Trenbolone not for me

[heavyiron]

^^lol thanks for all the input.. after reading this i would like to try prami and see what happens..lmfao As i stated above, its really disappointing to me and hate writing it off.. we sill see. Ill keep all updated if i decide to try running it with prami..

Dose your Prami first thing AM or you will likely have sleep issues. The first time using Prami don't drive. It can really knock you out for a few hours but some guys it really energizes. This effect is dose dependent in studies.

As soon as you get out of bed use .25-0.3mg Prami. Before bed use 0.5mg-1mg Xanax. Stay positive and keep reminding yourself the Tren is the cause of your aggression.

No carbs the last meal of the night or you will be a furnace and sweat a ton.

Good luck brother.

 

[SloppyJ]

I've never tried prami but had only positive results with caber. No sides to speak of.

And stay away from Alldaychemist. They are fucking scammers.

 

[heavyiron]

Prami is ideal for this application because it has anti-depressant effects.

 

[heavyiron]

Prami reduces depression and allows more feelings of pleasure.


Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.

Lemke MR, Brecht HM, Koester J, Reichmann H.
Center of Psychiatry and Neurology, Rhine Clinic Bonn, Germany. mr.lemke@lvr.de

Depression affects approximately 45% of all patients with Parkinson's disease, reduces quality of live independent of motor symptoms and seems to be underrated and undertreated. Pramipexole shows D(3)- versus D(2)-receptor preference at cortico-frontal dopamine receptors and neurotrophic effects which seem to relate to its antidepressant and anti-anhedonic properties in Parkinson's disease and bipolar depression found in controlled studies. In the present study, effects of pramipexole were investigated under routine clinical conditions. Anhedonia was measured in patients with Parkinson's disease (n=657) using the self-rated Snaith-Hamilton-Pleasure-Scale (SHAPS-D), depression was assessed by the observer-rated Short-Parkinson's-Evaluation Scale (SPES). Anhedonia was present in 45.7% of all patients and in 79.7% of the depressed patients with Parkinson's disease. Mild depression was present in 47%, moderate to severe depression in 22% of the patients. At the end of the study period of 9 weeks on an average, the mean dosage of pramipexole was 1.0+/-0.6 mg/d (range 0.3 to 4.2). Frequency of depression (moderate to severe: 6.8%, mild: 37.6%) and anhedonia (25.5%) as well as motor deficits were significantly reduced during treatment with pramipexole. Drop-outs due to adverse events occurred in 3.5%. Future studies should investigate specificity of anti-anhedonic and antidepressive properties of pramipexole.

PMID: 16814808 [PubMed - indexed for MEDLINE]

 

[heavyiron]

Pramipexole in treatment-resistant depression: a 16-week naturalistic study.

Lattanzi L, Dell'Osso L, Cassano P, Pini S, Rucci P, Houck PR, Gemignani A, Battistini G, Bassi A, Abelli M, Cassano GB.
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Italy. paolo.cassano@psico.med.unipi.it

OBJECTIVE: To assess the antidepressant efficacy and tolerability of adjunctive pramipexole, a D2-D3 dopamine agonist, in patients with drug-resistant depression. METHODS: The study sample consisted of in-patients with major depressive episode, according to the DSM-IV, and drug resistance. Pramipexole was added to antidepressant treatment with TCA or SSRI, at increasing doses from 0.375 to 1.0 mg/day. Two independent response criteria were adopted: a > 50% reduction of the Montgomery-Asberg Depressive Rating Scale (MADRS) total score and a score of I or 2 on the Clinical Global Impression scale (CGI-1) at endpoint. Side-effects were assessed by the Dosage Record Treatment Emergent Symptom Scale (DOTES). RESULTS: Thirty-seven patients were enrolled. Of these. 16 had unipolar depression and 21 had bipolar depression. Six patients dropped out in the first week. Of the 31 patients included in the analyses. 19 completed the 16-week follow-up. Mean maximal dose of pramipexole was 0.95 mg/day. Mean scores on MADRS decreased from 33.3 +/- 8.4 at baseline to 13.9 +/- 11.5 at endpoint (p < 0.001) and the CGI-S decreased from 4.6 +/- 0.8 at baseline to 2.8 +/- 1.3 at endpoint (p < 0.001). At endpoint, 67.7% (21/31) of patients were responders on MADRS and 74.2% on CGI-I. Of the 37 patients enrolled, 10 discontinued pramipexole because of adverse events. CONCLUSIONS: These preliminary data suggest that pramipexole adjunction to antidepressant treatment may be effective and well tolerated in patients with resistant major depression.

