copper deficiency

[hardasnails1973]

I had the test done and dr is really looking into insulin dysfunction, but I have an idea test will come back normal like everything else. I found this excerpt but I can not find what causes high glucagon levels other then insulin deficeincy.

In healthy subjects intravenous glucagon administration induces a prompt (at 1 h) fall in serum T3 concentration and a later (at 4 h) rise in biologically inactive rT3. Since high levels of plasma glucagon have frequently been found in some patients with severe chronic illnesses, together with an anomalous thyroid condition (low serum T3, high serum rT3), it has been supposed that hyperglucagonemia could play a pathogenetic role in causing selective T3 deficiency

Serum or urine amino acid levels: These levels demonstrate hypoaminoacidemia. A general decrease of gluconeogenic and nongluconeogenic amino acids occurs, especially alanine and glutamine levels. The cause of the hypoaminoacidemia is thought to be the increased hepatic extraction of amino acids for gluconeogenesis and increased ureagenesis combined with decreased protein synthesis.

REad your link on bile acid congulation and it fits me perfectly except I have low stomach acid I beleive but there is no way to tell this. MY urine test shows beneze pathway is over loaded but I do not eat food preservatives or take steroid injections. But if I remember right taurine or glycine can be used in that detoxfication pathway. Even if I tested normal on cystein levels on urine tests is N- acteyl cysteine the same thing?

Even the supplements we take b-vitamin , C, ect they still require stomach acid to be utlized and absorbed even in powder form or pill form?
Would taking vitamins with apple cider vinegar aid in there absorption if low stomach acids.

So fucked up bile acid production affects your villa as well like celiac?

 

[hardasnails1973]

GOOD INFO !! TROUBLE

Thyoid:
kick start T4-T3 conversion, upregulate thyroid and adrenals

* Increased activity levels to encourage favorable partitioning
* Vinegar (acetate) and citrate (grapefruit, lemon and orange juice)
* Tyrosine, Kelp, Selenium

Hormonal:
Less than stellar hormonal profile - kickstart test production

* Low dose anti-e OR improve estrogen shuttle out of the body via glucuronate
* Forskolin and inositol/glucuronic acic lactone/IP6 (10:2:2), plus selenium methionate plus zinc, ascorbate
*Choline, Nicotinic Acid, Policosanal

Cortisol issues:

* Regular cardio of some type
* Anti-cortisol supp (e.g. 7-OH) at night preferably, daytime cautiously, taurine, omega-3s for control
* Correction of sleep issues: restore GABA, taurine, and phosphoinositol pathways
* Correction of stress issues
* Relaxation supp (e.g. l-theanine), GABA, magnesium

Oxidation issues:

* Vitamin C, Vitamin E, K-R-ALA, Fish Oil

Insulin Regulation:

* Vinegar -Acetate, Chromium, Banaba Leaf, Cinnulin
* Diet - High Protein/Low-Mod Carb for Glucagon/Insulin Regulation

VAT:

* Ab-solved

-Added a few - not positive they are in line with the consensus so feel free to remove any

-I'm definately interested in any more ways to improve endomorphic tendencies, and seeing dosage ranges based upon body mass

 

[Trouble]

Good, now add in the bit about transulfuration pathway, with attention to cysteine and methionine, homocysteine.

Play it again, Sam.

 

[hardasnails1973]

Once I get my cells opened up with proper insulin metabolism then we can start feeding liver/muscle glycogen. Since glucuronic acic lactone acts to increase glyocgen since it is converted from glucose then will adding it in increase glycogen with out insulin present or do you need insulin. I got a pump first time in a while tonight at the gym, but bad shortness of breath on cardio (acidosis - ph in balance)

TRouble whats best type of weight training for glycogenic adaptation?.

should cardio be done away from weights due to it lower glycogen after training (what I am trying to prevent).

And can you shed some light on glucuronic acic lactone on insulin production all I can find cites on damn canines and not humans and if i remeber my phyisology right animals can produce vitamin C endogenously
Thanks actually girl I am dating is going through same thing. CFS and FM How ironic huh? Shes got the works as well candida,altered liver pathways, pain, adrenals,leaky gut , ph imbalances, allergies but being a model you never know it.. First thing I told her is if she wants to get better she has to change lifestyle pattern and stress reduction and calm the hypothalamus adrenal axis. She is working with a naturopath and good MD but all her test ranges are in the range as well but she has low cholesterol, triglycerides, high calcium, It feel like Deja vu LOL... She has epstein bar virus but doesn't 80% of americans as well.

