time under tension. Load and tension is simply the amount of weight lifted. The more you lift, the greater the level of intramuscular tension. The greater the intramuscular tension, the greater the amount of protein degradation and resultant amino acid uptake by your muscles.
On the topic of maximizing intramuscular tension, two other things that work to increase intramuscular tension are explosive concentric contractions and slow eccentric contractions. In a practical sense, this simply means that increasing the speed of the overcoming portion of your rep and decreasing the speed of the yielding portion of your rep will result in increased intramuscular tension.
Total time under tension is associated with volume. Note, that this doesn???t necessarily mean the time under tension of each set, but the cumulative effect of all sets over the course of a workout. Doing more sets increases the total time a given muscle is under tension. As well, manipulating the tempo of a rep also affects time under tension (i.e. longer eccentrics). While loading/tension and density are the key triggers for maximum muscle growth, sufficient ??? but not excessive ??? volume helps manifest these structural adaptations. This tends to be an important factor in the overall amount of muscle growth achieved as it results in greater levels of protein degradation.
In the end, the keys to maximum muscle growth are high levels of muscular fatigue, intramuscular tension, and motor unit activation.
Manipulate the eccentric speed, but 9 times out of 10, the concentric should be fast.