Since you pin it and its not an oral, I think your liver would not suffer so much. If I were you, I would plan on running 75mg eod, but for more like 8 weeks (you can stop early if you just can't handle the sides). It just gives you a lot more time for it to be effective.
Looking back on my most recent cycle, my best fat loss did seem to come when I ran the highest doses of tren, so it does appear to be nicely thermogenic (but not magic).
You'll just have to try it to see how the side effects are for you. It vary a ton between individuals. I got few bothersome sides from it (progesterone gyno probably the worst). Just know what to expect so that when you get sides you can combat them properly.