 

[hardasnails1973]

can one be insulin resistant even though they have normal blood work ?

 

[Trouble]

You don't have insulin resistance, you have insulin insufficiency, as indicated by previous blood work.

 

[hardasnails1973]

So basically i am fucked till I get this corrected. Another week till get GTT back and if that comes up normal i am screwed. I ordered everything for insulin protocol hopefully it get here soon. So having low cholesterol and low triglycerides all my life i was prone to this? I love how drs tell you nothing wrong and you are healthy with cholesterol of 100 i had this all my life. I have a gut feeling get insulin working again i can start feeding my glycogen and replenish the liver and muscle pull my body out of this starvation mood and reverse those rt3, as well as reversing acidosis from starvation. i check for ketones and glucose in urine and nothing is showing up. Would this because I am not eating a boatload of carbs like other americans?

 

[Trouble]

*sigh* Do not take the wrong way....

Pull your head out of your ass.

Your insulin is low. Your glucose utilization is as good as it can be with low glucose uptake because of low insulin, which you manage for already to keep you from going too hypo.

You burn your ketones; this is not uncommon for someone in your condition.

The tests will come back showing you have one of 4 types of hypoglycemia, and that will point at insulin insufficiency.

Now look here, you can manage this sucker without a whole lot of wailing and hand wringing, we've talked about what is wrong here, remember?

Regardless of what your docs find, you need :

1. to suck it up and be an adult here - you did more than a little to help yourself down this road, HAN. You can't fool me; you can't blame this on your doctors.

2. You have bad ass stress, and you're stuck in punative thinking. Get positive; you are 99% ahead of the rest of the crowd. Make a vow to manage this condition and slowly get your health back. Its doable and we've talked it out for a dozens and dozens of posts on how to do it, what to do, and when to do it.

3. stop the circular logic that somehow doctor is gonna make it all there there. You are the one who must be proactive. Just as you know damn well this hasn't been a lifelong condition, so you also know that its largely reversible if you get the biochemical knots untangled. You haven't been using the right supps and some of the ones you did use got you into hot water...along with fucking with your thyroid, which had a nasty ass rebound effect.

Get with the progam, get your head clear on square up those shoulders. Do what needs to be done, stop looking for scapegoats.

You're either your own worst enemy or the only problem solver that can made the needed corrections.

 

[P-funk]

I would just love to know how you have enough money to pay for all these tests and all these Doctor's appointments. I can't see insurance covering all this. This has been going for like 3 years with you now, right??

 

[hardasnails1973]

All factors are now being handled as previously discussed. I did run out of BCAAS and i did feel a difference with in a week being off them so reordered some more. My body seems to be processing protein better with BCAAS for some reason. BCAAS are used for liver dysfunction and hepatitus recovery, and stimulate insulin secretion hmmm maybe that is why.

 

[hardasnails1973]

Got my blood sugar from 135 to 85 2 hours after last meal ...YIPPE !! why I feel like I have hardly any anxiety at all. I feel so relaxed and not up tight for a change. feel good actually..

 

[hardasnails1973]

I would just love to know how you have enough money to pay for all these tests and all these Doctor's appointments. I can't see insurance covering all this. This has been going for like 3 years with you now, right??

I fucked my self up from pushing my self to hard physcally and mentally stressed my systems to the max and not being properly supported nutritional along with several other varibles adding fuel to the fire. . As of know what ever the cause does not matter just have to deal with what needs to be done at hand and it is reversible just going to take time. Have to take each layer at a time and slowly rebuild back to normal. Getting blood sugar and mental stress under control are just the first steps to recovery. ALot of the testing is not covered by insurance.

 

[hardasnails1973]

Goal: correct mitochondrion dysfunction, and reduce acid in body, suppress glutamate conversion from glutamine

I just recieved my k rala, acetlycarnitine, co enzyme q10, bentifomine (b-1), d biotin, coenyzme b complex, carosine. ACtually found real citric acid (tastes like shit).

