February 14, 2010, 01:14 PM
http://www.adistem.com
Adistem are the guys doing the Adipose Stem Cell injections for hairloss and this is the new cream version.
TB4-7™ Peptide from AdiStem
TB4-7™ Peptide applied topically or given systemically promotes angiogenesis and wound healing, cardioprotective and immuno-potentiating effects, hair growth and thickness, hair coloration change (from grey back to its original darker colour) and has very potent anti-aging, anti-wrinkle and anti-scarring properties. Trials amongst body builders have also shown increased muscle growth and strength together with improved energy levels and other benefits.
TB4-7 (patent pending) is a synthetic peptide analogue of the active region of Thymosin B4.
Thymosin β4, a ubiquitous 4.9-kDa polypeptide of 43 amino acids length originally isolated in 1981 from the thymus gland, is a potent mediator of cell migration and differentiation1-6.
It is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells13 and circulating levels in the serum reduce with age. TB4 binds to actin, blocks actin polymerization, and is the actin-sequestering molecule in eukaryotic cells14-20).
It was identified as a gene that was up-regulated four- to six fold during early endothelial cell tube (blood vessel) formation and found to promote angiogenesis. It is present in wound fluid7, and when applied topically or given systemically, it promotes angiogenesis and wound healing3).
Thymus extracts (which contain small amounts of Thymosin beta 4), have been used successfully both orally and by injection in patients since the 1960’s in Europe (see Biofactor). Derived from our autologous adipose-derived stem cell clinical trials and research, we have uncovered that one of the main factors that the stem cells secrete to induce repair and an anti-aging effect were various peptides belonging to the TB4 family. TB4-7 (patent pending) was the most potent fragment from this family of secreted peptides that we discovered.
Wound-Healing
TB4 elicits cell migration through a specific interaction with actin in the cell cytoskeleton8,9. Recently, it was demonstrated that a central small amino acid long actin binding domain has both angiogenic and wound healing activity while other domains of the protein are inactive10.
In angiogenesis and in wound healing, TB4 acts by accelerating the migration of endothelial cells and keratinocytes and increasing the production of extracellular matrix-degrading enzymes4,9. TB4 has also shown to increase corneal epithelial cell migration in vitro and in vivo, with activity in the nanogram range1. Thymosin beta 4 is found in high concentrations in platelets22. TB4 also has anti-inflammatory activity1,11 and more recently has also been shown to stimulate epidermal stem cell differentiation12.
Together, these data show that TB4 is a potent, naturally occurring wound repair factor. It is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration, does not bind to the extracellular matrix, and has a very low molecular weight, and thus can diffuse relatively long distances through tissues4,21.
Hair Growth
It has also been demonstrated that TB4 promotes hair growth in various rat and mice models including a transgenic TB4 overexpressing mouse24. The mechanism by which TB4 acts to promote hair growth is by its stimulatory effects on follicle stem cell growth, migration, differentiation, and protease production.
Anti-Aging Properties
Applied topically on the skin (as a spray or cream), TB4-7b has very potent anti-aging, anti-wrinkle, anti-scarring and wound healing properties. No adverse or unwanted effects have been observed in case studies and in a phase I/II clinical trial involving 30 patients. Applied topically on the scalp, promotion of hair thickness, change in coloration (from grey back to its original darker colour), and hair growth have also been clearly observed.
Large Clinical Trial About to Be Initiated
When injected into patients it promotes activation of circulating and various organ stem cells in a safe manner, leading to a very potent anti-aging effect. Benefits have so far been observed in patients with a variety of degenerative diseases, such as heart disease, neuromuscular disease, diabetes and emphysema, to name a few. A large clinical trial under FDA regulations is about to be initiated on the efficacy of TB4-7 in patients with Type II diabetes, Duchenes Muscular dystrophy and emphysema.
As has been shown in cardiac tissue, TB4-7 promotes the activation of cardiac muscle and endothelial progenitor cells, and their survival, and decreases muscle apoptosis25. Similarly in the cornea, TB4 promotes cell migration and wound healing, has anti-inflammatory properties, and suppresses apoptosis26. Another group’s results indicate that TB4 also promotes the survival and neurite outgrowth of cultured spinal cord neurons27. We have observed similar promotive effects of TB4 on the survival and stimulation of skeletal muscle progenitors and myocytes.
