Novotropin and Thanktropin

[vannesb]

Pharmacokinetics and pharmacodynamics of GH: dependence on route and dosage of administration

• Alexandra Keller,
• Zida Wu1,
• Juergen Kratzsch2,
• Eberhard Keller,
• Werner F Blum3,
• Astrid Kniess4,
• Rainer Preiss5,
• Jens Teichert5,
• Christian J Strasburger1 and
• Martin Bidlingmaier6

+ Author Affiliations

• Hospital for Children and Adolescents, University of Leipzig, Oststr. 21–25, D-04317 Leipzig, Germany, [SUP]1[/SUP]Division of Clinical Endocrinology, Department of Medicine, Charité University-Medicine, 10117 Berlin, Germany, [SUP]2[/SUP]Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 61350 Leipzig, Germany, [SUP]3[/SUP]Eli Lilly & Co., Bad Homburg, Germany and Children’s Hospital, University of Giessen, 01731 Giessen, Germany, [SUP]4[/SUP]Institute of Doping Analysis and Sports Biochemistry, 04107 Kreischa, Germany, [SUP]5[/SUP]Institute of Clinical Pharmacology, University of Leipzig, Leipzig, Germany and [SUP]6[/SUP]Department of Internal Medicine, Ludwig Maximillian University of Munich, 80336 Munich, Germany

• (Correspondence should be addressed to A Keller; Email: alexandra.keller@medizin.uni-leipzig.de)

Abstract

Objective: Pharmacokinetic and pharmacodynamic data after recombinant human GH (rhGH) administration in adults are scarce, but necessary to optimize replacement therapy and to detect doping. We examined pharmacokinetics, pharmacodynamics, and 20 kDa GH after injection of rhGH at different doses and routes of administration.
Design: Open-label crossover study with single boluses of rhGH.
Methods: Healthy trained subjects (10 males, 10 females) received bolus injections of rhGH on three occasions: 0.033 mg/kg s.c., 0.083 mg/kg s.c., and 0.033 mg/kg i.m. Concentrations of 22 and 20 kDa GH, IGF-I, and IGF-binding proteins (IGFBP)-3 were measured repeatedly before and up to 36 h after injection.
Results: Serum GH maximal concentration (C[SUB]max[/SUB]) and area under the time-concentration curve (AUC) were higher after i.m. than s.c. administration of 0.033 mg/kg (C[SUB]max[/SUB] 35.5 and 12.0 μ g/l; AUC 196.2 and 123.8). C[SUB]max[/SUB] and AUC were higher in males than in females (P < 0.01) and pharmacodynamic changes were more pronounced. IGFBP-3 concentrations showed no dose dependency. In response to rhGH administration, 20 kDa GH decreased in females and remained suppressed for 14–18 h (low dose) and 30 h (high dose). In males, 20 kDa GH was undetectable at baseline and throughout the study.
Conclusions: After rhGH administration, pharmacokinetic parameters are mainly influenced by route of administration, whereas pharmacodynamic variables and 20 kDa GH concentrations are determined mainly by gender. These differences need to be considered for therapeutic use and for detection of rhGH doping.

Great information bro!

 

[BFHammer]

Yes, I visit with rAJJIN weekly about the thread over there. It has been very interesting to see them reach similar conclusions as us.

Awesome. That eli lex tested was insane. I didn't see a comment on why that was so high.

 

[heavyiron]

Awesome. That eli lex tested was insane. I didn't see a comment on why that was so high.

It is way above anything I have ever seen. Maybe an error.

 

[murse24]

It is way above anything I have ever seen. Maybe an error.

yea herd it was a lab error ....

 

[canesfan]

I got the same batch of Thanks from a A+ A= "source" and this is my result. Im pissed! Now I did do it sub-q and drew 3.5 hours after. Maybe I need to redo and do IM but will a slin 1/2" needle in delt do it? Im switching over to HK's rips or a source tried and true. To many mixed reviews you dont know who the f*ck to use!

 

[panteracfh]

Tested novos, 29.6 . . . same batch as SloppyJ but as we know, batch numbers don't really mean anything. Pics to come.

 

[exphys88]

Would you mind starting your own thread w labs and pics please?

 

[petey2005]

These serums tests are going to be highly subjective, If you have a much higher mass than someone else, not to mention body compostion, the results are going to be different. I think there should be a sticky with Just relative information for each. Protocol - Test result - weight, body fat %, height, current supplements, etc- and then a pic of lab + label for verification. Its getting hard to keep up with all the different tests and with limited information idk what to think. Obviously we have a few that are consistantly above the rest but I'm about to set up a spreadsheet for this or something. lol

 

[exphys88]

We have a summary of results posted already.

 

[panteracfh]

Would you mind starting your own thread w labs and pics please?

Yep, will do this afternoon.

 

[heavyiron]

These serums tests are going to be highly subjective, If you have a much higher mass than someone else, not to mention body compostion, the results are going to be different. I think there should be a sticky with Just relative information for each. Protocol - Test result - weight, body fat %, height, current supplements, etc- and then a pic of lab + label for verification. Its getting hard to keep up with all the different tests and with limited information idk what to think. Obviously we have a few that are consistantly above the rest but I'm about to set up a spreadsheet for this or something. lol

Read the sticky brother

 

[petey2005]

We have a summary of results posted already.

Oh... Must have missed that I guess if the tests are coming back positive its not really necessary to give a weight either.

 

[petey2005]

I was really looking forward to practicing my spreadsheet skills. Lol

 

[mormussle]

my friend and I tested both Thanks 15.4 and Rips 20, the Thanks were 25% cheaper, so the cost difference was a wash, Both good in my opinion. I was hoping for higher results but everyone tests different. I have even had a good bro test 17 on rips, and others test in the 30"s on the same stuff. IDK But Rips , Thanks, or Novo's all seem to be a good gamble these days. I also think you are right about a lot of them being exactly the same product from the same factory in a lot of cases.

 

[danielnguyen73]

I'd wait for the lab results in print. How would you know your result if you dont have a copy?
They're junk, Ive tested them.