PMID: 12479663 [PubMed - indexed for MEDLINE]

 

[heavyiron]

Am J Psychiatry 161:564-566, March 2004
© 2004 American Psychiatric Association
Brief Report


Preliminary Randomized, Double-Blind, Placebo-Controlled Trial of Pramipexole Added to Mood Stabilizers for Treatment-Resistant Bipolar Depression

Joseph F. Goldberg, M.D., Katherine E. Burdick, Ph.D., and Carrie J. Endick, C.S.W.

OBJECTIVE: Previous studies suggest that the dopamine agonist pramipexole may possess antidepressant properties. The authors conducted a preliminary randomized, placebo-controlled trial to determine the safety and antidepressant efficacy of pramipexole in treatment-resistant bipolar depression. METHOD: Twenty-two depressed outpatients with DSM-IV nonpsychotic bipolar disorder were randomly assigned to receive placebo or flexibly dosed pramipexole (mean maximum dose=1.7 mg/day, SD=1.3) added to existing mood stabilizers for 6 weeks. The primary outcome measure was response, defined as improvement in Hamilton Depression Rating Scale score of 50% or more over the baseline score; secondary analyses involved changes in Clinical Global Impression (CGI) severity scores. RESULTS: More patients given pramipexole (10 [83%] of 12) than patients given placebo (six [60%] of 10) completed the study. Eight (67%) of 12 patients taking pramipexole and two (20%) of 10 taking placebo had an improvement of at least 50% in their Hamilton depression scale scores. The mean percentage of improvement from baseline Hamilton depression scale scores was greater for patients taking pramipexole (48%) than for those taking placebo (21%). Mean improvements in CGI severity were also greater with pramipexole than placebo. No patients discontinued the study because of adverse events except for one patient who became hypomanic while taking pramipexole. CONCLUSIONS: Pramipexole was a safe and effective antidepressant among patients with bipolar depression. Larger randomized, controlled trials are needed to affirm these initial observations.

 

[heavyiron]

Antidepressant effects of pramipexole, a novel dopamine receptor agonist.

Maj J, Rogóz Z, Skuza G, Kołodziejczyk K.
Institute of Pharmacology, Polish Academy of Sciences, Kraków.

Pramipexole (2-amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochl oride), a new dopamine receptor agonist with preference for D3 compared to D2 and D4 receptors, was tested in rats in respect of its potential antidepressant activity. In the forced swimming test the drug under study, given three times in rats, reduced the immobility time. In the forced swimming test, joint treatment with antidepressants (imipramine, amitriptyline) and pramipexole evoked a more potent effect than any of the drugs given alone; however, the locomotor hyperactivity was weaker after joint administration. Citalopram and fluoxetine, inactive per se in the forced swimming tests, visibly enhanced the antidepressant-like effect of pramipexole but, on the other hand, they attenuated the locomotor hyperactivity evoked by the drug. Repeated treatment with pramipexole (0.3 or 1 mg/kg, twice daily for 14 days) increased the locomotor activity measured at 1 h after the last dose. Repeated administration of pramipexole (as above) potentiated the D-amphetamine- or quinpirole-induced locomotor hyperactivity. The obtained results indicate that, in the tests used, pramipexole evokes effects similar to those of typical antidepressants and, at the same time, enhances their activity (the forced swimming test in rats); therefore it may be regarded as a potential antidepressant drug.

