Real World Use
In addition to these specific studies, real world use of TU for hypogonadism provides some very telling data. Undecanoate requires 120-240mg/day for satisfactory replacement (36-39), which is about 5-10mg, delievered, per day. Taking the middle numbers of both, we get 4% bioavailability. It should also be noted (and this is obvious from the above numbers, which give a range of 2-8%), that the efficacy of TU has been shown to vary greatly in the real world as well as clinical settings.
So, as you can see, though we do get some improvement compared to the free steroid, it is very far from spectacular. Given 15% delivery for the base, and assuming the androgen is dissolved in oil and the consumer takes the product with a very fatty meal, we end up at around 18-20%, (but individuals would proabably vary from just 15% to as high as 25%) -- and if not, we don't go much beyond the 15% of the free steroid.
So, now that we have looked at the technology, let us turn to the individual products:
1-Test Ethylcarbonate Ester (Mag-10)
There is no research on this ester improving oral bioavailability and there is no Log P data. Patrick Arnold has tested it and found it to be extremely insoluble in oil, which if true, would indicate that the afore mentioned lymphatic absorption would not occur. They claim that it gets close to 100% absorption, but offer no supporting evidence whatsoever, and it goes completely against all scientific data in existence, and there is an enormous body of literature on the subject, thus terms such as "full of shit", "fraudulent claims", and "blatantly lying" come to mind, but those are ugly words, so I shall not speak them. This should get the same 15% bioavailability as the free base.
If that were not enough, Mag-10 contains only 4.2 grams of 4-AD and 1-Test, combined and counting the weight of the ester -- and the 4-AD is listed first, so it is the major compound. They are clearly hiding the amount of 1-test for a reason, and it isn't because it is some magical number that needs to be kept secret from competitors. Usinmg the 3.5 to 1 ratio in ONE+, that comes out to a mere 950 mg of 1-test and 3.25 grams of 4-AD. If we are generous and assume that it contains a 2 to 1 ratio, we get 1.4 grams of 1-test and 2.8 grams of 4-AD. If the good folks at Biotest want to divulge the actual numbers, we will be more than happy to amend this article. Oh yeah, and it carries a massive $99.99 price tag for a 2 week supply. discount $68.95
1-Test THP Ether Capsules (Sauce, T-100).
As we have shown, lymphatic absporptin with the THP ethers is very questionable, and it requires that the steroid be dissolved in oil and taken with a very fatty meal more maximal effect. The ether would increase lipophilicity to some extent over the base, so it should perform marginally better, in that it would tend to be solubized in the intestine more quickly. We will say 15-18%, depending on if it is taken with a fatty meal or not.
Sauce (Syntrax) contains 4.5 grams of 1-test per bottle and retails for $69.95 and discounts for $43.95
T-100 (S.A.N.) contains 4.7 grams of 1-test per bottle and retails for $79.95 and discounts for $49.99
1-Test THP Ethergels (1-T)
Again, the data suggests that lymphatic absorption is very questionabel. However, the early real world feedback certainly seems to show the ethergels to be superior to the base and ethers without oil -- again, this could be explained by quicker micellation in the small intestine. Let us estimate the ethergels at 18-20%, depending on if it is taken with a meal. And, with a bit more feedback, and/or a viable theory on an alternate mechanism of action for the ether, we could go as high as 25%
1-T (Molecular Nutrition) contain 1.8 grams of 1-test and retails for $64.99 and discounts for $39.99
While designing a better delivery system is pretty exciting to a scientist, for the consumer, it all comes down to cost effectiveness, so let's see how the products stack up. We will use a relative scale based on the amount of product delivered per unit price. We will use suggested retail -- a little math will allow you to convert the numbers based on what you actually pay for the product. We will set the value for the 1-test base (One-T) at 100 -- thus, a product that scores 150 gives you 50% more for your money. Because Mag-10 and ONE+ also contain 4-AD, we will set ONE+'s score equal to ONE and determine Mag-10 based on ONE+ (and we will give 2 scores for it based on our two assumtpions of amount of actives)
Products
Score
ONE (Avant Labs)
205
ONE+ (Avant Labs)
205
Sauce (Syntrax)
166
T-100 (S.A.N.)
152
One-T (Gaspari Nutrition)
100
1-T (Molecular Nutrition)
97
Mag-10 (Biotest)
24-48
Now, I may be wrong here as I`ve not used VPX but I believe
one bottle has only 1000mg of 1test in it.......
http://www.avantlabs.com/main.php