Already Used By Body Builders
Human trial candidates have noticed the following in an ongoing trial in body builders where they inject 10mg of TB4-7 twice weekly for four weeks:
•Increased muscle girth.
•Faster recovery time (wear and tear) from training.
•Increased muscular endurance.
•Increased muscular strength.
•Decreased musculoskeletal pain.
•Improved hand-eye coordination.
•Increased energy levels.
•Improved mood (decreased anxiety).
•Improved sleeping patterns.
•Improved concentration span and short-term memory.
•Improved hair growth.
AdiStem TB4-7™ Peptide is an injectable formulation of TB4. A similar formulation has just completed Phase I clinical trials and has been shown to be safe and well-tolerated. The product candidate has been developed to address medical indications where subcutaneous administration is warranted. AdiStem Ltd. is currently planning a Phase I/II clinical trial to evaluate AdiStem TB4-7™ in type II diabetic patients although other indications such as motorneurons disease, emphysema, and Duchene’s muscular dystrophy have been identified as potential targets.
Available in a Cream for Hair Growth through ActiStem Ltd.
AdiStem TB4-7™ Peptide is now available in a cream for hair growth. You can purchase or view more information on our distributor’s website, ActiStem.com.
About AdiStem Ltd.
Aside from autologous adipose-derived stem cell therapy, AdiStem Ltd. is focused on the discovery and development of novel stem cell derived peptides to accelerate tissue and organ repair. Currently, AdiStem Ltd. is developing a product candidate, TB4-7, for Type II diabetes. AdiStem Ltd. is also developing other product candidates for use on other diseases. These product candidates are based on TB4, a synthetic derivative copy of the 43-amino acid, naturally occurring peptide. AdiStem Ltd. holds and has applied for over 6 world-wide patents and patent applications related to novel peptides to date.
CONTACT US
Telephone: +632 856 5100
Fax: +632 856 9206
Email: info@AdiStem.com
You can also reach us by completing and returning the Inquiry Form
http://www.actistem.com
http://www.adistem.com
Adistem are the guys doing the Adipose Stem Cell injections for hairloss and this is the new cream version.
TB4-7™ Peptide from AdiStem
TB4-7™ Peptide applied topically or given systemically promotes angiogenesis and wound healing, cardioprotective and immuno-potentiating effects, hair growth and thickness, hair coloration change (from grey back to its original darker colour) and has very potent anti-aging, anti-wrinkle and anti-scarring properties. Trials amongst body builders have also shown increased muscle growth and strength together with improved energy levels and other benefits.
TB4-7 (patent pending) is a synthetic peptide analogue of the active region of Thymosin B4.
Thymosin β4, a ubiquitous 4.9-kDa polypeptide of 43 amino acids length originally isolated in 1981 from the thymus gland, is a potent mediator of cell migration and differentiation1-6.
It is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells13 and circulating levels in the serum reduce with age. TB4 binds to actin, blocks actin polymerization, and is the actin-sequestering molecule in eukaryotic cells14-20).
It was identified as a gene that was up-regulated four- to six fold during early endothelial cell tube (blood vessel) formation and found to promote angiogenesis. It is present in wound fluid7, and when applied topically or given systemically, it promotes angiogenesis and wound healing3).
Thymus extracts (which contain small amounts of Thymosin beta 4), have been used successfully both orally and by injection in patients since the 1960’s in Europe (see Biofactor). Derived from our autologous adipose-derived stem cell clinical trials and research, we have uncovered that one of the main factors that the stem cells secrete to induce repair and an anti-aging effect were various peptides belonging to the TB4 family. TB4-7 (patent pending) was the most potent fragment from this family of secreted peptides that we discovered.
Wound-Healing
TB4 elicits cell migration through a specific interaction with actin in the cell cytoskeleton8,9. Recently, it was demonstrated that a central small amino acid long actin binding domain has both angiogenic and wound healing activity while other domains of the protein are inactive10.