PMID: 9295183 [PubMed - indexed for MEDLINE]

 

[FordFan]

Prami is strong shit. Be careful and start very low. Like i said above. I can only take .1ml per dose. Anymore and I get very sick.

With that said, i hope to be trying some caber very soon.

 

[heavyiron]

Prami is strong shit. Be careful and start very low. Like i said above. I can only take .1ml per dose. Anymore and I get very sick.

With that said, i hope to be trying some caber very soon.

1ml is a huge dose.

These days I only use 0.3-0.5mg. Today I used 0.3mg and it's plenty. Years ago I went way higher and it was not worth it IMHO.

 

[yerg]

Antidepressant effects of pramipexole, a novel dopamine receptor agonist.

Maj J, Rogóz Z, Skuza G, Kołodziejczyk K.
Institute of Pharmacology, Polish Academy of Sciences, Kraków.

Pramipexole (2-amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochl oride), a new dopamine receptor agonist with preference for D3 compared to D2 and D4 receptors, was tested in rats in respect of its potential antidepressant activity. In the forced swimming test the drug under study, given three times in rats, reduced the immobility time. In the forced swimming test, joint treatment with antidepressants (imipramine, amitriptyline) and pramipexole evoked a more potent effect than any of the drugs given alone; however, the locomotor hyperactivity was weaker after joint administration. Citalopram and fluoxetine, inactive per se in the forced swimming tests, visibly enhanced the antidepressant-like effect of pramipexole but, on the other hand, they attenuated the locomotor hyperactivity evoked by the drug. Repeated treatment with pramipexole (0.3 or 1 mg/kg, twice daily for 14 days) increased the locomotor activity measured at 1 h after the last dose. Repeated administration of pramipexole (as above) potentiated the D-amphetamine- or quinpirole-induced locomotor hyperactivity. The obtained results indicate that, in the tests used, pramipexole evokes effects similar to those of typical antidepressants and, at the same time, enhances their activity (the forced swimming test in rats); therefore it may be regarded as a potential antidepressant drug.
PMID: 9295183 [PubMed - indexed for MEDLINE] [/QUOTE

Citalopram 60mg a day

 

[heavyiron]

Neuroendocrine and side effect profile of pramipexole, a new dopamine receptor agonist, in humans.

Schilling JC, Adamus WS, Palluk R.

Human Pharmacology Centre, Boehringer Ingelheim KG, Germany.

The effects and tolerability of pramipexole, a new dopamine D2-receptor agonist, on prolactin, human growth hormone, thyrotropin, cortisol, and corticotropin levels were investigated in a randomized, double-blind, crossover study in 12 healthy volunteers. Single oral doses of 0.1, 0.2, and 0.3 mg pramipexole and placebo were studied over a period of 24 hours. Pramipexole decreased serum prolactin levels in a dose-dependent manner, with a maximum effect after 2 to 4 hours. Serum levels of human growth hormone were dose-dependently increased; however, this effect was only significant 2 hours after drug administration. Furthermore, a slight increase in serum cortisol levels and a slight decrease in serum thyrotropin levels was observed. Our findings show for the first time pharmacodynamic effects of pramipexole after single oral doses in healthy volunteers. The compound was well tolerated and showed an endocrine profile similar to other dopamine D2-agonists.

PMID: 1350237 [PubMed - indexed for MEDLINE]

 

[FordFan]

1ml is a huge dose.

These days I only use 0.3-0.5mg. Today I used 0.3mg and it's plenty. Years ago I went way higher and it was not worth it IMHO.

It was a typo. I think ive got it fixed. I can only handle .1ml

 

[yerg]

Good info Heavy! Im not gonna pretend like i understand every word, but im getting the jest of prami.. Many thanks!!!

 

[Rednack]

butch up puss

 

[gearin up]

great info in this thread. Thanks everyone

 

[dav1dg90]

I told ya Heavy knew his shit on Prami LOL!!!! He is a walking encyclopedia LMAO!!! I prefer Caber though over Prami because I get hit hard with flu like symptoms everytime I take Prami for some reason.

 

[jimm]

Does caber posses similar anti depressant effects to prami just wondering as I have caber on way wondering if I should of bought prami?

 

[World-Pharma.org]

Heavy,,,did you ever hear that somebody take 2-3g trenbolone a week?

I talk with some IFBB guy and he say guys take 2-3g trenbolone a week.. i cant imagine if this can be true and how hey can handle it! OMFG!

 

[OldSchoolLifter]

most I have taken per week is 700mg Tren Ace, and 800mg Tren E

 

[World-Pharma.org]

together..wow its really a lot!
me..320mg tren acet. maxx

 

[benchingover500]

I don't get a lot of sides. I do get horny. That's the most significant side. Sometimes I have trouble sleeping, but nothing serious. It may be because I never ran a tren only cycle. Do you take animal pak daily? I do which may help.

 

[heavyiron]

Heavy,,,did you ever hear that somebody take 2-3g trenbolone a week?

I talk with some IFBB guy and he say guys take 2-3g trenbolone a week.. i cant imagine if this can be true and how hey can handle it! OMFG!

The highest I have ever heard of was 1 gram weekly by a reliable source on Tren. This man was stacking the Tren with 1 gram Deca and 1,500mg Test weekly.

 

[OldSchoolLifter]

together..wow its really a lot!
me..320mg tren acet. maxx

No not together, 2 separate runs

 

[FordFan]

The highest I have ever heard of was 1 gram weekly by a reliable source on Tren. This man was stacking the Tren with 1 gram Deca and 1,500mg Test weekly.

This guy had to be a walking milk cow!

 

[piotrekusa1]

I never tried tren but npp fucked me good one time

 

[heavyiron]

This guy had to be a walking milk cow!

He is a mass monster.

 

[UniGlocker]

What anti-depressant do you take? I'm on cymbalta and tren doesn't seem to fuck with that. In my opinion, cymbalta is tits as far as anti-depressants go, so its worth a look anyway. Nevertheless, just dropping tren probably is the smartest/safest thing.

That happens to be the anti-depressant I'm on, and 200mg of TrenE a week kicked Cymbalta + Klonopin's asses; in just 3 doses, or a week and a half. I never could relax...ever! You guys who can handle it, my hat is off to ya'. I can't, and I fought too long and too hard to feel like a normal human being again, thanks to the Cymbalta and Klonopin to wreck it by using Tren when there are plenty of other compounds out there that work just as well.

 

[yerg]

citalopram 60mg
lisionpril 10mg for bp

 

[yerg]

Dose your Prami first thing AM or you will likely have sleep issues. The first time using Prami don't drive. It can really knock you out for a few hours but some guys it really energizes. This effect is dose dependent in studies.

As soon as you get out of bed use .25-0.3mg Prami. Before bed use 0.5mg-1mg Xanax. Stay positive and keep reminding yourself the Tren is the cause of your aggression.

No carbs the last meal of the night or you will be a furnace and sweat a ton.

Good luck brother.

thanks heavy

 

[MDR]

That happens to be the anti-depressant I'm on, and 200mg of TrenE a week kicked Cymbalta + Klonopin's asses; in just 3 doses, or a week and a half. I never could relax...ever! You guys who can handle it, my hat is off to ya'. I can't, and I fought too long and too hard to feel like a normal human being again, thanks to the Cymbalta and Klonopin to wreck it by using Tren when there are plenty of other compounds out there that work just as well.

Tren is not for everyone. Prami or caber helps with the prolactin issues. I think prami is better, but I have some sides with it, so I'm stuck with caber. Works pretty well. If you have existing issues with depression, it can complicate matters. There is no anti-depressant that works for everyone. It pretty much comes down to trying different drugs until you find a good match for you. For some, antidepressant drugs do not work at all.