I was researching and was figuring for mitochondrial dysfunction
100 mgs k rala with 3-4 meals
1000 mgs ALCAR 2 times a day,
300 mgs (b-1) 2 times a day
200 mgs co enyzme q10 x 2 times
10 mgs d biotin once a day
1000 mgs carosine x 2 times
subligual co enzyme b 2 x 2 a day

can not find literature on if the r-isomer will chelate minerals out of the body (zinc, copper, manganese).

Lab should be in for intracellular testing of minerals, vitamins, antioxidents (ALA,nac,gluthione,sulfur) so from there I can supplement only what is required and stop wasting money playing guessing games...

Adding in supergreen foods for alkalizing body as well as reverse osomosis water 32 oz once a day mixed in
diet is 80% alklaine, 20% acid (using protein shakes as previously indicated)
potassium is at 5 grams and sodium is a 2-3 grams (celtic sea salts)
2 hours of sunight a day if possible
Stress reduction - mediation 20 minutes x2 times a day
all computers , tV shut off 1 hour before bed , read a book to relax mind
1 hour before bed 500 mgs calcium hyproxilaite with 500 mgs before bed (sleep like a baby and do not wake up till 6 am with energy), Breathing is much better sleeping after taking cal/mag combo
3 healty trinity before bed time for probiotics.

Still have samme going at 800 mgs a day with 2000 mgs TMG, 1000 mgs inosital/choline, 500 mgs gaba , taurine, x3 , magnesium, 5000 mgs glutemine, 5000 mgs BCAAS, 200 mgs theanine x3

Energy levels are increasing, mind feels more calming not so much anxiety, still feeling dehyrated even from drinking water with sea salt

 

[Trouble]

Do not use glutamine. Its toxic to you. Its causing your dehyration. Pitch it out or mark it as toxic. I can't believe that you're contemplating using it. You have a nitrogen cycle issue in liver and brain. You buildup ammonia and have insufficient NAC, methionine and cyseine to make glutathione (and that takes B6 which you don't absorb and convert correctly). I would use small doses of sea salt and also V-8 juice to get meet your sodium needs. Where is your sam-e? You need it and PUFA-3, vitamin E, vitamin C, and alcar as anti-oxidants.

Be very careful loading up with potassium and calcium and not balancing it with sufficient magnesium. Its magnesium, not calcium, that you short of.

You need zinc, and you need the active form of B6, P5P to add to your stack. Its one of the key cofactors that you can't absorb or make in your present state. If should be taken with vitamin B12 and B2 (usually comes prepared with B2).

 

[hardasnails1973]

Zinc is at 60 mgs a day with 4 mgs copper
sam-e is at 400 mgs x 2 times a day, 20 minutes before meals before 3 pm
P5P is in the coemzyme subligual b vitamins 50 mgs
Glutamine is DROPPED as of now. Yes My ammonia was higher then any other metabolic factor on organic acids test,
magnesium 1/1 ratio with calcium (500 mgs supplemental) 1000 mgs each
vitamin C ascorbate 3000 mgs a day
vitamin e 800 ius
glutamine is converting to glutamate as previously discussed, i thought gabba neutalizes this reaction? Glutamine is suppose to in crease cell hyrdation but in my case it is ausing cellular dehyration correct

Omega 3's are provided in balaced EFA formula added to shakes. RBC lipid showed elevated dha, epa levels (probably not getting transported in to mitochondrion for metabolism) with low levels of LA, LNA

400 mgs b-2 once a day piss is still not yellow. Does this mean I need more?

Could this explain my conversion problem?
This glutamate-glutamine conversion also requires ATP energy, however, and this anti-excitotoxic mechanism is also at risk if cellular energy production is comprises for any reason. (3) Also, excessive free radicals can prevent glutamate uptake by astrocytes, thereby significantly (and dangerously) raising extra cellular glutamate levels (18). (18).

From this brief discussion of the mechanisms of NMDA-glutamate excitotoxicity, it should be clear that there are 5 main conditions which allow glutamate to shift from neurotransmitter to excitotoxin:

1) inadequate neuronal ATP levels (whatever the cause);

2) inadequate neuronal levels of magnesium, the natural, non-drug calcium channel blocker;

3) high inflammatory prostaglandin / leukotriene levels (caused by excessive glutamate-NMDA stimulated calcium invasion);

4) excessive free radical formation (caused by prostaglandin / leukotriene formation and/or insufficient intracellular antioxidants/free radical scavengers;

5) inadequate removal of glutamate from the extracellular (synaptic) space back into neurons or into astrocytes.




Trouble I have been taking P5P for a long time but for some reason it is not getting uptake into the cell. Is this because of inuslin imbalance? or other factors such as ph level? With out conversion of glutamine from glutamate would it make it difficult to neutralize the acid and balance ph?. This deficiency would explain my slight seizures i have been having. Probing further the GAD enzyme needs zinc as well and all the DAMN reports I get tell me i am low in zinc despite taking it. This low zinc would also explain why some enzyme with p5p are working and ones a filated with zinc are not..

trouble am I getting warmer about learning what is going on with NMDA?
Thanks

 

[hardasnails1973]

So if i was eating all those whole eggs and poly unsat fats as on that "detox" diet and I was already low on carnitine (via urine testing) to begin with. What would reprocussions be? a more compromised fatty liver?

Since i was taking cocconut oil in the past and had built up saturated fats in cell membrane. I understand that MCT do not need carnitine to be transported in the mitochondrion, but does carnitine need to be present for them to be utlizied for cellular energy?

If your body is low in choline will it break down cell membranes to replenish it and induced apoptoisis?

How much scientific truth is to the fact that if your ph is altered nutrients would have harder time entering the cell for processing?

 

[hardasnails1973]

TRouble how does ALA chelate minerals (copper,ect)
Does it do it by pulling it out of cell/tissue or by binding it up in the intestinal tract
Does R-ALA pose the same threat as metal chelator

Will zinc loznegers alleviate any problems with digestive tract?

 

[hardasnails1973]

Trouble does lack of bile flow when eating fats cause "soap" to form in the intestines and can hinder aborption of other minerals?

 

[hardasnails1973]

Just got my tests back from mineral analysis
Co enzyme q10 is severely deficeiny
zinc as well
and vitamin E is in the shitter

Problem in mitochondrion is oxidative phosphorylation which is inhibiting ATP

 

[hardasnails1973]

Sensitivity to gabba has completely gone and sleep is back to sound 8 hours. Breathing is much deeper and relaxed, not as shallow during sleep. Bowels are moving better they have in a year. Energy is back to normal no need for sleep any more.

i am just curious of how computer can affect serotonin levels. Since light stimulates serotonoin i would figure it would raise it? is the problem with computers the duration which one sits in front of them or more so the time that is spent later at night is more the problem or combination of the both

Which would cause lower serotonin , melatonin levels

a person that is in office all day long in front of computer and does not go on at all after dark
or
a person that is not infront of the computer all day long and decides to go on 2-3 hours when it is dark

People think i am nuts for having a shield in radition shield on my computer and also one one my cell phone..

 

[Trouble]

Its not a function of magnetic effects.

Its related to brain stimulation duration and intensity.

 

[hardasnails1973]

up at 6 am
relaxation for 20 minutes

meal 1
lean protein - 3oz beef/turkey combination
yams - 4oz
veggies steams - 2 cups
organic butter on yam -

30 minute walk after breakfast outside

meal 2,3,4
whey/egg protein mix 30 grams
1 raw organic egg - eggglands
1/3 cup barely bran
2 tsp udos 1 tsp EVO

meal 5
lean protein
spinach
1/2 cup presaoked legummes

20-30 minute walk after dinner outside

bed by 10 pm or bed relaxation 20 minutes

Sunlight 1-2 hours a day
Samme 400 BID
coenzyme q 10 200 mgs TID
esterC - 500 mgs each meal
vitamin E 800 ius BID
multivitamin/mineral before breakfast/dinner
super digestive enzyme - 1 each meal
gabba/taurine/magnesium/theanine - 500/500/200/200 TID
PC - 800 mgs TID with meals
RALA/ALC - 100 mgs/500 mgs BID
Apple cider - 2 TBSP TID
methlyl cobalain 5000 mcgs BID
folonic acid 800 mgs BID
zinc lozengers 30 mgs BID
b coenyzme subligual TID
TMG 1000 mgs BID
probiotic 50 bilion before bed Bifidolpholic - natren trinity
calcium 250 mgs TID
iron chelated 25 mgs BID

 

[hardasnails1973]

Update
Through troubles advice I am getting back on my feet back to benching 315 for a few and squating 405 for a few but its a start. Constipation is still a bitch but thats due to adrenal/ thyroid /liver imbalance. i am going to dr and see if i can get time released t-3 because when ever I take armour thyroid I crap 2 hour on the dot probably be cause t-3 peaks during that time, but its only my guess. The herb gynemna sylverstra has help trendously balancing out my blood sugar levels as well as reducing adrenaline associates with reactive hypoglycemia which alot of people have and do not even know it. Hope this helps some other people. But never giving up my relaxation 2 times a day or my walks. I am also flushing out liver/ gallbladder with PC to help heal the cell membranes and to prevent EFA deficeincy due to cell membrane deterioration. As trouble mentioned before if i can replenish the glycogen levels in my liver that will definetly add in recovery of thyroid due to prolong starvation mood. I am estimating a good 4-6 months to accomplish that.

 

[Trouble]

meal 1
lean protein - 3oz beef/turkey combination
yams - 4oz
veggies steamed or raw - 2 cups
organic butter on yam -

30 minute walk after breakfast outside. Belly breathing, meditative walk.

meal 2,3,4
whey/egg protein mix 30 grams plus small amount unflavored yogurt
1 raw organic egg - eggglands / or 4 or 5 egg whites
1/3 cup barely, rice or oat bran
raw vegetable, 1/2 cup serving, munch after shake
1 tsp EVO

meal 5
8-10 oz lean protein
spinach salad
1/2 cup presaoked legummes

Want you to look into chia seeds, soaked, to add to shakes as well.

20-30 minute walk after dinner outside

bed by 10 pm or bed relaxation 20 minutes

Sunlight 30-60 min a day, before 10am, after 4pm
Samme 600 BID
coenzyme q 10 200 mgs TID
esterC - 500 mgs each meal, 2-4 grams per day
vitamin E 800 ius BID plus selenium methionate
multivitamin/mineral before breakfast/dinner
super digestive enzyme - 1 each meal
gabba/taurine/magnesium/theanine - 500/500/200/200 (at night) TID
PC - 800 mgs TID with meals or use inositol plus choline, 500mgs each, 2x

Apple cider - would rather see you using citrate plus B5
methlyl cobalamin 5000 mcgs BID
folic acid 800 mgs BID
zinc lozengers 30 mgs BID
b coenyzme subligual TID ..if this P5P??
TMG 1000 mgs BID x 2
probiotic 50 bilion before bed Bifidolpholic - natren trinity
calcium 250 mgs TID
iron chelated 25 mgs BID (skip one out of 4 weeks to avoid toxicity)

 

[hardasnails1973]

I will add those changes
b-5 500 mgs breakfast and dinner (forgot that)
b-6 p5p subligual 50 mgs BID -could too much of this cause homocysteine to divert to CBS vs methione pathway?

What are some things that cause homocysteine to divert to CBS vs methione pathway?

Where do I get citrate? I use magnesium citrate is that the same. I know what you mean to increase kreb cycle intermediates by increasing Coenzyme A. Does the apple cider provide the acetyl group for TCA cycle? i am also using ALCAR at 500mgs tid and it is really helping with memorr.

Will the samme and TMG help to increase serotonin turnover AKA raise 5hiaa on urine test since mine does not even measure that is what my main problem is serotonin metabolism is like non existent.

So how much TMG 1000 mgs 4 times a day or 2000 mgs x 2 ?

Selenium in multivitamine

why sunlight before 10 and 4 pm ? i thought you want it to be at strongest around 12-3, but person with weak adrenals might not be good idea huh?

 

[Trouble]

>b-5 500 mgs breakfast and dinner (forgot that)

Okay. Some folks don't convert the commercial form of B6 to the active form of P5P.


>What are some things that cause homocysteine to divert to CBS vs methione pathway?

Too much sulfate or sulfide (esp of you have a sufite oxidase deficiency)
Not enough molybdenum.
Selenium is an enzyme active site center metal in some of the steps in the methylation and transulfuration pathways.
> I use magnesium citrate is that the same. I know what you mean to increase kreb cycle intermediates by increasing Coenzyme A.

Then you don't need it.

Does the apple cider provide the acetyl group for TCA cycle?

Not so much as it provides acetate for production of glutamate. I wonder...would you be willing to try AKG? It sucks up excess ammonia..what did your metamatrix test show wrt ammonia?

> i am also using ALCAR at 500mgs tid and it is really helping with memorr.

Yeah, thats carnitine and acetyl transfer, used in many reactions. Acetyl function enhances transport and uptake of carnitine into mito.

>Will the samme and TMG help to increase serotonin turnover AKA raise 5hiaa on urine test since mine does not even measure that is what my main problem is serotonin metabolism is like non existent.

Yes sir. But more importantly, it also provides methylation support in liver. Its also acts as an important liver nuclear receptor conditioner for gut.

So how much TMG 1000 mgs 4 times a day or 2000 mgs x 2 ?

1g twice per day, just before meals.

>Selenium in multivitamine

Yes, but how much? 20-60mcg isn't enough, you have a shortage. Try adding a 200 mcg dose just a couple times per week. That will keep it from building up to excess, but boost your levels.

I am unsure of you using Fe. Its where the iron is, not that you don't have any...ferritin is the problem (iron transport). Thats sulfate driven, and thats yet another reason to goose up the transulfuration pathway.

>why sunlight before 10 and 4 pm ? i thought you want it to be at strongest around 12-3, but person with weak adrenals might not be good idea

Its called cancer risk reduction. Sunlight is good, prudent use of it is even better.

You don't need hours, just 20 min min, 45 min is better, every day or so.

Daily sunlight regulates carbohydrate metabolism and helps reset melatonin and vitamin D3 synthesis. That directly influences dopamine and serotonin.

Make sense?

 

[hardasnails1973]

Yes i am following you completely understanding every thing what you are telling and have taught me plain as english and have been for past 6-8 months

i am really begining to understand methylation and how if you are low you are basically screwed and possible headed for cancer and mutated DNA, other not so pleasant things..

As soon as i spoted sufite oxidase deficiency i knew molydenum was next to follow.

metametrix should normal ammonia mid range but that was one of the only reading in the mid normal range why i have been keeping protein levels low just in case. AkG if i am not mistaken is a good way to increase glutamine levels with out taking glutamine. And it was recommended on my metametrix test due to low citrate levels. But only i had a hard time finding just akg by itself because it is usually attached to some thing else.

Been doing alot of reseach and found alot of people that are undermethylated have underactive thyroids. is this just coincidence or is there something more i need to dig deeper about to justify. I found a few study linked to hypomethylation but nothing supported by nothing concrete.
One thing i found and also you pointed out in another post was about how underactive thyroid alters b-2 metabolism and causes increase in CBS pathway.

So indirectly hypothyroidism could possible deactivate the methione synthase by actually lower the Igf-1 that drives it?

Which could make alot of sense since my b-2 levels are low despite taking good amount of b-2 intake and my hypothesis is that zinc falls into this same category as well, just have not been able to prove it YET
I love to find that article about how zinc serum levels are altered in hypothyroidism and not untill the thyroid is optimal will they begin to normalize

molydenium i am at 150 mcgs a day from multivitamin that should cover basis I hope


taking 200 mgs selenium methioine from multi vitamin so i got that covered .
Since being vitamin E deficienct could this have an affect on metabolism of the selenium even though i have plenty of it in my cells?

 

[Trouble]

Custom Nutrition Warehouse.

100 g, 6 bucks.

Pubmed Search: Alpha ketoglutaric acid and excitotoxicty.

(ignore this wernickes syndrome, we're interested in the AKG shunt fuckup that causes ammonia build up and with it, build up glutmate and lack of glutathione and GABA.

(see what happens when you feed it to gut: instant rebuilding of depleted GABA stores in gut mucosal cells: http://www.ncbi.nlm.nih.gov/entrez/...=Retrieve&dopt=AbstractPlus&list_uids=7609280)


BINGO! AGK is an ammonia absorber--> reduces localized excitotoxicity in brain, liver, pancreas and gut from excess NMDA and glutamate buildup from nitrogen cycling issues in liver.

Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy.

Desjardins P, Butterworth RF. Mol Neurobiol. 2005;31(1-3):17-25.

Thiamine deficiency results in Wernicke's encephalopathy and is commonly encountered in chronic alcoholism, gastrointestinal diseases, and HIV AIDS. The earliest metabolic consequence of thiamine deficiency is a selective loss in activity of the thiamine diphosphate-dependent enzyme alpha-ketoglutarate dehydrogenase (alpha-KGDH), a rate-limiting tricarboxylic acid cycle enzyme. Thiamine deficiency is characterized neuropathologically by selective neuronal cell death in the thalamus, pons, and cerebellum. The cause of this region-selective neuronal loss is unknown, but mechanisms involving cellular energy failure, focal lactic acidosis, and NMDA receptor-mediated excitotoxicity have classically been implicated. More recently, evidence supports a role for oxidative stress. Evidence includes increased endothelial nitric oxide synthase, nitrotyrosine deposition, microglial activation, and lipid peroxidation. Reactive oxygen species production results in decreased expression of astrocytic glutamate transporters and decreased activities of alpha-KGDH, resulting in an amplification of cell death mechanisms in thiamine deficiency.

Oh, that answers your question on B2.

On zinc, its another enzyme active site metal.

GABA directly signals for hGH and IGF-1.

Answer on Se and vit E: yes, but only if Se is being removed ...or its being tied up by excess Hg and Pb ( mercury and lead).

Hypothyroidism: thyroid receptor gene regulators are selenium, gluthathione, zinc and methionine. Hypomethylation results in a downregulation of thyroid receptor. Excess bile and low cholesterol results in lack of adequate thyroid hormone AND reduced T4--> T3 activity

But its that blockade of TCA that really screws with energy metabolism for maintaining body temperature.

See how it fits together rather neatly? (at least it sounds good, LOL)

 

[Trouble]

Taruine and magnesium shortages are implicated in reactive hypoglycemia.

AKG and insulin release in pancreatic islet beta cells.

http://www.ncbi.nlm.nih.gov/entrez/...Retrieve&dopt=AbstractPlus&list_uids=12575909

 

[hardasnails1973]

Bingo!!
Hypothyroidism: thyroid receptor gene regulators are selenium, gluthathione, zinc and methionine. Hypomethylation results in a downregulation of thyroid receptor. Excess bile and low cholesterol results in lack of adequate thyroid hormone AND reduced T4--> T3 activity

No fucken wonder thyroid is not fucken working I only have half of the receptors available, but working on correcting that

That statement above just describe me to the T. Light bulb went on !! I am now starting to see that when I have low levels of cholesterol, ldl, on my blood work its not because they are low but rather they are being stored by the liver and are building up instead of being released. And I bet if I have a bile acids test ran it probably would be low normal as well indicating the same. Choline I am low on that has been verified by several tests directly and indirectly and this would definetly affect liver folate levels as well plus methylation.


So the AKG will help regulate insulin secretions which i could definitely use.

Could having lower then normal insulin levels also raise a persons adrenaline levels which is commonly seen on a typical bodybuilding diet? Now if we couple that with caffine, ephederine plus over training, stress ful lifestyle then we are one a way path for self destruction.


I do not have taurine deficency actually have an excess because of homocystein being diverted to CBS pathway signaling undermethylation.
Mercury is definetly been rule out and I have not had tuna in ages. Urine test with DMPS showed little elevation nothing drastic, same way with hair analyisis.

Personally what fuck me up was my life style that ran on pure adrenaline fueled by caffine and ephederine low carb dieting and no cardio, high demanding job that involved extreme multitasking, plus an aggressive girlfreind at the time did not help. And eventually i created an imbalance between excitory and inhiboratory neurotransmitters. Excessive dopamine , adrenaline, glutamate and literally depleted my serotonin/gaba/acetylcholine levels where it started to affect the liver/thyroid/gut imbalance.

Yes it does fit in nicely
i am starting to see how your main emphasis is shutting down the excitory neurotransmitters and replenishing the inhibitory ones through lifestyle changes (mediation, walks, sunlight,balanced eating, supplementation) as well as addressing the brain/ liver/gut imbalances and improving regulating methylation/transulfation/cbs pathways which doing so brings the body back to balance as a whole rather then just treating one thing at a time like the traditional dr will do. Its absolutely brillant concept much like the traditional chinese medicine which treats the entire body rather then one area. When i look at what you have emphasis you do run along the same meridians as much of the chinese medicine.