In angiogenesis and in wound healing, TB4 acts by accelerating the migration of endothelial cells and keratinocytes and increasing the production of extracellular matrix-degrading enzymes4,9. TB4 has also shown to increase corneal epithelial cell migration in vitro and in vivo, with activity in the nanogram range1. Thymosin beta 4 is found in high concentrations in platelets22. TB4 also has anti-inflammatory activity1,11 and more recently has also been shown to stimulate epidermal stem cell differentiation12.
Together, these data show that TB4 is a potent, naturally occurring wound repair factor. It is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration, does not bind to the extracellular matrix, and has a very low molecular weight, and thus can diffuse relatively long distances through tissues4,21.
Hair Growth
It has also been demonstrated that TB4 promotes hair growth in various rat and mice models including a transgenic TB4 overexpressing mouse24. The mechanism by which TB4 acts to promote hair growth is by its stimulatory effects on follicle stem cell growth, migration, differentiation, and protease production.
Anti-Aging Properties
Applied topically on the skin (as a spray or cream), TB4-7b has very potent anti-aging, anti-wrinkle, anti-scarring and wound healing properties. No adverse or unwanted effects have been observed in case studies and in a phase I/II clinical trial involving 30 patients. Applied topically on the scalp, promotion of hair thickness, change in coloration (from grey back to its original darker colour), and hair growth have also been clearly observed.
Large Clinical Trial About to Be Initiated
When injected into patients it promotes activation of circulating and various organ stem cells in a safe manner, leading to a very potent anti-aging effect. Benefits have so far been observed in patients with a variety of degenerative diseases, such as heart disease, neuromuscular disease, diabetes and emphysema, to name a few. A large clinical trial under FDA regulations is about to be initiated on the efficacy of TB4-7 in patients with Type II diabetes, Duchenes Muscular dystrophy and emphysema.
As has been shown in cardiac tissue, TB4-7 promotes the activation of cardiac muscle and endothelial progenitor cells, and their survival, and decreases muscle apoptosis25. Similarly in the cornea, TB4 promotes cell migration and wound healing, has anti-inflammatory properties, and suppresses apoptosis26. Another group’s results indicate that TB4 also promotes the survival and neurite outgrowth of cultured spinal cord neurons27. We have observed similar promotive effects of TB4 on the survival and stimulation of skeletal muscle progenitors and myocytes.
Already Used By Body Builders
Human trial candidates have noticed the following in an ongoing trial in body builders where they inject 10mg of TB4-7 twice weekly for four weeks:
•Increased muscle girth.
•Faster recovery time (wear and tear) from training.
•Increased muscular endurance.
•Increased muscular strength.
•Decreased musculoskeletal pain.
•Improved hand-eye coordination.
•Increased energy levels.
•Improved mood (decreased anxiety).
•Improved sleeping patterns.
•Improved concentration span and short-term memory.
•Improved hair growth.
AdiStem TB4-7™ Peptide is an injectable formulation of TB4. A similar formulation has just completed Phase I clinical trials and has been shown to be safe and well-tolerated. The product candidate has been developed to address medical indications where subcutaneous administration is warranted. AdiStem Ltd. is currently planning a Phase I/II clinical trial to evaluate AdiStem TB4-7™ in type II diabetic patients although other indications such as motorneurons disease, emphysema, and Duchene’s muscular dystrophy have been identified as potential targets.
Available in a Cream for Hair Growth through ActiStem Ltd.
AdiStem TB4-7™ Peptide is now available in a cream for hair growth. You can purchase or view more information on our distributor’s website, ActiStem.com.
About AdiStem Ltd.
Aside from autologous adipose-derived stem cell therapy, AdiStem Ltd. is focused on the discovery and development of novel stem cell derived peptides to accelerate tissue and organ repair. Currently, AdiStem Ltd. is developing a product candidate, TB4-7, for Type II diabetes. AdiStem Ltd. is also developing other product candidates for use on other diseases. These product candidates are based on TB4, a synthetic derivative copy of the 43-amino acid, naturally occurring peptide. AdiStem Ltd. holds and has applied for over 6 world-wide patents and patent applications related to novel peptides to date.
CONTACT US
Telephone: +632 856 5100
Fax: +632 856 9206
Email: info@AdiStem.com
You can also reach us by completing and returning the Inquiry Form
http://www.actistem.com
Last edited:
