exphys88
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post up where you got the adex from too.
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post up where you got the adex from too.
Get some legit ancillaries from ResearchStop or ChemOneResearch.
tinyshrek
Registered
I love chemone still my fav site for research
exphys88
Registered
This isn't the first time I've heard complaints about CEM
Ok so I said fuck the bullshit and went with researchstop. Ordered the 60ml aromasin and 60ml arimidex and the metered dropper. I got overnight ups at 70.00. Man this was expensive. From what you guys said they are worth it. So im in 100%.
What dosages should I be taking when the shipment gets here on Tuesday?
Thanks fellas
I should have made sure prior but, the website is: researchstop.com, right?
What dosages should I be taking when the shipment gets here on Tuesday?
Thanks fellas
I should have made sure prior but, the website is: researchstop.com, right?
exphys88
Registered
It it were me, I'd take 25 mg every 12 hours until it comes down to normal.
They are top of the line brother. VERY good products.
ExemeSolut
Aromasin has a short half life in men so you need 25mg every 12 hours.
Adex has a much longer half life. 1mg ADEX ED is plenty.
I have a slight preference for Aromasin but either will work just fine.
Once you dial in legit Aromasin you likely won't use anything else my friend.
ResearchStop's products have worked very well for me. Their customer service is really good to. They don't normally ship to Canada but we worked something out
I never heard of them before and was just checking out the site. The prices are fucking sweet compared to most. I'm thinking I'll be trying these guys next for sure.
Thanks heavy and exphy. You guys are always enlightening me. Thanks my friends.
Could someone explain the suicidal effect aromasin has? Does it mean that is destroys itself and the enzyme at the end of its life?
Could someone explain the suicidal effect aromasin has? Does it mean that is destroys itself and the enzyme at the end of its life?
Aromasin
(Exemestane)
Aromasin is a steroidal aromatase inactivator used to lower circulating estrogen. It was developed to help fight breast cancer as estrogen plays a role in the growth of cancer cells. Aromasin binds irreversibly to the aromatase enzyme. This suppresses the conversion of androgens into estrogen. Circulating estrogen can be reduced by nearly 85% in women using Aromasin. A common misconception is that aromatase inhibition is similar in men than women. However in trials when males were administered 25mg of Aromasin daily, maximal estradiol suppression of 62 ± 14% was observed at 12 hours. The reason for the difference may be related to the the much higher testosterone concentrations in young males than in postmenopausal women and the shorter half-life of exemestane in males. The terminal half-life in males (8.9 h) was considerably shorter than the published value of 27 h in females. This may be a basis for more frequent administration in men (or women administering testosterone) that want maximal E2 supression.
Aromasin acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." In other words, Exemestane, by being structurally similar to the target of the enzymes, permanently binds to those enzymes, thereby preventing them from ever completing their task of converting androgens into estrogens. When we compare this mode of action against other AI’s the benefit becomes clear. Arimidex can unbind from the aromatase enzyme when you stop taking it but Aromasin will not. Therefore, there is less chance of estrogen rebound with Aromasin.
Aromasin can be employed during a steroid cycle when aromatizing compounds such as testosterone are administered in order to control estrogen from getting out of control. During the course of a typical steroid cycle estrogen can rise quite high. Estrogen has been measured as much as 7 times higher than normal in men on steroids. This is excessive and can potentially cause water retention, gynecomastia (the formation of female breast tissue), negatively effect libido or cause benign prostatic hyperplasia. Therefore in order to avoid these side effects estrogen must be controlled.
Aromasin not only lowers circulating estrogen and sex hormone binding globulin but it also increases free testosterone by a whopping 117%! Total testosterone increases about 60%. Check out the performance of Aromasin after just 10 days of treatment in males.
FIG. 1. Estrogen and androgen plasma levels after 10 d of daily exemestane (25 or 50 mg) in healthy young males (mean ± SD; n = 9–11). To convert to Systeme International units: estradiol, picomoles per liter (x3.671); estrone, picomoles per liter (x3.699); androstenedione, nanomoles per liter (*0.003492); and testosterone, nanomoles per liter (x0.03467).
Aromasin may be used during a steroid cycle with aromatizing compounds and during PCT to help keep the estrogen to testosterone balance in favor of testosterone. Out of all the medications to control estrogen, Aromasin seems to be the most well balanced. It raises testosterone similar to Arimidex and lowers estradiol about 10% better than arimidex in men and is likely to cause less estrogen rebound than Arimidex. Keep in mind that 50mg of Aromasin daily kept estradiol in the normal range for men so if you think using an aromatase inhibitor will crush estrogen too much this science supports the opposite. Additionally, plasma lipids and IGF-I concentrations in men were unaffected by Aromasin treatment. From the data I have read and my years of experience with this medication, 25mg of Aromasin every other day is a good starting point on moderate doses of testosterone. If testosterone doses are raised then 25mg daily may be needed to control estrogen. Since either high and low estrogen can cause side effects such as low libido only labs can determine the appropriate dose of Aromasin.
Reference
Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males
~heavyiron
(Exemestane)
Aromasin is a steroidal aromatase inactivator used to lower circulating estrogen. It was developed to help fight breast cancer as estrogen plays a role in the growth of cancer cells. Aromasin binds irreversibly to the aromatase enzyme. This suppresses the conversion of androgens into estrogen. Circulating estrogen can be reduced by nearly 85% in women using Aromasin. A common misconception is that aromatase inhibition is similar in men than women. However in trials when males were administered 25mg of Aromasin daily, maximal estradiol suppression of 62 ± 14% was observed at 12 hours. The reason for the difference may be related to the the much higher testosterone concentrations in young males than in postmenopausal women and the shorter half-life of exemestane in males. The terminal half-life in males (8.9 h) was considerably shorter than the published value of 27 h in females. This may be a basis for more frequent administration in men (or women administering testosterone) that want maximal E2 supression.
Aromasin acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." In other words, Exemestane, by being structurally similar to the target of the enzymes, permanently binds to those enzymes, thereby preventing them from ever completing their task of converting androgens into estrogens. When we compare this mode of action against other AI’s the benefit becomes clear. Arimidex can unbind from the aromatase enzyme when you stop taking it but Aromasin will not. Therefore, there is less chance of estrogen rebound with Aromasin.
Aromasin can be employed during a steroid cycle when aromatizing compounds such as testosterone are administered in order to control estrogen from getting out of control. During the course of a typical steroid cycle estrogen can rise quite high. Estrogen has been measured as much as 7 times higher than normal in men on steroids. This is excessive and can potentially cause water retention, gynecomastia (the formation of female breast tissue), negatively effect libido or cause benign prostatic hyperplasia. Therefore in order to avoid these side effects estrogen must be controlled.
Aromasin not only lowers circulating estrogen and sex hormone binding globulin but it also increases free testosterone by a whopping 117%! Total testosterone increases about 60%. Check out the performance of Aromasin after just 10 days of treatment in males.
FIG. 1. Estrogen and androgen plasma levels after 10 d of daily exemestane (25 or 50 mg) in healthy young males (mean ± SD; n = 9–11). To convert to Systeme International units: estradiol, picomoles per liter (x3.671); estrone, picomoles per liter (x3.699); androstenedione, nanomoles per liter (*0.003492); and testosterone, nanomoles per liter (x0.03467).
Aromasin may be used during a steroid cycle with aromatizing compounds and during PCT to help keep the estrogen to testosterone balance in favor of testosterone. Out of all the medications to control estrogen, Aromasin seems to be the most well balanced. It raises testosterone similar to Arimidex and lowers estradiol about 10% better than arimidex in men and is likely to cause less estrogen rebound than Arimidex. Keep in mind that 50mg of Aromasin daily kept estradiol in the normal range for men so if you think using an aromatase inhibitor will crush estrogen too much this science supports the opposite. Additionally, plasma lipids and IGF-I concentrations in men were unaffected by Aromasin treatment. From the data I have read and my years of experience with this medication, 25mg of Aromasin every other day is a good starting point on moderate doses of testosterone. If testosterone doses are raised then 25mg daily may be needed to control estrogen. Since either high and low estrogen can cause side effects such as low libido only labs can determine the appropriate dose of Aromasin.
Reference
Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males
~heavyiron
werd...spill the beans dog...
I'd say....EP...
Fuck. I have 2 vials of Clomiphene, 1 vial of anastrozole, 1vial of Exemestane and 1 vial of letrozole. All unopened from EP.
PappyMason
Registered
Cud they be extremely underdosed?
Evil Eagle
Registered
Last I knew it had been a while since they carried pde5 inhibitors.
Sent from my DROID RAZR using Tapatalk
Ok. So i am a little frustrated. I have some aromasin from cem on hand and so when I got my results back over the weekend I dropped the arimidex from cem and started up the aromasin @25mg twice a day. So I started that protocol yesterday. This morning I took another dose of 25mg @4am and just took my blood test this morning at 8am.
Is there any issues with taking the blood test this soon after changing protocols? How about the times I am taking the aromasin, any issues? 4am and blood test at 8am?
As always I will let everyone know the results.
I should be receiving my order from researchstop tomorrow morning. I will start the same protocol of aromasin as soon as I receive the package.
Could I then schedule another blood test for thursday?
I should be kosher right?
Thanks fellas
Is there any issues with taking the blood test this soon after changing protocols? How about the times I am taking the aromasin, any issues? 4am and blood test at 8am?
As always I will let everyone know the results.
I should be receiving my order from researchstop tomorrow morning. I will start the same protocol of aromasin as soon as I receive the package.
Could I then schedule another blood test for thursday?
I should be kosher right?
Thanks fellas
rage racing
Registered
I have been taking Manpowers Aromasin (12.5mg ED) for 2 weeks now. I get labs in about 6weeks to see where my test and estro levels are. I guess the labs will tell the truth. Hope his shit is GTG
You want mine? I would hook you up with my EP stuff except I think I would be doing you a misjustice even pretending that stuff would work for you. I think the only good thing about EP is the cool blue bottles they package their crap in. I was ready to throw them out but my old lady want the bottles cause she thinks they look cool.
I have clomid and tamox from CEM. Should I even use it? If it is under dosed/bunk that could fuck my whole PCT world up.
I dont think I want to risk it.
Darnit even more money down the drain.
I will have to pick up some pharma grade clomid. At least I have pharma grade nolva on hand.
This is definately not a poor man's sport...
I dont think I want to risk it.
Darnit even more money down the drain.
I will have to pick up some pharma grade clomid. At least I have pharma grade nolva on hand.
This is definately not a poor man's sport...
CEM Store
Registered
Acemon, check your PMs
Thanks,
CEM
Thanks,
CEM
Probably overkill but...I ordered from manpower as well. Aromasin, caber and clomid. I hope they are good. Well I think that put me at plan "a" covered by plan "b" and plan "c" just in case.
I hope this is the last time I have to scramble for AI's and peace of mind.
I will post my results
I hope this is the last time I have to scramble for AI's and peace of mind.
I will post my results
exphys88
Registered
I always keep multiple brands of AI's and serms on hand. Gyno is the worst thing I can think of. Well, maybe second to ED. I keep cialis and viagra on hand too.
Now he will buy bulk Cialis =)
Just to further complicate things, i'm currently running clomid from EP and it's definitely working. The mood swings and extreme emotional reactions to anything and everything are quite pronounced. That being said, I'll probably get blood tests in 2 weeks and repost in this topic.
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Bro..I had a few bottles of clen, exemestane, injectable l-carnitine and b12, tadalafil...all thrown out...
